Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom: Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection

Autor: Tanya Golubchik, Anthony C. Gordon, Rutger J. Ploeg, Ullrich Leuscher, Wendy Slack, Pat Tsang, Manu Shankar-Hari, David K. Menon, Paul R Mouncey, Sarah Williams, Lise J Estcourt, Sheba Ziyenge, Farah Al-Beidh, Heli Harvala, Nick A Ciccone, Peter Simmonds, David J. Roberts, Jeremy Ratcliff, Kathryn M Rowan, Abigail Lamikanra, Jennifer Rynne, Amy Evans, Dung Nguyen, Aislinn Jennings, Matthew Fish, Emma Laing, David Bonsall, Marta S Oliveira

Publikováno v: 2021, ' Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom : Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection ', The Journal of Infectious Diseases, vol. 224, no. 4, pp. 595-605 . https://doi.org/10.1093/infdis/jiab283

BackgroundConvalescent plasma containing neutralizing antibody to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is under investigation for coronavirus disease 2019 (COVID-19) treatment. We report diverse virological characteristics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935a99113299cb16abdecddfb35876e
https://doi.org/10.1093/infdis/jiab283

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Autor: Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Manry, Jérémy, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina, Bizien, Lucy, Parra-Martínez, Alba, Yang, Rui, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Cognasse, Fabrice, Troya, Jesus, Trouillet-Assant, Sophie, Belot, Alexandre, Saker, Kahina, Garçon, Pierre, Rivière, Jacques G., Lagier, Jean-Christophe, Gentile, Stéphanie, Rosen, Lindsey B., Shaw, Elana, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis, Sene, Damien, Stepanian, Alain, Megarbane, Bruno, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R., Franco, José Luis, Anaya, Juan-Manuel, Solé-Violán, Jordi, Imberti, Luisa, Biondi, Andrea, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M., Zhang, Yu, Snow, Andrew L., Holland, Steven M., Biggs, Catherine M., Moncada-Vélez, Marcela, Arias, Andrés Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Coulibaly, Boubacar, Anglicheau, Dany, Planas, Anna M., Haerynck, Filomeen, Duvlis, Sotirija, Nussbaum, Robert L., Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A., El Bakkouri, Jalila, Ramirez-Santana, Carolina, Paul, Stéphane, Pan-Hammarström, Qiang, Hammarström, Lennart, Dupont, Annabelle, Kurolap, Alina, Metz, Christine N., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A., Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G., Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y., Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C., Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H., Kennelly, Sean P., Bourke, Nollaig M., Halwani, Rabih, Sharif-Askari, Narjes Saheb, Dorgham, Karim, Sallette, Jérome, Mehlal Sedkaoui, Souad, AlKhater, Suzan, Rigo-Bonnin, Raúl, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C., Ostrowski, Sisse Rye, Condino-Neto, Antonio, Prando, Carolina, Bondarenko, Anastasiia, Spaan, András N., Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P., Mane, Shrikant, Anderson, Mark S., Boisson, Bertrand, Béziat, Vivien, Zhang, Shen-Ying, Andreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Pärt, Mogensen, Trine H., Rowen, Lee, Mond, James, Debette, Stéphanie, de Lamballerie, Xavier, Duval, Xavier, Mentré, France, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier, Vasse, Marc, Gregersen, Peter K., Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D., Su, Helen C., Kisand, Kai, Okada, Satoshi, Puel, Anne, Jouanguy, Emmanuelle, Rice, Charles M., Tiberghien, Pierre, Zhang, Qian, Cobat, Aurélie, Abel, Laurent, Casanova, Jean-Laurent, Bigio, Benedetta, de la Chapelle, Aliénor, Chen, Jie, Chrabieh, Maya, Liu, Dana, Nemirowskaya, Yelena, Cruz, Inés Marín, Materna, Marie, Pelet, Sophie, Seeleuthner, Yoann, Thibault, Chloé, Liu, Zhiyong, Abad, Jorge, Accordino, Giulia, Achille, Cristian, Aguilera-Albesa, Sergio, Aguiló-Cucurull, Aina, Özkan, Esra Akyüz, Darazam, Ilad Alavi, Roblero Albisures, Jonathan Antonio, Aldave, Juan C, Ramos, Miquel Alfonso, Khan, Taj Ali, Aliberti, Anna, Nadji, Seyed Alireza, Alkan, Gulsum, Alkhater, Suzan A., Allardet-Servent, Jerome, Allende, Luis M, Alonso-Arias, Rebeca, Alshahrani, Mohammed S, Alsina, Laia, Alyanakian, Marie-Alexandra, Borrero, Blanca Amador, Amoura, Zahir, Antolí, Arnau, Aubart, Mélodie, Auguet, Teresa, Avramenko, Iryna, Aytekin, Gökhan, Azot, Axelle, Bahram, Seiamak, Bajolle, Fanny, Baldanti, Fausto, Baldolli, Aurélie, Ballester, Maite, Feldman, Hagit Baris, Barrou, Benoit, Barzagh, Federica, Basso, Sabrina, Bayhan, Gulsum Iclal, Bezrodnik, Liliana, Bilbao, Agurtzane, Blanchard-Rohner, Geraldine, Blanco, Ignacio, Blandinières, Adeline, Blázquez-Gamero, Daniel, Bleibtreu, Alexandre, Bloomfield, Marketa, Bolivar-Prados, Mireia, Borghesi, Alessandro, Borie, Raphael, Botdhlo-Nevers, Elisabeth, Bousfiha, Ahmed A, Bousquet, Aurore, Boutolleau, David, Bouvattier, Claire, Bravais, Juliette, Briones, M. 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Publikováno v: Science Immunology
Science Immunology, 2021, 6 (62), pp.eabl4340. ⟨10.1126/sciimmunol.abl4340⟩
ISI atlas of science. Immunology 6 (2021). doi:10.1126/sciimmunol.abl4340
info:cnr-pdr/source/autori:Bastard P.; Gervais A.; Le Voyer T.; Rosain J.; Philippot Q.; Manry J.; Michailidis E.; Hoffmann H.-H.; Eto S.; Garcia-Prat M.; Bizien L.; Parra-Martinez A.; Yang R.; Haljasmagi L.; Migaud M.; Sarekannu K.; Maslovskaja J.; Prost N.D.; Tandjaoui-Lambiotte Y.; Luyt C.-E.; Amador-Borrero B.; Gaudet A.; Poissy J.; Morel P.; Richard P.; Cognasse F.; Troya J.; Trouillet-Assant S.; Belot A.; Saker K.; Garcon P.; Riviere J.G.; Lagier J.-C.; Gentile S.; Rosen L.B.; Shaw E.; Morio T.; Tanaka J.; Dalmau D.; Tharaux P.-L.; Sene D.; Stepanian A.; Megarbane B.; Triantafyllia V.; Fekkar A.; Heath J.R.; Franco J.L.; Anaya J.-M.; Sole-Violan J.; Imberti L.; Biondi A.; Bonfanti P.; Castagnoli R.; Delmonte O.M.; Zhang Y.; Snow A.L.; Holland S.M.; Biggs C.M.; Moncada-Velez M.; Arias A.A.; Lorenzo L.; Boucherit S.; Coulibaly B.; Anglicheau D.; Planas A.M.; Haerynck F.; Duvlis S.; Nussbaum R.L.; Ozcelik T.; Keles S.; Bousfiha A.A.; Bakkouri J.E.; Ramirez-Santana C.; Paul S.; Pan-Hammarstrom Q.; Hammarstrom L.; Dupont A.; Kurolap A.; Metz C.N.; Aiuti A.; Casari G.; Lampasona V.; Ciceri F.; Barreiros L.A.; Dominguez-Garrido E.; Vidigal M.; Zatz M.; Beek D.V.D.; Sahanic S.; Tancevski I.; Stepanovskyy Y.; Boyarchuk O.; Nukui Y.; Tsumura M.; Vidaur L.; Tangye S.G.; Burrel S.; Duffy D.; Quintana-Murci L.; Klocperk A.; Kann N.Y.; Shcherbina A.; Lau Y.-L.; Leung D.; Coulongeat M.; Marlet J.; Koning R.; Reyes L.F.; Chauvineau-Grenier A.; Venet F.; Monneret G.; Nussenzweig M.C.; Arrestier R.; Boudhabhay I.; Baris-Feldman H.; Hagin D.; Wauters J.; Meyts I.; Dyer A.H.; Kennelly S.P.; Bourke N.M.; Halwani R.; Sharif-Askari N.S.; Dorgham K.; Sallette J.; Sedkaoui S.M.; AlKhater S.; Rigo-Bonnin R.; Morandeira F.; Roussel L.; Vinh D.C.; Ostrowski S.R.; Condino-Neto A.; Prando C.; Bondarenko A.; Spaan A.N.; Gilardin L.; Fellay J.; Lyonnet S.; Bilguvar K.; Lifton R.P.; Mane S.; Anderson M.S.; Boisson B.; Beziat V.; Zhang S.-Y.; Andreakos E.; Hermine O.; Pujol A.; Peterson P.; Mogensen T.H.; Rowen L.; Mond J.; Debette S.; Lamballerie X.D.; Duval X.; Mentre F.; Zins M.; Soler-Palacin P.; Colobran R.; Gorochov G.; Solanich X.; Susen S.; Martinez-Picado J.; Raoult D.; Vasse M.; Gregersen P.K.; Piemonti L.; Rodriguez-Gallego C.; Notarangelo L.D.; Su H.C.; Kisand K.; Okada S.; Puel A.; Jouanguy E.; Rice C.M.; Tiberghien P.; Zhang Q.; Cobat A.; Abel L.; Casanova J.-L./titolo:Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths/doi:10.1126%2Fsciimmunol.abl4340/rivista:ISI atlas of science. Immunology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Science Immunology, 2021, 6 (62), ⟨10.1126/sciimmunol.abl4340⟩
Science immunology, 6(62):eabl4340. American Association for the Advancement of Science
Dipòsit Digital de la UB
Universidad de Barcelona
Science Immunology, American Association for the Advancement of Science, 2021, 6 (62), ⟨10.1126/sciimmunol.abl4340⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Bastard, P, Gervais, A, Le Voyer, T, Rosain, J, Philippot, Q, Manry, J, Michailidis, E, Hoffmann, H H, Eto, S, Garcia-Prat, M, Bizien, L, Parra-Martínez, A, Yang, R, Haljasmägi, L, Migaud, M, Särekannu, K, Maslovskaja, J, Prost, N D, Tandjaoui-Lambiotte, Y, Luyt, C E, Amador-Borrero, B, Gaudet, A, Poissy, J, Morel, P, Richard, P, Cognasse, F, Troya, J, Trouillet-Assant, S, Belot, A, Saker, K, Garçon, P, Rivière, J G, Lagier, J C, Gentile, S, Rosen, L B, Shaw, E, Morio, T, Tanaka, J, Dalmau, D, Tharaux, P L, Sene, D, Stepanian, A, Megarbane, B, Triantafyllia, V, Fekkar, A, Heath, J R, Franco, J L, Anaya, J M, Mogensen, T H, Casanova, J L, The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James’s Hospital SARS CoV2 Interest group, French COVID Cohort Study Group & Imagine COVID Group 2021, ' Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths ', Science Immunology, vol. 6, no. 62, 4340 . https://doi.org/10.1126/sciimmunol.abl4340
Science immunology, vol. 6, no. 62, pp. eabl4340
French COVID Cohort Study Group, NIAID Immune Response to COVID Group, Danish CHGE, COVID Human Genetic Effort, HGID Lab, COVID-STORM Clinicians, NH-COVAIR Study Group, The Danish Blood Donor Study (DBDS), Imagine COVID-Group, The Milieu Intérieur Consortium, Amsterdam UMC Covid-19 Biobank, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, CoV-Contact Cohort, St James's Hospital, SARS CoV2 Interest group & COVID Clinicians 2021, ' Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths ', Science immunology, vol. 6, no. 62, eabl4340 . https://doi.org/10.1126/sciimmunol.abl4340
SCIENCE IMMUNOLOGY
COVID Human Genetic Effort, Imagine COVID-Group, Danish CHGE, CONSTANCES cohort, Etablissement du Sang study group, St James's Hospital, SARS CoV2 Interest group, 3C-Dijon Study, COVID Clinicians, CoV-Contact Cohort, NIAID Immune Response to COVID Group, Cerba HealthCare, French COVID Cohort Study Group, HGID Lab, COVID-STORM Clinicians, NH-COVAIR Study Group, The Danish Blood Donor Study (DBDS), The Milieu Intérieur Consortium & Amsterdam UMC Covid-19 Biobank 2021, ' Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths ', Science immunology, vol. 6, no. 62, eabl4340 . https://doi.org/10.1126/sciimmunol.abl4340, https://doi.org/10.1126/sciimmunol.abl4340
Digital.CSIC. Repositorio Institucional del CSIC
instname

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9782ed7fd520b02e3e125e6fda82e43d
https://hal.science/hal-03358792/file/BPH_SI_2021_Bastard.pdf

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

Autor: Ella Reed, Clemens Gutmann, Bhawana Singh, Torsten Tonn, Sean A. Burnap, Salvatore Napoli, Ajay M. Shah, Jonathan D. Edgeworth, Manu Shankar-Hari, Konstantinos Theofilatos, Kaloyan Takov, Lukas E Schmidt, Kevin O'Gallagher, Katie J. Doores, Mauro Giacca, Rafael Fernandez-Leiro, Konstantina Dimitrakopoulou, Barnaby Sanderson, Mansoor Saqi, Mark J. W. McPhail, Adrian Hayday, Hashim Ali, Salma F Mujib, Georg Auzinger, Matthew Fish, Romy Kronstein-Wiedemann, Manuel Mayr, Francesca Trovato, Marieke Rienks, Stefan R. Bornstein, Christian Cassel, Umar Niazi, Adam Nabeebaccus, Silke Braun, Blair Merrick, Maria Hasman, Xiaoke Yin

Publikováno v: Gutmann, C, Takov, K, Burnap, S A, Singh, B, Ali, H, Theofilatos, K, Reed, E, Hasman, M, Nabeebaccus, A, Fish, M, McPhail, M J, O'Gallagher, K, Schmidt, L E, Cassel, C, Rienks, M, Yin, X, Auzinger, G, Napoli, S, Mujib, S F, Trovato, F, Sanderson, B, Merrick, B, Niazi, U, Saqi, M, Dimitrakopoulou, K, Fernández-Leiro, R, Braun, S, Kronstein-Wiedemann, R, Doores, K J, Edgeworth, J D, Shah, A M, Bornstein, S R, Tonn, T, Hayday, A C, Giacca, M, Shankar-Hari, M & Mayr, M 2021, ' SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care ', Nature Communications, vol. 12, no. 1, pp. 3406 . https://doi.org/10.1038/s41467-021-23494-1
Nature Communications
Gutmann, C, Takov, K, Burnap, S A, Singh, B, Ali, H, Theofilatos, K, Reed, E, Hasman, M, Nabeebaccus, A, Fish, M, McPhail, M J, O'Gallagher, K, Schmidt, L E, Cassel, C, Rienks, M, Yin, X, Auzinger, G, Napoli, S, Mujib, S F, Trovato, F, Sanderson, B, Merrick, B, Niazi, U, Saqi, M, Dimitrakopoulou, K, Fernández-Leiro, R, Braun, S, Kronstein-Wiedemann, R, Doores, K J, Edgeworth, J D, Shah, A M, Bornstein, S R, Tonn, T, Hayday, A C, Giacca, M, Shankar-Hari, M & Mayr, M 2021, ' SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care ', Nature Communications, vol. 12, no. 1, 3406 . https://doi.org/10.1038/s41467-021-23494-1
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples (n = 474) from hospitalized COVID-19 patients (n = 123), non-COVID-19 ICU sepsis patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b54981bd87b0451c4c66e6cc9dea4d
https://www.pure.ed.ac.uk/ws/files/263687109/s41467_021_23494_1.pdf

Novel SARS-CoV-2 variants: the pandemics within the pandemic

Autor: Boehm, Erik, Kronig, Ilona, Neher, Richard A, Eckerle, Isabella Anne, Vetter, Pauline, Kaiser, Laurent

Publikováno v: Clinical Microbiology and Infection, Vol. 27, No 8 (2021) pp. 1109-1117

Many new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been termed variants of concern/interest (VOC/I) because of the greater risk they pose due to possible enhanced transmissibility and/or severity, immune escape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::efe3186c51fd4a01109e1a8856be5d78
https://archive-ouverte.unige.ch/unige:158221

Safety, tolerability and efficacy of intradermal rabies immunization with DebioJect™

Autor: Julie Liberman, Pierre-Alexandre Bart, Laurent-Dominique Piveteau, Paul Vescovo, Reto Zanoni, Nirinarilala Ramaniraka, Astrid Cachemaille, Giuseppe Pantaleo, Nils Rettby, Karen Hart

Publikováno v: Vescovo, Paul; Rettby, Nils; Ramaniraka, Nirinarilala; Liberman, Julie; Hart, Karen; Cachemaille, Astrid; Piveteau, Laurent-Dominique; Zanoni, Reto Giacomo; Bart, Pierre-Alexandre; Pantaleo, Giuseppe (2017). Safety, tolerability and efficacy of intradermal rabies immunization with DebioJect™. Vaccine, 35(14), pp. 1782-1788. Elsevier 10.1016/j.vaccine.2016.09.069
Vaccine, vol. 35, no. 14, pp. 1782-1788

In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6df476e92d4c57a335f25b3a8519b3f
https://doi.org/10.1016/j.vaccine.2016.09.069