Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation

Autor: Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind, Henrik Franzyk, Claes Dahlgren, Martina Sundqvist, Huamei Forsman

Publikováno v: Viklund, M, Fredriksson, J, Holdfeldt, A, Lind, S, Franzyk, H, Dahlgren, C, Sundqvist, M & Forsman, H 2022, ' Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation. ', Journal of Immunology, vol. 208, no. 7, pp. 1632-1641 . https://doi.org/10.4049/jimmunol.2101039

Highly pathogenic Staphylococcus aureus strains produce phenol-soluble modulins (PSMs), which are N-formylated peptides. Nanomolar concentrations of PSMα2 are recognized by formyl peptide receptor 2 (FPR2), but unlike the prototypic FPR2 agonist WKY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc31dfc803cc9843074697bd5c669423
https://curis.ku.dk/portal/da/publications/structural-determinants-in-the-staphylococcus-aureusderived-phenolsoluble-modulin-2-peptide-required-for-neutrophil-formyl-peptide-receptor-activation(40b1ceb3-fe3e-496d-8873-63dcb8601a41).html

Sleep modulates hematopoiesis and protects against atherosclerosis

Autor: Peter Libby, Vanessa Frodermann, Friedrich Felix Hoyer, Christoph J. Binder, Christopher T. Chan, Annemijn F. Gregory, Yoshiko Iwamoto, Anne Vassalli, Cameron S. McAlpine, Matthias Nahrendorf, Atsushi Anzai, Filip K. Swirski, Thomas E. Scammell, Shun He, Florian Kahles, Wolfram C. Poller, Ashley M. Fenn, Mehdi Tafti, John E. Mindur, Colin Valet, Sara Rattik, Lennard Halle, M. Kiss

Publikováno v: Nature
Nature, vol. 566, no. 7744, pp. 383-387

Sleep is integral to life 1 . Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease 2 , we know little about the cellular and molecular mechanisms by which sleep maintains ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce735b02272ecc0fdf0ecec71fd5eaa
http://europepmc.org/articles/PMC6442744

Longitudinal characterisation of haematological and biochemical parameters in cancer patients prior to and during COVID-19 reveals features associated with outcome

Autor: P. Huddar, A. Angelakas, Michelle Harrison, G. Brearton, Umair T Khan, S. Khan, T. Robinson, C. Wilson, Oskar Wysocki, K. Banfill, Alec Maynard, C. Hague, Daniel H. Palmer, Mark Baxter, Tim Cooksley, Anne Thomas, J. Tweedy, Carlo Palmieri, André Freitas, C. Dive, H. Boyce, Simon G. Williams, C. Zhou, Anne C Armstrong, Alexander J. Stockdale, T. Aung, Z. Hudson, Ellen Copson, L. Eastlake, M. Rowe, E. Dickens, F. Gomes, T. Bhogal, Jamie M Weaver, L. Horsley, A. Tivey, Rebecca Lee, Rohan Shotton, H. McKenzie, R. Sheehan

Publikováno v: Lee, R J, Wysocki, O, Bhogal, T, Shotton, R, Tivey, A, Angelakas, A, Aung, T, Banfill, K, Baxter, M, Boyce, H, Brearton, G, Copson, E, Dickens, E, Eastlake, L, Gomes, F, Hague, C, Harrison, M, Horsley, L, Huddar, P, Hudson, Z, Khan, S, Khan, U T, Maynard, A, Mckenzie, H, Palmer, D, Robinson, T, Rowe, M, Thomas, A, Tweedy, J, Sheehan, R, Stockdale, A, Weaver, J, Williams, S, Wilson, C, Zhou, C, Dive, C, Cooksley, T, Palmieri, C, Freitas, A & Armstrong, C A 2021, ' Longitudinal characterisation of haematological and biochemical parameters in cancer patients prior to and during COVID-19 reveals features associated with outcome ', ESMO Open, vol. 6, no. 1, 100005, pp. 1-12 . https://doi.org/10.1016/j.esmoop.2020.100005
ESMO Open
Lee, RJ, Wysocki, O, Bhogal, T, Shotton, R, Tivey, A, Angelakas, A, Aung, T, Banfill, K, Baxter, M, Boyce, H, Brearton, G, Copson, E, Dickens, E, Eastlake, L, dummy-AUTHOR_name & Armstrong, AC 2020, ' Longitudinal characterisation of haematological and biochemical parameters in cancer patients prior to and during COVID-19 reveals features associated with outcome. ', ESMO Open, vol. 6, no. 1, 100005, pp. 100005 . https://doi.org/10.1016/j.esmoop.2020.100005
ESMO OPEN

Background Cancer patients are at increased risk of death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Cancer and its treatment affect many haematological and biochemical parameters, therefore we analysed these prior to and duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2613c6b208c2bf50360cf1e4113c5884

Progressive Control of Streptococcus agalactiae-Induced Innate Inflammatory Response Is Associated with Time Course Expression of MicroRNA-223 by Neutrophils

Autor: Georges Casimir, Maud Deny, Marta Romano, Olivier Denis, Mustapha Chamekh

Publikováno v: Infection and immunity, 88 (12
Infect Immun

Group B streptococcus (GBS) is a human-pathogenic bacterium inducing a strong inflammatory response that may be detrimental for host tissues if not finely regulated. The inflammatory response can be modulated by different molecular mechanisms, among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497d47715aae5e5f3127dfeabce4eb56
https://doi.org/10.1128/iai.00563-20

Proteome Analysis of Human Neutrophil Granulocytes From Patients With Monogenic Disease Using Data-independent Acquisition

Autor: Grabowski, Piotr, Hesse, Sebastian, Hollizeck, Sebastian, Rohlfs, Meino, Behrends, Uta, Sherkat, Roya, Tamary, Hannah, Ünal, Ekrem, Somech, Raz, Patıroğlu, Türkan, Canzar, Stefan, van der Werff Ten Bosch, Jutte, Klein, Christoph, Rappsilber, Juri

Publikováno v: Grabowski, P, Hesse, S, Hollizeck, S, Rohlfs, M, Behrends, U, Sherkat, R, Tamary, H, Ünal, E, Somech, R, Patıroğlu, T, Canzar, S, van der Werff Ten Bosch, J, Klein, C & Rappsilber, J 2019, ' Proteome analysis of human neutrophil granulocytes from patients with monogenic disease using data-independent acquisition ', Molecular and Cellular Proteomics, vol. 18, no. 4, pp. 760-772 . https://doi.org/10.1074/mcp.RA118.001141

Neutrophil granulocytes are critical mediators of innate immunity and tissue regeneration. Rare diseases of neutrophil granulocytes may affect their differentiation and/or functions. However, there are very few validated diagnostic tests assessing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fd10913de9269e45499d19855b3d23f0
https://doi.org/10.1074/mcp.ra118.001141