Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Neville J, Howard"'
Autor:
Norbert O. Temajo, Neville J. Howard
Publikováno v:
AIMS Allergy and Immunology, Vol 1, Iss 2, Pp 50-61 (2017)
To happen, autoimmunity in man requires triggering by environmental factors: the viruses and cellular stress, in genetically primed individuals. The viruses and stress are operatives in this scene as stimuli for the activation of the transcription fa
Autor:
Norbert O. Temajo, Neville J. Howard
Publikováno v:
Immunologic Research. 60:208-218
The viruses are salient in the roles of environmental factors that trigger autoimmunity. The virus realizes its effects by the power of its induction of heat shock proteins (HSPs) as well as by the viral IE-axis-mediated conversion of organ epithelia
Autor:
Adrian van Rhijn, Emma L. Edghill, Ewan R. Pearson, G. Jan Bruining, Deborah J G Mackay, Jerry Wales, Frances M. Ashcroft, Jennifer F. Antcliff, I. Karen Temple, Javier Aisenberg, Pål R. Njølstad, Shubha Srinivasan, Anna L. Gloyn, Shaun Gorman, Sian Ellard, Timothy M. Frayling, Peter Proks, Zdenek Sumnik, Neville J. Howard, Penelope M. Clark, Julian P.H. Shield, Jose M. C. L Silva, Janne Molnes, Annabelle S. Slingerland, Andrew T. Hattersley
Publikováno v:
New England Journal of Medicine, 350, 20-31. Massachussetts Medical Society
University of Bristol-PURE
University of Dundee
University of Bristol-PURE
University of Dundee
BACKGROUND: Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin treatment. In most, the cause is unknown. Because ATP-sensitive potassium (K(ATP)) channels mediate glucose-stimulated ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef19a3cfae21ca5da6dd81a00edd376
https://ora.ox.ac.uk/objects/uuid:bed79a6b-e297-4803-994f-9cc2f6bbe95f
https://ora.ox.ac.uk/objects/uuid:bed79a6b-e297-4803-994f-9cc2f6bbe95f
Autor:
Lilian Jackson, Melinda K. Morrison, Angela C Middlehurst, Charles F. Verge, Neville J. Howard, Bruce R. King, Michelle M Jack, Natalie Govind, Karen Jameson, DM Wajira S Bandara
Publikováno v:
Pediatric Diabetes. 13:647-651
Objective To evaluate the effect of a diabetes awareness campaign on the incidence of diabetic ketoacidosis (DKA) at the first presentation of type 1 diabetes in children (0–18 yr). Methods This study was a controlled population intervention study
Autor:
Norbert O. Temajo, Neville J. Howard
Publikováno v:
Autoimmunity Reviews. 11:653-658
An autoimmune disease (AD) occurs in a situation where an individual's protective immune system attacks and destroys the individual's own tissues and organ(s), causing a recognizable syndrome(s). The viruses feature in the triggering of autoimmune di
Autor:
Norbert O. Temajo, Neville J. Howard
Publikováno v:
Autoimmunity Reviews. 8:364-368
It is well established that both DR and DQ genes are involved in type 1 diabetes (T1D) -susceptibility. But how the DR and DQ molecules contrive to effect collectively the same function of T1D predisposition remains unexplained. We advance the Co-ope
Autor:
Stephen Hing, Albert K. Chan, Maike C. Eppens, Neville J. Howard, Janine Cusumano, Kim C. Donaghue, Martin Silink, Maria E. Craig
Publikováno v:
Diabetes Care. 29:1300-1306
OBJECTIVE—To compare the prevalence of diabetes complications and their risk factors in youth with type 1 versus type 2 diabetes. RESEARCH DESIGN AND METHODS—We performed a comparative clinic-based study of 1,433 patients with type 1 diabetes and
Autor:
Martin Silink, Claire Taylor, Craig E. Taplin, Neville J. Howard, Patricia Crock, Maria E. Craig, Margaret Lloyd
Publikováno v:
Medical Journal of Australia. 183:243-246
Objectives: To determine the incidence of childhood type 1 diabetes mellitus (T1 DM) in New South Wales from 1997 to 2002; to compare with previously published rates (1990-1996); and to analyse trends in incidence from 1990 to 2002. Design, setting a
Autor:
Maria E. Craig, Janine Cusumano, Jennifer W. Lee, Fauzia Mohsin, Stephen Hing, Neville J. Howard, Albert K. Chan, Kim C. Donaghue, Martin Silink
Publikováno v:
Diabetes Care. 28:1974-1980
OBJECTIVE—Since the Diabetes Control and Complications Trial, diabetes management goals have changed. The aims of the present study were to assess complication rates, including nerve abnormalities, in adolescents from 1990 to 2002 and to investigat
Autor:
Louise A. Baur, Kim C. Donaghue, Campbell H. Thompson, Fiona E. Arrowsmith, Julie A Ward, Andrew H. Ling, Neville J. Howard
Publikováno v:
Pediatric Diabetes. 4:126-131
Background: In the non-diabetic population, intramyocellular lipid (IMCL) accumulation is associated with obesity and poor muscle oxygen supply. IMCL levels are increased in type 1 diabetes, but their significance is less clear. Methods: We studied a