Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nevien Ismail"'
Autor:
Jacqueline Araújo Fiuza, Sreenivas Gannavaram, Soraya Torres Gaze, Letícia Gambogi de Ornellas, Érica Alessandra Alves, Nevien Ismail, Hira Lal Nakhasi, Rodrigo Correa-Oliveira
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Vaccination with live attenuated Leishmania parasites such as centrin deleted Leishmania donovani (LdCen −/− ) against visceral leishmaniasis has been reported extensively. The protection induced by LdCen −/− parasites was mediated b
Externí odkaz:
https://doaj.org/article/f844d70d807047be8f1bd7553d6cd98e
Autor:
Subir Karmakar, Greta Volpedo, Wen-Wei Zhang, Patrick Lypaczewski, Nevien Ismail, Fabiano Oliveira, James Oristian, Claudio Meneses, Sreenivas Gannavaram, Shaden Kamhawi, Shinjiro Hamano, Jesus G. Valenzuela, Greg Matlashewski, Abhay R. Satoskar, Ranadhir Dey, Hira L. Nakhasi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world. Currently, there is a lack of eff
Externí odkaz:
https://doaj.org/article/26413e213d76441788ba0d0d2b589f6a
Autor:
Subir Karmakar, Nevien Ismail, Fabiano Oliveira, James Oristian, Wen Wei Zhang, Swarnendu Kaviraj, Kamaleshwar P. Singh, Abhishek Mondal, Sushmita Das, Krishna Pandey, Parna Bhattacharya, Greta Volpedo, Sreenivas Gannavaram, Monika Satoskar, Sanika Satoskar, Rajiv M. Sastry, Timur Oljuskin, Telly Sepahpour, Claudio Meneses, Shinjiro Hamano, Pradeep Das, Greg Matlashewski, Sanjay Singh, Shaden Kamhawi, Ranadhir Dey, Jesus G. Valenzuela, Abhay Satoskar, Hira L. Nakhasi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Karmakar et al produced a dermotropic, live attenuated centrin gene-deleted Leishmania major (LmCen −/− ) vaccine against Visceral Leishmaniasis (VL). They demonstrated in hamsters that a single intradermal injection confers robust and durable pr
Externí odkaz:
https://doaj.org/article/b17a11a8c0a341a0abe1473e6b12a4ae
Autor:
Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K. Dagur, Adovi Akue, Mark KuKuruga, Hira L. Nakhasi
Publikováno v:
Pathogens, Vol 12, Iss 4, p 534 (2023)
No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted L. donovani (LdCen−/−) parasite vaccine has been shown to induce robust innate immunity and provide protection in animal models. Toll-like recepto
Externí odkaz:
https://doaj.org/article/ce954f59d47649aeac64fc072e4e623b
Autor:
Nevien Ismail, Subir Karmakar, Parna Bhattacharya, Telly Sepahpour, Kazuyo Takeda, Shinjiro Hamano, Greg Matlashewski, Abhay R. Satoskar, Sreenivas Gannavaram, Ranadhir Dey, Hira L. Nakhasi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene-deleted parasite strain (LmCen-/-) that ind
Externí odkaz:
https://doaj.org/article/d922fe69acf54257873a8b09ab04cc74
Autor:
Wen-Wei Zhang, Subir Karmakar, Sreenivas Gannavaram, Ranadhir Dey, Patrick Lypaczewski, Nevien Ismail, Abid Siddiqui, Vahan Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza-Vieira, Claudio Meneses, James Oristian, Tiago D. Serafim, Abu Musa, Risa Nakamura, Noushin Saljoughian, Greta Volpedo, Monika Satoskar, Sanika Satoskar, Pradeep K. Dagur, J. Philip McCoy, Shaden Kamhawi, Jesus G. Valenzuela, Shinjiro Hamano, Abhay R. Satoskar, Greg Matlashewski, Hira L. Nakhasi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, the authors engineer an attenuated knock-out Leishmania (LmCen −/−) vaccine that is safe in immunocompromised mice and induces an immune response and protection similar to leishmanization with wild-type Leishmania. Since LmCen −/− is an
Externí odkaz:
https://doaj.org/article/a50605a064c049859dfcd1fb76a10dad
Autor:
Parna Bhattacharya, Nevien Ismail, Ankit Saxena, Sreenivas Gannavaram, Ranadhir Dey, Timur Oljuskin, Adovi Akue, Kazuyo Takeda, James Yu, Subir Karmakar, Pradeep K Dagur, John Philip McCoy, Hira L Nakhasi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010224 (2022)
BackgroundNeutrophils are involved in the initial host responses to pathogens. Neutrophils can activate T cell responses either independently or through indirect involvement of Dendritic cells (DCs). Recently we have demonstrated direct neutrophil-T
Externí odkaz:
https://doaj.org/article/2d1df771608e44698a707b8c704a0dad
Autor:
Sreenivas Gannavaram, John Torcivia, Lusine Gasparyan, Amit Kaul, Nevien Ismail, Vahan Simonyan, Hira L. Nakhasi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leis
Externí odkaz:
https://doaj.org/article/d976c0ed5ec047e4a8b50c73f5058f1b
Autor:
Sreenivas Gannavaram, Parna Bhattacharya, Abid Siddiqui, Nevien Ismail, Subha Madhavan, Hira L. Nakhasi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
No vaccine exists against visceral leishmaniasis. Toward developing vaccines against VL, we have reported previously on the immunogenicity of live attenuated LdCen−/− parasites in animal models. Immunization with LdCen−/– parasites has been s
Externí odkaz:
https://doaj.org/article/b8906110411f4dfebfb8fee49feffa84
Autor:
Rakesh K. Singh, Sreenivas Gannavaram, Nevien Ismail, Amit Kaul, Mallikarjuna Rao Gedda, Hira L. Nakhasi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The protozoan parasite Leishmania has evolved several strategies to undermine host defense mechanisms by inducing Th2-type adaptive immunity and suppressing effector functions of Th1 phenotype. In our earlier studies, using centrin gene-deleted Leish
Externí odkaz:
https://doaj.org/article/e62c7f301421406480565c4c986c3600