Hypoglycemic Activity of a Series of α-Alkylthio and α-Alkoxy Carboxylic Acids Related to Ciglitazone

Autor: David Alan Clark, P. E. Genereux, E. M. Gibbs, Newton Ls, D. M. Lewis, Bernard Hulin

Publikováno v: Journal of Medicinal Chemistry. 39:3897-3907

The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecul

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https://doi.org/10.1021/jm960230h

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Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration.

Autor: Pingitore V; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.; Department of Biological and Health Sciences, Universidad Loyola Andalucía, Dos Hermanas, Seville 41704, Spain., Pancholi J; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Hornsby TW; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Warne J; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Pryce G; Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AT, UK., McCormick LJ; EPSRC National Crystallography Service, School of Chemistry, University of Southampton, Highfield Southampton SO17 1BJ, UK., Hill J; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK., Bhosale G; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK., Peng J; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Newton LS; Division of Infection and Immunity, University College London, London WC1E 6BT, UK., Towers GJ; Division of Infection and Immunity, University College London, London WC1E 6BT, UK., Coles SJ; EPSRC National Crystallography Service, School of Chemistry, University of Southampton, Highfield Southampton SO17 1BJ, UK., Chan AWE; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Duchen MR; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK., Szabadkai G; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK.; Department of Biomedical Sciences, University of Padua, Padua 35131 Italy., Baker D; Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AT, UK., Selwood DL; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.

Publikováno v: Science advances [Sci Adv] 2024 Jul 12; Vol. 10 (28), pp. eado3501. Date of Electronic Publication: 2024 Jul 10.

2-Mercaptoacetamidine and derivatives as antiradiation agents.

Autor: Westland RD, Merz MM, Alexander SM, Newton LS, Bauer L, Conway TT, Barton JM, Khullar KK, Devdhar PB, Grenan MM

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1972 Dec; Vol. 15 (12), pp. 1313-21.