Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Neuroregulation and Motility"'
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G924-G933
The extracellular signal that triggers activation of rho-associated kinase (RhoA/ROCK), the major molecular determinant of basal internal anal sphincter (IAS) smooth muscle tone, is not known. Using human IAS tissues, we identified the presence of th
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G863-G873
Chronic high-fat feeding is associated with functional dyspepsia and delayed gastric emptying. We hypothesize that high-fat feeding upregulates gastric neuronal nitric oxide synthase (nNOS) expression, resulting in delayed gastric emptying. We propos
Autor:
Mehboob Ali, Satish Rattan
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G605-G612
Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs. r
Autor:
Toru Kono, Kunitsugu Kubota, Sachiko Imamura, Akihito Mase, Nobuhiro Ohtake, Katsuya Ohbuchi, Masahiro Yamamoto, Yuka Sudo, Yasuhito Uezono, Kanako Miyano
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology
Various colonic motor activities are thought to mediate propulsion and mixing/absorption of colonic content. The Japanese traditional medicine daikenchuto (TU-100), which is widely used for postoperative ileus in Japan, accelerates colonic emptying i
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology
Changes in resting membrane potential (RMP) regulate membrane excitability. K+ conductance(s) are one of the main factors in regulating RMP. The functional role of K+ conductances has not been studied the in human gastric corpus smooth muscles (HGCS)
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G532-G539
Hydrogen sulfide (H2S) is an endogenous gaseous mediator affecting many physiological and pathophysiological conditions. Enhanced expression of H2S and reactive nitrogen/oxygen species (RNS/ROS) during inflammation alters cellular excitability via mo
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G378-G388
Slow waves (slow wavesICC) were recorded from myenteric interstitial cells of Cajal (ICC-MY) in situ in the rabbit small intestine, and their properties were compared with those of mouse small intestine. Rabbit slow wavesICCconsisted of an upstroke d
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G434-G441
Abdominal pain and distention are major complaints in irritable bowel syndrome. Abdominal distention is mainly attributed to intraluminal retention of gas or solid contents, which may cause mechanical stress to the gut wall. Visceral hypersensitivity
Autor:
Sunila Mahavadi, John R. Grider, John A. DeSimone, Vijay Lyall, Norman Hurst, Zachary L. Bradley, John F. Kuemmerle, Derek M. Kendig, Karnam S. Murthy
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G1100-G1107
Intraluminal nutrients in the gut affect the peristaltic reflex, although the mechanism is not well defined. Recent evidence supports the presence of taste receptors and their signaling components in enteroendocrine cells, although their function is
Autor:
Lauren E. Peri, Kathleen D. Keef, Caroline A. Cobine, Alexandra G. Sotherton, Sean M. Ward, Kenton M. Sanders
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G1057-G1072
The effector cells and second messengers participating in nitrergic neuromuscular transmission (NMT) were investigated in the mouse internal anal sphincter (IAS). Protein expression of guanylate cyclase (GCα, GCβ) and cyclic GMP-dependent protein k