Zobrazeno 1 - 10
of 1 093
pro vyhledávání: '"New Approach Methodologies"'
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-23 (2024)
Abstract The merging of physiology and toxicokinetics, or pharmacokinetics, with computational modeling to characterize dosimetry has led to major advances for both the chemical and pharmaceutical research arenas. Driven by the mutual need to estimat
Externí odkaz:
https://doaj.org/article/d51b5f3019944a8da521a483167d657f
Autor:
Chukwuebuka Eze, Mathieu Vinken
Publikováno v:
FEBS Open Bio, Vol 14, Iss 9, Pp 1420-1440 (2024)
Currently, information on the toxicity profile of the majority of the identified e‐waste chemicals, while extensive and growing, is admittedly fragmentary, particularly at the cellular and molecular levels. Furthermore, the toxicity of the chemical
Externí odkaz:
https://doaj.org/article/a44fbbdf88104b019f18af8e72fc739f
Publikováno v:
Environment International, Vol 193, Iss , Pp 109112- (2024)
Acute fish toxicity (AFT) tests are performed in aquatic risk assessments of chemical compounds globally. However, the specific endpoint of in vivo AFT is based on the lethal concentration 50 (LC50), which is a serious challenge in terms of animal we
Externí odkaz:
https://doaj.org/article/c95bf97f851c43558e0d42c7919489ca
Autor:
Manuela Cassotta, Danila Cianciosi, Maria Elexpuru‐Zabaleta, Inaki Elio Pascual, Sandra Sumalla Cano, Francesca Giampieri, Maurizio Battino
Publikováno v:
Food Frontiers, Vol 5, Iss 3, Pp 1031-1062 (2024)
Abstract Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases a
Externí odkaz:
https://doaj.org/article/df9a140e25484db496c3b22884db6d86
Autor:
Victoria Ledbetter, Scott Auerbach, Logan J. Everett, Beena Vallanat, Anna Lowit, Gregory Akerman, William Gwinn, Leah C. Wehmas, Michael F. Hughes, Michael Devito, J. Christopher Corton
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Current methods for cancer risk assessment are resource-intensive and not feasible for most of the thousands of untested chemicals. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression b
Externí odkaz:
https://doaj.org/article/b05c465a5b4645b5b3f97f1d7d895f25
Autor:
Lynne T. Haber, Mark A. Bradley, Amanda N. Buerger, Holger Behrsing, Sabina Burla, Phillip W. Clapp, Scott Dotson, Casey Fisher, Keith R. Genco, Francis H. Kruszewski, Shaun D. McCullough, Kathryn E. Page, Vivek Patel, Nathan Pechacek, Clive Roper, Monita Sharma, Annie M. Jarabek
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The use of in vitro new approach methodologies (NAMs) to assess respiratory irritation depends on several factors, including the specifics of exposure methods and cell/tissue-based test systems. This topic was examined in the context of human health
Externí odkaz:
https://doaj.org/article/ca72051be402475ab543842c66886536
Autor:
Joy Ku, Prashanth Asuri
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Neurotoxicants are substances that can lead to adverse structural or functional effects on the nervous system. These can be chemical, biological, or physical agents that can cross the blood brain barrier to damage neurons or interfere with complex in
Externí odkaz:
https://doaj.org/article/2d28493bd0f14e67abb1f20dea485889
Publikováno v:
Frontiers in Lab on a Chip Technologies, Vol 3 (2024)
IntroductionThere have been relatively few attempts to quantitatively assess if, and in which areas, the use of non-animal methods (NAMs) is increasing in biomedical research and importantly, how this compares to the use of live animals.MethodsWe con
Externí odkaz:
https://doaj.org/article/216d675e3b184b9a84ff4029207aae35
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Externí odkaz:
https://doaj.org/article/b4702059ec7b4be29a7888fa198611f8
Publikováno v:
In Journal of Hazardous Materials 5 December 2024 480