Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nevan, Krogan"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Persisting replication intermediates can confer mitotic catastrophe. Loss of the fission yeast telomere protein Taz1 (ortholog of mammalian TRF1/TRF2) causes telomeric replication fork (RF) stalling and consequently, telomere entanglements t
Externí odkaz:
https://doaj.org/article/ad170ab9b6574d46bfa6d79292265323
Autor:
Rajaa Sebaa, Jeff Johnson, Chantal Pileggi, Michaela Norgren, Jian Xuan, Yuka Sai, Qiang Tong, Izabella Krystkowiak, Emma Bondy-Chorney, Norman E. Davey, Nevan Krogan, Michael Downey, Mary-Ellen Harper
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 35-49 (2019)
Objective: Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a
Externí odkaz:
https://doaj.org/article/afe2fd5e16c047dbb8b785f6f7720c7f
Autor:
Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Díaz, André Haman, Trang Hoang, Daniel Sinnett, Christian Beauséjour, Serge McGraw, Noël J.-M. Raynal
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identification of a specific c
Externí odkaz:
https://doaj.org/article/bdecc4d44be747e18ba1c9bfae4d8fcf
Autor:
Charlotte Eaton, Lauro Avalos, S. John Liu, Tim Casey-clyde, Paola Bisignano, Calixto-Hope Lucas, Erica Stevenson, Abrar Choudhury, Harish Vasudevan, Stephen Magill, Nevan Krogan, Javier Villanueva-Meyer, Danielle Swaney, David Raleigh
Meningiomas are the most common primary intracranial tumors and are associated with inactivation of the tumor suppressor NF2/Merlin, but one-third of meningiomas retain Merlin expression and typically have favorable clinical outcomes. Biochemical mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dffc7486996a77b08acad55eb7732077
https://doi.org/10.21203/rs.3.rs-2577844/v1
https://doi.org/10.21203/rs.3.rs-2577844/v1
When faced with a DNA double strand break, cells activate an elaborate signaling cascade called the DNA damage response to protect genomic integrity. To identify novel factors that modulate the DNA damage response to DNA double strand breaks, we perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d305b448c08ad2fd3fc8c20728bc46f
https://doi.org/10.1101/2023.02.26.530133
https://doi.org/10.1101/2023.02.26.530133
Persisting replication intermediates can confer mitotic catastrophe if left unresolved. Loss of the fission yeast telomere protein Taz1 (ortholog of mammalian TRF1/TRF2) causes telomeric replication fork stalling and in turn, telomere entanglements t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56dd27bca35d22bb55b6b862b46c884b
https://doi.org/10.1101/2023.02.24.529917
https://doi.org/10.1101/2023.02.24.529917
Autor:
Anthony L Shiver, Hendrik Osadnik, George Kritikos, Bo Li, Nevan Krogan, Athanasios Typas, Carol A Gross
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006902 (2017)
[This corrects the article DOI: 10.1371/journal.pgen.1006124.].
Externí odkaz:
https://doaj.org/article/891df7df3c68438897b9d9817b4d28a0
Autor:
Irene P. Chen, James E. Longbotham, Sarah McMahon, Rahul K. Suryawanshi, Mir M. Khalid, Taha Y. Taha, Takako Tabata, Jennifer M. Hayashi, Frank W. Soveg, Jared Carlson-Stevermer, Meghna Gupta, Meng Yao Zhang, Victor L. Lam, Yang Li, Zanlin Yu, Erron W. Titus, Amy Diallo, Jennifer Oki, Kevin Holden, Nevan Krogan, Danica Galonić Fujimori, Melanie Ott
Publikováno v:
Cell reports, vol 40, iss 3
bioRxiv
bioRxiv
Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here we show that BET proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5372b20c38023d14b59bc671f5a2a48
https://escholarship.org/uc/item/2pf842c8
https://escholarship.org/uc/item/2pf842c8
Autor:
Tobias Moll, Valerie Odon, Calum Harvey, Mark O Collins, Andrew Peden, John Franklin, Emily Graves, Jack NG Marshall, Cleide dos Santos Souza, Sai Zhang, Lydia Castelli, Guillaume Hautbergue, Mimoun Azzouz, David Gordon, Nevan Krogan, Laura Ferraiuolo, Michael P Snyder, Pamela J Shaw, Jan Rehwinkel, Johnathan Cooper-Knock
Publikováno v:
Life science alliance. 6(1)
New therapeutic targets are a valuable resource for treatment of SARS-CoV-2 viral infection. Genome-wide association studies have identified risk loci associated with COVID-19, but many loci are associated with comorbidities and are not specific to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecbd99e83491b15b3da18b6f3c5e1d7
https://pubmed.ncbi.nlm.nih.gov/35291294
https://pubmed.ncbi.nlm.nih.gov/35291294
Autor:
Federico A De Maio, Guillermo Risso, Nestor G Iglesias, Priya Shah, Berta Pozzi, Leopoldo G Gebhard, Pablo Mammi, Estefania Mancini, Marcelo J Yanovsky, Raul Andino, Nevan Krogan, Anabella Srebrow, Andrea V Gamarnik
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005841 (2016)
Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells, enabling viral RNA replication and counteracting host antiviral responses. Here, we demonstrate a novel function of NS5 in the nucleus where it interferes with cell
Externí odkaz:
https://doaj.org/article/869b087a2ada47b1b0bc064fd1f93040