Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Neville W Knuckey"'
Autor:
Diego Milani, Megan C Bakeberg, Jane L Cross, Vince W Clark, Ryan S Anderton, David J Blacker, Neville W Knuckey, Bruno P Meloni
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193884 (2018)
We have previously demonstrated that arginine-rich and poly-arginine peptides possess potent neuroprotective properties, with poly-arginine peptide R18 identified as being highly effective at reducing infarct volume following middle cerebral artery o
Externí odkaz:
https://doaj.org/article/55586b60a51e4c1bba38d80f460e6beb
Autor:
Gurkiran Kaur Flora, Ryan S. Anderton, Bruno P. Meloni, Gilles J. Guillemin, Neville W. Knuckey, Gabriella MacDougall, Vance Matthews, Sherif Boulos
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e12842- (2023)
Externí odkaz:
https://doaj.org/article/e097b904f3e44e5cb97267dff0742e02
Publikováno v:
Biochemistry and Biophysics Reports, Vol 31, Iss , Pp 101305- (2022)
Our laboratory focuses on the development of novel neuroprotective cationic peptides, such poly-arginine-18 (R18: 18-mer of l-arginine; net charge +18) and its d-enantiomer R18D in stroke and other brain injuries. In the clinical development of R18/R
Externí odkaz:
https://doaj.org/article/28aecd922d6f4b9ab7fa148358ae958f
Autor:
Gabriella MacDougall, Ryan S. Anderton, Frank L. Mastaglia, Neville W. Knuckey, Bruno P. Meloni
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 17-33 (2019)
Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available neu
Externí odkaz:
https://doaj.org/article/155a64dbda5f4903b22592a84aac04bc
Publikováno v:
Journal of Thrombosis and Thrombolysis. 54:172-182
The poly-arginine peptides R18D and R18 represent novel potential neuroprotective treatments for acute ischaemic stroke. Here we examined whether R18D and R18 had any significant effects on the thrombolytic activity of alteplase (tPA) and tenecteplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d7108e9e930fac121d332520be84234
https://doi.org/10.1007/s11239-022-02642-4
https://doi.org/10.1007/s11239-022-02642-4
Autor:
Gabriella MacDougall, Ryan S. Anderton, Amy Trimble, Frank L. Mastaglia, Neville W. Knuckey, Bruno P. Meloni
Publikováno v:
Molecules, Vol 25, Iss 13, p 2977 (2020)
Recent studies have highlighted that a novel class of neuroprotective peptide, known as cationic arginine-rich peptides (CARPs), have intrinsic neuroprotective properties and are particularly effective anti-excitotoxic agents. As such, the present st
Externí odkaz:
https://doaj.org/article/052373e68f1d49f6b407a510230b0137
Autor:
Kirk W. Feindel, Diego Milani, Vince W. Clark, Bruno P. Meloni, Neville W. Knuckey, Adam B. Edwards, Ryan S. Anderton, Michael Bynevelt, David Blacker
Publikováno v:
Neurochemical Research. 46:1166-1176
Poly-arginine peptides R18 and R18D have previously been demonstrated to be neuroprotective in ischaemic stroke models. Here we examined the proteolytic stability and efficacy of R18 and R18D in reducing infarct core growth and preserving the ischaem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050b40c2e26ffc1d406f295e6b749710
https://doi.org/10.1007/s11064-021-03251-y
https://doi.org/10.1007/s11064-021-03251-y
Publikováno v:
Expert Review of Neurotherapeutics. 20:887-890
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4464d1e8153e0638649cdc22b43289a7
https://doi.org/10.1080/14737175.2020.1788390
https://doi.org/10.1080/14737175.2020.1788390
Publikováno v:
Brain Sciences, Vol 8, Iss 8, p 147 (2018)
Perinatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality and morbidity in neonates, with survivors suffering significant neurological sequelae including cerebral palsy, epilepsy, intellectual disability and autism spectrum di
Externí odkaz:
https://doaj.org/article/d5f93d2a398b4b65a53c90346883571f
Autor:
Sherif Boulos, Bruno P. Meloni, Peter G. Arthur, Bernadette Majda, Christina Bojarski, Neville W. Knuckey
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 1, Pp 54-64 (2007)
We previously reported that cyclophilin A protein is up-regulated in cortical neuronal cultures following several preconditioning treatments. In the present study, we have demonstrated that adenoviral-mediated over-expression of cyclophilin A in rat
Externí odkaz:
https://doaj.org/article/31f1aab8afdd49ae927354f8e9497508