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Akademický článek

Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

Autor: Arun MZ, Reel B, Sala-Newby GB, Bond M, Tsaousi A, Maskell P, Newby AC

Publikováno v: Drug Design, Development and Therapy, Vol 2016, Iss Issue 1, Pp 1453-1460 (2016)

Mehmet Zuhuri Arun,1 Buket Reel,1 Graciela B Sala-Newby,2 Mark Bond,2 Aikaterini Tsaousi,2 Perry Maskell,2 Andrew C Newby21Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey; 2Bristol Heart Institute, University of Bristol

Externí odkaz: https://doaj.org/article/d1643b699f274f85af385dd1f170ed7e

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Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

Autor: Smith, SA, Sessions, RB, Shoemark, DK, Williams, C, Ebrahimighaei, R, McNeill, MC, Crump, MP, McKay, TR, Harris, G, Newby, AC, Bond, M

Publikováno v: Smith, S A, Sessions, R B, Shoemark, D K, Williams, C, Ebrahimighaei, R, McNeill, M C, Crump, M P, McKay, T R, Harris, G, Newby, A C & Bond, M 2019, ' Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking ', Journal of Medicinal Chemistry, vol. 62, no. 3, pp. 1291-1305 . https://doi.org/10.1021/acs.jmedchem.8b01402

© Copyright 2019 American Chemical Society. The Hippo pathway is an important regulator of cell growth, proliferation, and migration. TEAD transcription factors, which lie at the core of the Hippo pathway, are essential for regulation of organ growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bd2c1769f941be67765bcabacea0e117
https://research-information.bris.ac.uk/ws/files/185252962/acs.jmedchem.8b01402.pdf

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MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin

Autor: Di Gregoli, K, Mohamad Anuar, NN, Bianco, R, White, SJ, Newby, AC, George, SJ, Johnson, JL

Publikováno v: Di Gregoli, K, Mohamad Anuar, N N, Bianco, R, White, S J, Newby, A C, George, S J & Johnson, J L 2017, ' MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin ', Circulation Research, vol. 120, no. 1, pp. 49-65 . https://doi.org/10.1161/CIRCRESAHA.116.309321

Rationale: Atherosclerosis and aneurysms are leading causes of mortality worldwide. MicroRNAs (miRs) are key determinants of gene and protein expression, and atypical miR expression has been associated with many cardiovascular diseases; although thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::af4411c4791e3f8dc281f04cdaface09
https://research-information.bris.ac.uk/ws/files/100454893/49.full.pdf

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Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells

Autor: Teasdale, JE, Hazell, GGJ, Peachey, AMG, Sala-Newby, GB, Hindmarch, CCT, McKay, T, Bond, M, Newby, AC, White, SJ

Publikováno v: Teasdale, J E, Hazell, G G J, Peachey, A M G, Sala-Newby, G B, Hindmarch, C C T, McKay, T R, Bond, M, Newby, A C & White, S J 2017, ' Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells ', Scientific Reports, vol. 7, 39945 . https://doi.org/10.1038/srep39945

Endothelial dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants derived from cigarette smoke is known to promote coronary atherosclerosis and increase the likelihood of myocardial infarctions and strokes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fb80990e69abc9bfbcb703dcbec4d41a
https://research-information.bris.ac.uk/en/publications/a0e81246-0381-4d52-984b-8a907961bd1b

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PI16 is a shear stress and inflammation-regulated inhibitor of MMP2

Autor: White, SJ, Hazzell, GG, Peachey, AM, Teasdale, JE, Sala-Newby, G, Angelini, G, Newby, AC

Publikováno v: Hazell, G G J, Peachey, A M G, Teasdale, J E, Sala-Newby, G B, Angelini, G D, Newby, A C & White, S J 2016, ' PI16 is a shear stress and inflammation-regulated inhibitor of MMP2 ', Scientific Reports, vol. 6, 39553 . https://doi.org/10.1038/srep39553

Raised endothelial shear stress is protective against atherosclerosis but such protection may be lost at sites of inflammation. We found that four splice variants of the peptidase inhibitor 16 (PI16) mRNA are among the most highly shear stress regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::646776df199ad8fcf5a8e93e9e8d1b1f

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