Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Autor: Hong S; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Beja-Glasser VF; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Nfonoyim BM; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Frouin A; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Li S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Ramakrishnan S; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Merry KM; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Shi Q; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Rosenthal A; Alector Inc., 953 Indiana St, San Francisco, California 94107, USA.; Annexon Biosciences, 280 Utah Avenue Suite 110, South San Francisco, California 94080, USA.; Department of Anatomy, University of California San Francisco, California 94143, USA., Barres BA; Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA., Lemere CA; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Selkoe DJ; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Prothena Biosciences, Dublin, Ireland., Stevens B; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2016 May 06; Vol. 352 (6286), pp. 712-716. Date of Electronic Publication: 2016 Mar 31.