Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nevena, Mollova"'
Autor:
Clinton K. Matson, Thomas Kenney, Bart H. Steiner, Chloe R. Deodato, Anella Yahiaoui, Claudia A. Rubio, Julie T. Chan, Nevena Mollova, Kathleen S. Keegan, Chandrasekar Venkataramani
Publikováno v:
Cancer Research. 82:3696-3696
MCL1 is an anti-apoptotic member of the BCL2 family of proteins. These anti-apoptotic proteins prevent caspase-mediated cell apoptosis by binding to the pro-apoptotic proteins BIM, BAK and BAX, thereby inhibiting the formation of pores on the outer m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5924c561235990b846e35b57d250718
https://doi.org/10.1158/1538-7445.am2022-3696
https://doi.org/10.1158/1538-7445.am2022-3696
Publikováno v:
Poster Presentations.
Background Inhibition of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway has demonstrated efficacy in immune-mediated diseases and has been identified as a therapeutic target for the treatment of rheumatoid arth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44bff10c4b5b0e72e8c57748a1125296
https://doi.org/10.1136/annrheumdis-2019-eular.3361
https://doi.org/10.1136/annrheumdis-2019-eular.3361
Autor:
Marcel A.G. van der Heyden, Sridharan Rajamani, Alexandre Bossu, Veronique M.F. Meijborg, Rosanne Varkevisser, Albert Dunnink, Nevena Mollova, Marien J C Houtman, Luiz Belardinelli, Jacques M.T. de Bakker, H D M Beekman, Marc A. Vos
Publikováno v:
British Journal of Pharmacology. 175:2470-2482
© 2018 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e08cf50eb144f833877c51eb689a311
https://doi.org/10.1111/bph.14217
https://doi.org/10.1111/bph.14217
Autor:
Elfatih Elzein, Cindy Hong Li, Daniel Soohoo, Britton Kenneth Corkey, Chandru Venkataramani, Xiao-Jun Li, Manoj C. Desai, Nesrine El-Bizri, Haibo Jiang, Kobayashi Tetsuya, Nevena Mollova, Sridharan Rajamani, Jason K. Perry, Arvinder Dhalla, Thao Perry, Xiaofen Li, Robert G. Strickley, Notte Gregory, Gerry Rhodes, Ryoko Hirakawa, Luiz Belardinelli, Eve-Irene Lepist, Parkhill Eric Q, Jeff Zablocki, Oliver L. Saunders, Lu Yafan, Rao Kalla, Dmitry Koltun, Cheng Xie, Gongxin Liu, Wei-Qun Wang, Kris M. Kahlig, Bernard P. Murray, Michael Graupe, Guerrero Juan A, Martinez Ruben, Mark Osier, Lufei Hu
Publikováno v:
Journal of Medicinal Chemistry. 59:9005-9017
Late sodium current (late INa) is enhanced during ischemia by reactive oxygen species (ROS) modifying the Nav 1.5 channel, resulting in incomplete inactivation. Compound 4 (GS-6615, eleclazine) a novel, potent, and selective inhibitor of late INa, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d94b0c7942e17b573ee6f2bc8434003
https://doi.org/10.1021/acs.jmedchem.6b00939
https://doi.org/10.1021/acs.jmedchem.6b00939
Autor:
Donglin Guo, Nevena Mollova, Elfatih Elzein, Sridharan Rajamani, Nesrine El-Bizri, Gongxin Liu, Luiz Belardinelli, Kristopher M. Kahlig, Jeff Zablocki, Xiao-Liang Chen, Cindy Hong Li
Publikováno v:
British Journal of Pharmacology. 173:3088-3098
Background and Purpose Enhanced late Na+ current (late INa) in the myocardium is pro-arrhythmic. Inhibition of this current is a promising strategy to stabilize ventricular repolarization and suppress arrhythmias. Here, we describe GS-6615, a selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f37746a20cc21acfbbbaa6363f39e04
https://doi.org/10.1111/bph.13563
https://doi.org/10.1111/bph.13563
Autor:
Elfatih Elzein, Kobayashi Tetsuya, Brian Stafford, Ryoko Hirakawa, Nevena Mollova, Sridharan Rajamani, Belem Avila, Catherine Smith-Maxwell, Thao Perry, Lin Wu, Jennifer Tang, Jeff Zablocki, Xiaofen Li, Wei-Qun Wang, Dmitry Koltun, Parkhill Eric Q, Robert Jiang, Arvinder Dhalla, Luiz Belardinelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3207-3211
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fe40fe24221536f142ea4df6dd02ec
https://doi.org/10.1016/j.bmcl.2016.03.096
https://doi.org/10.1016/j.bmcl.2016.03.096
Autor:
Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3202-3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef515260de6068eed1fe5a0177f0bb65
https://doi.org/10.1016/j.bmcl.2016.03.101
https://doi.org/10.1016/j.bmcl.2016.03.101
Publikováno v:
Gastroenterology. 158:S-1212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47997d0a3a9304188d2c2aa72f78df40
https://doi.org/10.1016/s0016-5085(20)33690-8
https://doi.org/10.1016/s0016-5085(20)33690-8
Publikováno v:
Journal of Crohn's and Colitis. 14:S409-S409
Background Inhibitors of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway have demonstrated efficacy in the treatment of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Differences in selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae28d4d3b4a5b62b0d9d6cb0c21053c
https://doi.org/10.1093/ecco-jcc/jjz203.589
https://doi.org/10.1093/ecco-jcc/jjz203.589
Autor:
C. Pohlmeyer, Z.-H. Cui, J. A. Di Paolo, S. Zaboli, A. Shauf, Nevena Mollova, Randall Mark Jones, Igor Mikaelian, Pei Han, Astrid S. Clarke
Publikováno v:
Rheumatoid arthritis – non biologic treatment and small molecules.
Background Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterised by immune system hyperactivation leading to the production of autoantibodies and immune attack on multiple organs including the skin and kidneys. High l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::253eec6a960895ab0b586085829bb095
https://doi.org/10.1136/annrheumdis-2018-eular.3367
https://doi.org/10.1136/annrheumdis-2018-eular.3367