Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Neville Sanjana"'
Autor:
Mateusz Legut, Maria Guarino, Xinhe Xue, Congyi Lu, Radha Vyas, Catherine S. Diefenbach, Neville Sanjana
Publikováno v:
Blood. 140:10235-10236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f707a65aeeb2437742a461bd7f453ec
https://doi.org/10.1182/blood-2022-163230
https://doi.org/10.1182/blood-2022-163230
Publikováno v:
Cancer Research. 82:659-659
SHP2 (PTPN11) is required for RAS activation, acting upstream of SOS1/2. Allosteric SHP2 inhibitors (SHP2is) stabilize auto-inhibition mediated by N-SH2/PTP interactions and prevent its activation by upstream stimuli. SHP2is impair the proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87d4d6cebe621079f79de92f04afd69a
https://doi.org/10.1158/1538-7445.am2022-659
https://doi.org/10.1158/1538-7445.am2022-659