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Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS

Autor: Newman, Carla F., Havelund, Rasmus, Passarelli, Melissa K., Marshall, Peter S., Francis, Ian, West, Andy, Alexander, Morgan R., Gilmore, Ian S., Dollery, Colin T.

ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method extends to three other cell lines relevant to drug discovery: human embryonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b795977492b0f54eaa23703587a4c3cb
https://nottingham-repository.worktribe.com/file/893746/1/091017_Manuscript.pdf

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Intracellular Drug Uptake-A Comparison of Single Cell Measurements Using ToF-SIMS Imaging and Quantification from Cell Populations with LC/MS/MS.

Autor: Newman CF; GlaxoSmithKline , Stevenage SG1 2NY, United Kingdom.; Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom., Havelund R; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory (NPL) , Teddington, Middlesex TW11 0LW, United Kingdom., Passarelli MK; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory (NPL) , Teddington, Middlesex TW11 0LW, United Kingdom., Marshall PS; GlaxoSmithKline , Stevenage SG1 2NY, United Kingdom., Francis I; GlaxoSmithKline , Stevenage SG1 2NY, United Kingdom., West A; GlaxoSmithKline , Stevenage SG1 2NY, United Kingdom., Alexander MR; Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom., Gilmore IS; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory (NPL) , Teddington, Middlesex TW11 0LW, United Kingdom., Dollery CT; GlaxoSmithKline , Stevenage SG1 2NY, United Kingdom.

Publikováno v: Analytical chemistry [Anal Chem] 2017 Nov 21; Vol. 89 (22), pp. 11944-11953. Date of Electronic Publication: 2017 Nov 08.