Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Neuroscience: Neurobiology of Disease"'
Publikováno v:
PLoS ONE
Background Parkinson's disease (PD) is a neurodegenerative pathology whose molecular etiopathogenesis is not known. Novel contributions have come from familial forms of PD caused by alterations in genes with apparently unrelated physiological functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4c6ea0257c74da7727426d5aebb1ff8
https://pubmed.ncbi.nlm.nih.gov/18382667
https://pubmed.ncbi.nlm.nih.gov/18382667
Autor:
Atul, Maheshwari, Abraham, Akbar, Mai, Wang, Rachel L, Marks, Katherine, Yu, Suhyeorn, Park, Brett L, Foster, Jeffrey L, Noebels
In two monogenic models of absence epilepsy, interictal beta/gamma power is augmented in homozygous stargazer (stg/stg) but not homozygous tottering (tg/tg) mice. There are distinct gene-linked patterns of aberrant phase-amplitude coupling in the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bb950e0472c06382a8d747b4b67d1557
https://europepmc.org/articles/PMC5709336/
https://europepmc.org/articles/PMC5709336/
Autor:
Héctor, Gaitán-Peñas, Pirjo M, Apaja, Tanit, Arnedo, Aida, Castellanos, Xabier, Elorza-Vidal, David, Soto, Xavier, Gasull, Gergely L, Lukacs, Raúl, Estévez
Publikováno v:
The Journal of physiology. 595(22)
Characterisation of most mutations found in CLCN2 in patients with CC2L leukodystrophy show that they cause a reduction in function of the chloride channel ClC-2. GlialCAM, a regulatory subunit of ClC-2 in glial cells and involved in the leukodystrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd342850b4d213c956eb20ee1fe527dd
https://pubmed.ncbi.nlm.nih.gov/28905383
https://pubmed.ncbi.nlm.nih.gov/28905383
Autor:
Nikita, Gamper
Publikováno v:
The Journal of physiology. 595(11)
Chloroquine (CQ) stimulates itch nerves and causes intense scratching in mice by activating the G‐protein coupled receptor (GPCR) MrgprA3; it is not known how stimulation of MrgprA3 (or other GPCRs) leads to activation of the itch nerve terminals i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5365e20fa0988853a458eb093af3ea3
https://pubmed.ncbi.nlm.nih.gov/28217875
https://pubmed.ncbi.nlm.nih.gov/28217875
Autor:
Yvonne Nyavor, Onesmo B. Balemba
Publikováno v:
The Journal of physiology. 595(5)
A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota dysbiosis, which occurs in response to HFD, contributes to endotoxaemia. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b585f07bed40bab06d64df55ec35960e
https://pubmed.ncbi.nlm.nih.gov/28000223
https://pubmed.ncbi.nlm.nih.gov/28000223
Autor:
Totola, Leonardo T., Takakura, Ana C., Oliveira, José Antonio C., Garcia‐Cairasco, Norberto, Moreira, Thiago S.
It is recognized that seizures commonly cause apnoea and oxygen desaturation, but there is still a lack in the literature about the respiratory impairments observed ictally and in the post‐ictal period.Respiratory disorders may involve changes in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c7700e364022edfadd3830fcb83bb01
https://europepmc.org/articles/PMC5285626/
https://europepmc.org/articles/PMC5285626/
Spinocerebellar ataxia type 6 (SCA6) is a midlife‐onset neurodegenerative disease caused by a CACNA1A mutation; CACNA1A is also implicated in cerebellar development.We have previously shown that when disease symptoms are present in midlife in SCA68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::da337e7194026beafdc6c77a28cd8275
https://europepmc.org/articles/PMC5285638/
https://europepmc.org/articles/PMC5285638/
Cognitive performance is impaired by hypoxia despite global cerebral oxygen delivery and metabolism being maintained. Using arterial spin labelled (ASL) magnetic resonance imaging, this is the first study to show regional reductions in cerebral blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af0366e8e28c7d83851c549380e714b1
https://europepmc.org/articles/PMC5285718/
https://europepmc.org/articles/PMC5285718/
Autor:
Esther, Udina, Charles T, Putman, Luke R, Harris, Neil, Tyreman, Victoria E, Cook, Tessa, Gordon
Publikováno v:
The Journal of physiology. 595(5)
Smn +/− transgenic mouse is a model of the mildest form of spinal muscular atrophy.Although there is a loss of spinal motoneurons in 11‐month‐old animals, muscular force is maintained.This maintained muscular force is mediated by reinnervation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab0f086ccdc093d0d2bc83965901616e
https://pubmed.ncbi.nlm.nih.gov/27891608
https://pubmed.ncbi.nlm.nih.gov/27891608
Impaired uptake of glutamate builds up the extracellular level of this excitatory transmitter to trigger rhythmic neuronal bursting and delayed cell death in the brainstem motor nucleus hypoglossus. This process is the expression of the excitotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5d78dea4b2c457b317038aa03542c0c3
https://europepmc.org/articles/PMC5108918/
https://europepmc.org/articles/PMC5108918/