Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Nfkb activation"'
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Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation
Autor: Sena Lee, Mi Jeong Kim, Eunyoung Chun, Ki-Young Lee, Yoon Min
TRAF6 (TNF receptor associated factor 6) plays a pivotal role in NFKB activation and macroautphagy/autophagy activation induced by TLR4 (toll like receptor 4) signaling. The objective of this study was to determine the functional role of PRDX1 (perox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a770e32748778848a5044965913d922
https://europepmc.org/articles/PMC6208450/
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8
Missing C-terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis
Autor: W.H. Irwin McLean, Maja M. Suter, Eliane J. Müller, Arnaud Galichet, Ludovic Chervet, Huijia Chen, Petra Roosje
Publikováno v: Experimental Dermatology. 19:e343-e346
Filaggrin loss-of-function mutations resulting in C-terminal protein truncations are strong predisposing factors in human atopic dermatitis (AD). To assess the possibility of similar truncations in canine AD, an exclusion strategy was designed on 16
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24de4b77ec3b149e5900ac2a4dc55015
https://doi.org/10.1111/j.1600-0625.2010.01109.x
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9
Aberration in NFkB–IkB Binding May Cause Two States of NFkB Activity
Autor: Raghvendra Singh
Publikováno v: Current Science. 113:2168
NFkB activation is involved in cell survival and aberration of NFkB signalling is found in cancer. IkB is an inhibitor that sequesters NFkB in the cytoplasm. By mathematical modelling, we predict that under an aberrant condition in which IkB does not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f5c02bde1672a403b9498ae99e62a94
https://doi.org/10.18520/cs/v113/i11/2168-2174
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10
Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A3 adenosine receptors in human renal cells: Implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells
Autor: Fabrizio Vincenzi, Gianluca Aguiari, Chiara Durante, Rosario Rizzuto, Laura del Senno, Alessandra Mangolini, Luigi Catizone, Stefania Gessi, Katia Varani, Marco Bogo, Valeria Sacchetto, Peter C. Harris, Pier Andrea Borea
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1792(6):531-540
Cyst growth and expansion in autosomal dominant polycystic kidney disease (ADPKD) has been attributed to numerous factors, including ATP, cAMP and adenosine signalling. Although the role of ATP and cAMP has been widely investigated in PKD1-deficient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdffe1e1fe0f45917fa650b4a691009
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Plný text Recenzováno Digitální knihovna AV ČR
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