C-terminal binding protein 2 is a novel tumor suppressor targeting the MYC-IRF4 axis in multiple myeloma.

Autor: Cheung CHY; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Cheng CK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Leung KT; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China., Zhang C; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China., Ho CY; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Luo X; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Kam AYF; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Xia T; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Wan TSK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Pitts HA; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan NPH; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Cheung JS; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Wong RSM; Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China., Zhang XB; Department of Medicine, Loma Linda University, Loma Linda, California., Ng MHL; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.

Publikováno v: Blood advances [Blood Adv] 2024 May 14; Vol. 8 (9), pp. 2217-2234.

SPINK2 Protein Expression Is an Independent Adverse Prognostic Marker in AML and Is Potentially Implicated in the Regulation of Ferroptosis and Immune Response.

Autor: Pitts HA; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Cheng CK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Cheung JS; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Sun MK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Yung YL; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan HY; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Wong RSM; Sir Y.K. Pao Centre for Cancer, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Yip SF; Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong SAR, China., Lau KN; Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong SAR, China., Wong WS; Pathology Department, Queen Elizabeth Hospital, Hong Kong SAR, China., Raghupathy R; Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan NPH; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China., Ng MHL; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.; State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong SAR, China.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.

Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine.

Autor: Wang H; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Chan KYY; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Cheng CK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong., Ng MHL; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong., Lee PY; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Cheng FWT; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Kowloon, Hong Kong., Lam GKS; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Kowloon, Hong Kong., Chow TW; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Kowloon, Hong Kong., Ha SY; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Chiang AKS; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Leung WH; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Leung AYH; Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Wang CC; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong., Zhang T; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong., Zhang XB; Department of Medicine, Loma Linda University, Loma Linda, California., So CC; Department of Pathology, Hong Kong Children's Hospital, Kowloon, Hong Kong., Yuen YP; Department of Pathology, Hong Kong Children's Hospital, Kowloon, Hong Kong., Sun Q; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Zhang C; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Xu Y; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Cheung JTK; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Ng WH; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Tang PM; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong., Kang W; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong., To KF; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong., Lee WYW; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong., Wong RSM; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong., Poon ENY; School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong., Zhao Q; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau., Huang J; Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China., Chen C; Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China., Yuen PMP; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Li CK; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong., Leung AWK; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong., Leung KT; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong.

Publikováno v: Blood cancer discovery [Blood Cancer Discov] 2022 Nov 02; Vol. 3 (6), pp. 516-535.

A novel NUP98-JADE2 fusion in a patient with acute myeloid leukemia resembling acute promyelocytic leukemia.

Autor: Cheng CK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and., Chan HY; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and., Yung YL; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and., Wan TSK; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and., Leung AWK; Department of Pediatrics and., Li CK; Department of Pediatrics and., Tian K; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and., Chan NPH; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and., Cheung JS; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and., Ng MHL; Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; and.; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.

Publikováno v: Blood advances [Blood Adv] 2022 Jan 25; Vol. 6 (2), pp. 410-415.

R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling.

Autor: Chan KYY; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Zhang C; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Wong YTS; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Zhang XB; Department of Medicine, Loma Linda University, Loma Linda, CA., Wang CC; Department of Obstetrics and Gynaecology., Ng WH; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Fok SP; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Tang PMK; Department of Anatomical and Cellular Pathology., Kang W; Department of Anatomical and Cellular Pathology., Feng B; School of Biomedical Sciences., Poon ENY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong., Lee KY; Hong Kong Red Cross Blood Transfusion Service, Yau Ma Tei, Hong Kong., Lee CK; Hong Kong Red Cross Blood Transfusion Service, Yau Ma Tei, Hong Kong., Chen C; Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China; and., Leung TY; Department of Obstetrics and Gynaecology., Ng MHL; Department of Anatomical and Cellular Pathology., To KF; Department of Anatomical and Cellular Pathology., Wang H; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Lam HS; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Ng PC; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Yuen PMP; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Li K; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Leung AWK; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong., Li CK; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong., Leung KT; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong.

Publikováno v: Blood advances [Blood Adv] 2021 Nov 09; Vol. 5 (21), pp. 4380-4392.