Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Neurotransmitter Receptor Signaling"'
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232748 (2020)
PLoS ONE
Riedel, C S, Georg, B, Fahrenkrug, J & Hannibal, J 2020, ' Altered light induced EGR1 expression in the SCN of PACAP deficient mice ', PLoS ONE, vol. 15, no. 5, e0232748 . https://doi.org/10.1371/journal.pone.0232748
PLoS ONE
Riedel, C S, Georg, B, Fahrenkrug, J & Hannibal, J 2020, ' Altered light induced EGR1 expression in the SCN of PACAP deficient mice ', PLoS ONE, vol. 15, no. 5, e0232748 . https://doi.org/10.1371/journal.pone.0232748
The brain's biological clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus and generates circadian rhythms in physiology and behavior. The circadian clock needs daily adjustment by light to stay synchronized (entrained) with the
Autor:
Brian D. McCabe, Lewis M. Sherer, Jessica L. Williams, R. Steven Stowers, Lucy A. Sirrs, Edmond D. Brewer, Elizabeth Catudio Garrett, Harold K. Shearin, Hannah R. Morgan, Sarah J. Certel
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 2, p e1008609 (2020)
PLoS Genetics, Vol 16, Iss 2, p e1008609 (2020)
Neuromodulators such as monoamines are often expressed in neurons that also release at least one fast-acting neurotransmitter. The release of a combination of transmitters provides both “classical” and “modulatory” signals that could produce
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0216467 (2019)
PLoS ONE, Vol 14, Iss 5, p e0216467 (2019)
Abnormal red blood cell (RBC) adhesion to endothelial αvβ3 plays a crucial role in triggering vaso-occlusive episodes in sickle cell disease (SCD). It is known that epinephrine, a β-adrenergic receptor (β-AR) stimulator, increases the RBC surface
Autor:
Huijie Feng, Casandra L Larrivee, Jeff R. Leipprandt, Huirong Xie, Elena Y. Demireva, Richard R. Neubig
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258912 (2021)
PLoS ONE, Vol 14, Iss 1, p e0211066 (2019)
PLoS ONE, Vol 16, Iss 10, p e0258912 (2021)
PLoS ONE, Vol 14, Iss 1, p e0211066 (2019)
BackgroundInfants and children with dominantde novomutations inGNAO1exhibit movement disorders, epilepsy, or both. Children with loss-of-function (LOF) mutations exhibit Epileptiform Encephalopathy 17 (EIEE17). Gain-of-function (GOF) mutations or tho
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0220434 (2019)
PLoS ONE, Vol 14, Iss 8, p e0220434 (2019)
Human fumarylacetoacetate hydrolase (FAH) domain containing protein 1 (FAHD1) is a mitochondrial oxalocatate decarboxylase, the first of its kind identified in eukaryotes. The physiological role of FAHD1 in other eukaryotes is still poorly understood
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0185253 (2017)
PLoS ONE, Vol 12, Iss 9, p e0185253 (2017)
In this study, we performed a comprehensive evaluation of the proteomic profile of the pituitary gland of the Huoyan goose during the laying period compared to the pre-laying period using an iTRAQ-based approach. Protein samples were prepared from pi
Publikováno v:
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 12, Iss 2, p e0172368 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 12, Iss 2, p e0172368 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Synaptic activity is regulated and limited by blood flow, which is controlled by blood vessel dilation and contraction. Traditionally, the study of neurovascular coupling has mainly focused on energy consumption and oxygen delivery. However, the mech
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0160585 (2016)
PLoS ONE, Vol 11, Iss 8, p e0160585 (2016)
Prenatal cocaine exposure causes profound changes in neurobehavior as well as synaptic function and structure with compromised glutamatergic transmission. Since synaptic health and glutamatergic activity are tightly regulated by brain-derived neurotr
Publikováno v:
Padmakumar, M, Brain, K, Young, J & Manchanda, R 2018, ' A four-component model of the action potential in mouse detrusor smooth muscle cell ', PLoS One, vol. 13, no. 1, e0190016 . https://doi.org/10.1371/journal.pone.0190016
PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0190016 (2018)
PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0190016 (2018)
Background and hypothesis - Detrusor smooth muscle cells (DSMCs) of the urinary bladder are electrically connected to one another via gap junctions and form a three dimensional syncytium. DSMCs exhibit spontaneous electrical activity, including passi
Autor:
Debolina Ghosh, Ethan Foscue, Jodi Gresack, Paul Greengard, Jonathan A. Ellman, Marcie A. Glicksman, George M. Anderson, Manavi Chatterjee, Yang Zhang, Angus C. Nairn, Jonathan Brouillette, Gregory D. Cuny, Tyler D. Baguley, Jean Kanyo, Jian Xu, Chimezie Ononenyi, TuKiet T. Lam, Lutz Tautz, Kathleen Seyb, Paul J. Lombroso, Pradeep Kurup
Publikováno v:
PLoS Biology, Vol 12, Iss 8, p e1001923 (2014)
PLoS Biology
PLoS Biology
This study identifies an unusual sulfur-based chemical as a novel and specific inhibitor of the tyrosine phosphatase STEP and shows that it can improve the cognitive function of a mouse model of Alzheimer's disease.
STEP (STriatal-Enriched prote
STEP (STriatal-Enriched prote