DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70

Publikováno v: PLoS ONE

Background Parkinson's disease (PD) is a neurodegenerative pathology whose molecular etiopathogenesis is not known. Novel contributions have come from familial forms of PD caused by alterations in genes with apparently unrelated physiological functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4c6ea0257c74da7727426d5aebb1ff8
https://pubmed.ncbi.nlm.nih.gov/18382667

Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography

Autor: Naoyuki Tanimoto, Andreas Wenzel, Charlotte E. Remé, Mathias W. Seeliger, Rod Bremner, M. Dominik Fischer, Regine Muehlfriedel, Serge A. van de Pavert, Gesine Huber, Jan Wijnholds, Christian Grimm, Marek Pacal, Susanne C. Beck, E. Fahl

Publikováno v: PLoS ONE
PLoS ONE, Vol 4, Iss 10, p e7507 (2009)
PLoS ONE, 4(10), 1-7. Public Library of Science
Fischer, M D, Huber, G, Beck, S C, Tanimoto, N, Muehlfriedel, R, Fahl, E, Grimm, C, Wenzel, A, Reme, C E, van de Pavert, S A, Wijnholds, J, Pacal, M, Bremner, R & Seeliger, M W 2009, ' Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography ', PLoS ONE, vol. 4, no. 10, pp. 1-7 . https://doi.org/10.1371/journal.pone.0007507
PLoS One, 4. Public Library of Science

BackgroundOptical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration.Methodology/principal findingsWe a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75811cdb0ad1ad50c7f5be3c6e587d6e
https://doi.org/10.1371/journal.pone.0007507

A Yeast Model of FUS/TLS-Dependent Cytotoxicity

Autor: Sun, Zhihui, Diaz, Zamia, Fang, Xiaodong, Hart, Michael P., Chesi, Alessandra, Shorter, James, Gitler, Aaron D.

Publikováno v: PLoS Biology

A combination of yeast genetics and protein biochemistry define how the fused in sarcoma (FUS) protein might contribute to Lou Gehrig's disease.
TDP-43 and FUS are RNA-binding proteins that form cytoplasmic inclusions in some forms of amyotrophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2feca885825c4d35f40fe6f976ebcf5b
http://europepmc.org/articles/PMC3082519

Apolipoprotein E: Isoform Specific Differences in Tertiary Structure and Interaction with Amyloid-β in Human Alzheimer Brain

Autor: Brian J. Bacskai, Tadafumi Hashimoto, Anete Rozkalne, Christine A. F. von Armin, Mathew Mielke, Bradley T. Hyman, Tara L. Spires-Jones, Tammy T. Hshieh, Phillip B. Jones, Kenneth W. Adams

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14586 (2011)
Jones, P B, Adams, K W, Rozkalne, A, Spires-Jones, T L, Hshieh, T T, Hashimoto, T, von Armin, C A F, Mielke, M, Bacskai, B J & Hyman, B T 2011, ' Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain ', PLoS ONE, vol. 6, no. 1, pp. e14586 . https://doi.org/10.1371/journal.pone.0014586

We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c923337a7dcfd41ac229f0ab114a19ce
http://europepmc.org/articles/PMC3031506

Misrepresentation of Neuroscience Data Might Give Rise to Misleading Conclusions in the Media: The Case of Attention Deficit Hyperactivity Disorder

Autor: Erwan Bezard, François Gonon, Thomas Boraud

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2011, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014618. ⟨10.1371/journal.pone.0014618⟩
PLoS ONE, Vol 6, Iss 1, p e14618 (2011)

BackgroundThere is often a huge gap between neurobiological facts and firm conclusions stated by the media. Data misrepresentation in the conclusions and summaries of neuroscience articles might contribute to this gap.Methodology/principal findingsUs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d8bc2cd62e1ccd866cb60527371f85
https://hal.archives-ouvertes.fr/hal-01160423