Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nevzat Kazgan"'
Autor:
Xiaoling Li, Nevzat Kazgan
Publikováno v:
International Journal of Biological Sciences, Vol 7, Iss 5, Pp 575-587 (2011)
Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerge
Externí odkaz:
https://doaj.org/article/bbafb9ca50084bfc9923dd7f054e411b
Publikováno v:
Biology Open, Vol 2, Iss 12, Pp 1321-1323 (2013)
Summary The maintenance of energetic homeostasis in the face of limited available nutrients is a complex problem faced by all organisms. One important mechanism to maintain energetic homeostasis involves the activation of the energy sensor AMP-activa
Externí odkaz:
https://doaj.org/article/93e768c7ae824be9907a0e617e8cd267
Autor:
Erik C Johnson, Nevzat Kazgan, Colin A Bretz, Lawrence J Forsberg, Clare E Hector, Ryan J Worthen, Rob Onyenwoke, Jay E Brenman
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Organisms must utilize multiple mechanisms to maintain energetic homeostasis in the face of limited nutrient availability. One mechanism involves activation of the heterotrimeric AMP-activated protein kinase (AMPK), a cell-autonomous sensor to energe
Externí odkaz:
https://doaj.org/article/54b79cc2d8e344e29dd145c5f96bf302
Autor:
Takahiko Toyonaga, Nicole Chaumont, Neil D. Shah, Mark J. Koruda, Matt Kanke, Greg R Gipson, Michelle Hoffner O’Connor, Elisabeth A. Wolber, Dimitri G. Trembath, Terrence S. Furey, Jasmine B. Barrow, Wendy A. Pitman, Nevzat Kazgan, Nancy L. Allbritton, Matthew S Schaner, Paul A Cotney, Francisco A. Sylvester, Omar K. Trad, Praveen Sethupathy, Benjamin P. Keith, Shruti J Saxena, Timothy S. Sadiq, Shehzad Z. Sheikh
BACKGROUND. Crohn’s disease (CD) is highly heterogeneous, due in large part to variability in cellular processes that underlie the natural history of CD, thereby confounding effective therapy. There is a critical need to advance understanding of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7d423af630bb33d43122d4a5c5e6a9
https://doi.org/10.1101/307561
https://doi.org/10.1101/307561
Autor:
M. Andrea Azcarate-Peril, Xiaoling Li, Ajay S. Gulati, Alicia S. Wellman, David C. Fargo, Agnieszka Czopik, Xiaojiang Xu, Nevzat Kazgan, Michael J. Shanahan, Mallikarjuna R. Metukuri, Willa Chen, Leonard Guarente, Ashley Kang, Qing Xu, Natalie S.X. Ren
Publikováno v:
PMC
Intestinal epithelial homeostasis is maintained by complex interactions among epithelial cells, commensal gut microorganisms, and immune cells. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD), but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f1451abd6b14ea8b21ae9e5ed72cb8
http://hdl.handle.net/1721.1/118956
http://hdl.handle.net/1721.1/118956
Publikováno v:
Molecular Biology of the Cell
In this study, we utilized genetic and cell biological approaches to evaluate potential functions for the AMPKα C-terminus. We identify a critical new function for the carboxy-terminal amino acids of AMPKα in vivo, which affects AMPKα subcellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b276aaa52fbfe9791941ef5ee05bc2b
https://doi.org/10.1091/mbc.e10-04-0347
https://doi.org/10.1091/mbc.e10-04-0347
Publikováno v:
Biology Open
Biology Open, Vol 2, Iss 12, Pp 1321-1323 (2013)
Biology Open, Vol 2, Iss 12, Pp 1321-1323 (2013)
Summary The maintenance of energetic homeostasis in the face of limited available nutrients is a complex problem faced by all organisms. One important mechanism to maintain energetic homeostasis involves the activation of the energy sensor AMP-activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a50af4cb195f32eb5e0a5b12b687f8e
http://europepmc.org/articles/PMC3863416
http://europepmc.org/articles/PMC3863416
Autor:
Jing Lu, Iván L. Csanaky, Anuradha Rao, Paul A. Dawson, Xiaoling Li, Andrew J. Lickteig, Aparna Purushotham, Yingming Zhao, Nevzat Kazgan, Mallikarjuna R. Metukuri, Matthew Pratt–Hyatt, Sangkyu Lee
Publikováno v:
Gastroenterology. 146(4)
Background & Aims Sirtuin 1 (SIRT1), the most conserved mammalian oxidized nicotinamide adenine dinucleotide–dependent protein deacetylase, is an important metabolic sensor in many tissues. However, little is known about its role in the small intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2c5295573ef72fcca82be85cf02462
https://pubmed.ncbi.nlm.nih.gov/24566103
https://pubmed.ncbi.nlm.nih.gov/24566103
Autor:
Nevzat Kazgan, Xiaoling Li
Publikováno v:
International Journal of Biological Sciences
Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de6b90394990d9d470e8e1c9d047c94
https://pubmed.ncbi.nlm.nih.gov/21614150
https://pubmed.ncbi.nlm.nih.gov/21614150
Publikováno v:
The Journal of biological chemistry. 279(15)
Macroautophagy is the major mechanism that eukaryotes use to recycle cellular components during stressful conditions. We have shown previously that the Atg12-Atg5 conjugation system, required for autophagosome formation in yeast, is necessary for Dic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44e8475e980c84dbcb302b742843624
https://pubmed.ncbi.nlm.nih.gov/14736886
https://pubmed.ncbi.nlm.nih.gov/14736886