Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nevin Witman"'
Autor:
Jonathan Al-Saadi, Mathias Waldén, Mikael Sandell, Jesper Sohlmér, Rikard Grankvist, Ida Friberger, Agneta Andersson, Mattias Carlsten, Kenneth Chien, Johan Lundberg, Nevin Witman, Staffan Holmin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101225- (2024)
Heart failure has a poor prognosis and no curative treatment exists. Clinical trials are investigating gene- and cell-based therapies to improve cardiac function. The safe and efficient delivery of these therapies to solid organs is challenging. Here
Externí odkaz:
https://doaj.org/article/9aef628314494ff8911503063a61ba31
Autor:
Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cardiogenic growth factors play important roles in heart development. Placental growth factor (PLGF) has previously been reported to have angiogenic effects; however, its potential role in cardiogenesis has not yet been determined. We analyz
Externí odkaz:
https://doaj.org/article/e6da8a6cf91241599f130c97c715953e
Autor:
Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f7261ffe7a7a4b8491b2ec59ef14a97b
Autor:
Yao Tan, Tingting Lu, Ying Chen, Nevin Witman, Bingqian Yan, Li Yang, Minglu Liu, Yiqi Gong, Xuefeng Ai, Runjiao Luo, Huijing Wang, Wei Wang, Wei Fu
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Engineering a conduction‐consistent cardiac patch has direct implications to biomedical research. However, there is difficulty in obtaining and maintaining a system that allows researchers to study physiologically relevant cardiac developm
Externí odkaz:
https://doaj.org/article/daf1d36e827b44b798d5e86cd6a95e25
Autor:
Erwin De Genst, Kylie S. Foo, Yao Xiao, Eduarde Rohner, Emma de Vries, Jesper Sohlmér, Nevin Witman, Alejandro Hidalgo, Terje R. S. Kolstad, William E. Louch, Susanne Pehrsson, Andrew Park, Yasuhiro Ikeda, Xidan Li, Lorenz M. Mayr, Kate Wickson, Karin Jennbacken, Kenny Hansson, Regina Fritsche-Danielson, James Hunt, Kenneth R. Chien
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here the authors use modified RNA and VHH libraries to generate intrabodies that target dysregulated interactions between two calcium handling proteins in failing cardiomyocytes. Heart specific expression of the intrabodies in a murine heart failure
Externí odkaz:
https://doaj.org/article/41820d2e39ea4787978141037e15dc1e
Autor:
Yao Tan, Ying Chen, Tingting Lu, Nevin Witman, Bingqian Yan, Yiqi Gong, Xuefeng Ai, Li Yang, Minglu Liu, Runjiao Luo, Huijing Wang, Stefano Ministrini, Wei Dong, Wei Wang, Wei Fu
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
The healthy human heart has special directional arrangement of cardiomyocytes and a unique electrical conduction system, which is critical for the maintenance of effective contractions. The precise arrangement of cardiomyocytes (CMs) along with condu
Externí odkaz:
https://doaj.org/article/dcc034a0f8a54c638e62a3da387d9d58
Autor:
Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara, Kenneth R. Chien
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Abstract Background The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be clarified. Previous st
Externí odkaz:
https://doaj.org/article/01255acd28e041f6acfa35e58ea55910
Autor:
Ran Yang, Alexander Goedel, Yu Kang, Chenyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, Peter J. Gruber, Yao Xiao, Chikai Zhou, Nevin Witman, Elif Eroglu, Chuen-Yan Leung, Yongchang Chen, Jianping Fu, Weizhi Ji, Fredrik Lanner, Yuyu Niu, Kenneth R. Chien
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Human and murine embryonic development has disparities, highlighting the need for primate systems. Here, the authors construct a post-implantation transcriptional atlas from non-human primate embryos and show ISL1 controls a gene regulatory network i
Externí odkaz:
https://doaj.org/article/7dccdc1bc5d94178bbec12844860f1f9
Autor:
Yingnan Geng, Huichuan Duan, Liang Xu, Nevin Witman, Bingqian Yan, Zheyuan Yu, Huijing Wang, Yao Tan, Liqin Lin, Dong Li, Shanshan Bai, Regina Fritsche-Danielson, Jie Yuan, Kenneth Chien, Min Wei, Wei Fu
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen sc
Externí odkaz:
https://doaj.org/article/d333b9fe3c4e40e28331a8e504c5dc91
Autor:
Fei Yu, Nevin Witman, Dan Yan, Siyi Zhang, Meng Zhou, Yan Yan, Qinke Yao, Feixue Ding, Bingqian Yan, Huijing Wang, Wei Fu, Yang Lu, Yao Fu
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-20 (2020)
Abstract Background Fat grafting, as a standard treatment for numerous soft tissue defects, remains unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are promising candidates for cell-assisted therapy to improve graft s
Externí odkaz:
https://doaj.org/article/35a1caeb7dcf44ddaefa82ac0807b297