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Molecular Changes in Neurons in Multiple Sclerosis: Altered Axonal Expression of Na v 1.2 and Na v 1.6 Sodium Channels and Na + / Ca 2+ Exchanger

Autor: Craner, Matthew J., Newcombe, Jia, Black, Joel A., Hartle, Caroline, Cuzner, M. Louise, Waxman, Stephen G.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2004 May . 101(21), 8168-8173.

Externí odkaz: https://www.jstor.org/stable/3372469

CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination

Autor: Holley, Janet E., Bremer, Edwin, Kendall, Alexandra C., de Bruyn, Marco, Helfrich, Wijnand, Tarr, Joanna M., Newcombe, Jia, Gutowski, Nicholas J., Eggleton, Paul

Publikováno v: In Multiple Sclerosis and Related Disorders September 2014 3(5):650-658

STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases.

Autor: Ferecskó, Alex S., Smallwood, Miranda J., Moore, Adrian, Liddle, Corin, Newcombe, Jia, Holley, Janet, Whatmore, Jacqueline, Gutowski, Nicholas J., Eggleton, Paul

Publikováno v: Biomedicines; May2023, Vol. 11 Issue 5, p1375, 21p

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Autor: Brown, Anna-Leigh, Wilkins, Oscar G., Keuss, Matthew J., Hill, Sarah E., Zanovello, Matteo, Lee, Weaverly Colleen, Bampton, Alexander, Lee, Flora C. Y., Masino, Laura, Qi, Yue A., Bryce-Smith, Sam, Gatt, Ariana, Hallegger, Martina, Fagegaltier, Delphine, Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos. A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matthew, Aronica, Eleonora, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H., Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Lerner, Yossef, Sattler, Rita, Van Keuren-Jensen, Kendall, Rozenblatt-Rosen, Orit, Lindblad-Toh, Kerstin, Nicholson, Katharine, Gregersen, Peter, Lee, Jeong-Ho, Kokos, Sulev, Muljo, Stephen, Newcombe, Jia, Gustavsson, Emil K., Seddighi, Sahba, Reyes, Joel F., Coon, Steven L., Ramos, Daniel, Schiavo, Giampietro, Fisher, Elizabeth M. C., Secrier, Maria, Lashley, Tammaryn, Ule, Jernej, Buratti, Emanuele, Humphrey, Jack, Ward, Michael E.

Publikováno v: Nature, 603(7899), 131-137. Nature Publishing Group
Nature, vol 603, iss 7899
NYGC ALS Consortium 2022, ' TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A ', Nature, vol. 603, no. 7899, pp. 131-137 . https://doi.org/10.1038/s41586-022-04436-3
Nature, 603(7899), 131-+. NATURE PORTFOLIO

Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic lateral sclerosis and frontotemporal dementia1–3, two related neurodegenerative diseases defined by mislocalization of the RNA-binding protein TDP-434,5. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a25848cce9d1ba10e3d3a48fd3e242