Zobrazeno 1 - 10
of 1 781
pro vyhledávání: '"Nevado, P."'
Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed: traditional masked
Externí odkaz:
http://arxiv.org/abs/2403.19802
Contemporary large language models (LLMs) may have utility for processing unstructured, narrative free-text clinical data contained in electronic health records (EHRs) -- a particularly important use-case for mental health where a majority of routine
Externí odkaz:
http://arxiv.org/abs/2403.19790
Autor:
Taylor, Niall, Ghose, Upamanyu, Rohanian, Omid, Nouriborji, Mohammadmahdi, Kormilitzin, Andrey, Clifton, David, Nevado-Holgado, Alejo
The entry of large language models (LLMs) into research and commercial spaces has led to a trend of ever-larger models, with initial promises of generalisability, followed by a widespread desire to downsize and create specialised models without the n
Externí odkaz:
http://arxiv.org/abs/2402.10597
Autor:
Lorge, Isabelle, Joyce, Dan W., Taylor, Niall, Nevado-Holgado, Alejo, Cipriani, Andrea, Kormilitzin, Andrey
Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where despite treatment, they continue to experience significant burden. We sought to develop a Large L
Externí odkaz:
http://arxiv.org/abs/2402.07645
Autor:
Poddar, Asmita, Uzun, Vladimir, Tunbridge, Elizabeth, Haerty, Wilfried, Nevado-Holgado, Alejo
Splice sites play a crucial role in gene expression, and accurate prediction of these sites in DNA sequences is essential for diagnosing and treating genetic disorders. We address the challenge of splice site prediction by introducing DeepDeCode, an
Externí odkaz:
http://arxiv.org/abs/2311.12884
Publikováno v:
BMC Pediatrics, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background The 2q31 deletion results in a distinct phenotype characterized by varying degrees of developmental delay, short stature, facial dysmorphism, and variable limb defects. Dysmorphic features include microcephaly, downslanting palpeb
Externí odkaz:
https://doaj.org/article/091d90f3fd75443a9802816d14013fc2
Autor:
Iván Cheng-Sánchez, Katherine Gosselé, Leonardo Palaferri, Eleen Laul, Gionata Riccabella, Rajiv K. Bedi, Yaozong Li, Anna Müller, Ivan Corbeski, Amedeo Caflisch, Cristina Nevado
Publikováno v:
JACS Au, Vol 4, Iss 9, Pp 3466-3474 (2024)
Externí odkaz:
https://doaj.org/article/18493fc3cacd4fa08e19c9339093db56
Publikováno v:
English Studies at NBU, Vol 10, Iss 1, Pp 133-158 (2024)
There were 6,491,502 foreign residents living in Spain in January 2024, a number that indicates a significant increase since the beginning of the 21st century. Among this foreign population, the largest communities are Moroccans, Romanians and Britis
Externí odkaz:
https://doaj.org/article/4605ef4ca4514a3789910559c79ba594
Autor:
David Cano-Terriza, Adrián Beato-Benítez, Leira Fernández-Bastit, Joaquim Segalés, Júlia Vergara-Alert, Eva Martínez-Nevado, Andrea Carretero, Dietmar Crailsheim, Pilar Soriano, Javier Planas, Mario Torro, Ignacio García-Bocanegra
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 6, Pp 1253-1257 (2024)
We conducted a serologic and molecular study to assess exposure of captive nonhuman primates (NHPs) to SARS-CoV-2 in Spain during the 2020–2023 COVID-19 pandemic. We found limited exposure of NHPs to SARS-CoV-2. Biosafety measures must be strictly
Externí odkaz:
https://doaj.org/article/b48d9a3bba414a758c6309f075797e86
Autor:
Laura del Puerto-Nevado, María J. Fernández-Aceñero, Arancha Cebrián, Yuliia Fatych, Luis I. Díez-Valladares, Elia Pérez-Aguirre, Sofía de la Serna, Alejandra García-Botella, Javier Martínez-Useros, Jesús García-Foncillas, Pedro A. Mateos-Gómez
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDNA polymerase theta (POLQ) is a translesion synthesis polymerase essential for the repair of double strand breaks by the error-prone TMEJ (Theta Mediated End Joining) pathway. Although POLQ participates in maintaining genome stability, sev
Externí odkaz:
https://doaj.org/article/0b3c55f609be443fb31ae697dcffea83