Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Neuropeptides/metabolism"'
Autor:
Ali Seifinejad, Mergim Ramosaj, Ling Shan, Sha Li, Marie-Laure Possovre, Corinne Pfister, Rolf Fronczek, Lee A. Garrett-Sinha, David Frieser, Makoto Honda, Yoan Arribat, Dogan Grepper, Francesca Amati, Marie Picot, Andrea Agnoletto, Christian Iseli, Nicolas Chartrel, Roland Liblau, Gert J. Lammers, Anne Vassalli, Mehdi Tafti
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120(19). National Academy of Sciences
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT deficiency can also occur i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97057d7c799183cb3bcbacf97011bf
https://doi.org/10.1073/pnas.2220911120
https://doi.org/10.1073/pnas.2220911120
Autor:
Anja Holm, Marie-Laure Possovre, Mojtaba Bandarabadi, Kristine F. Moseholm, Jessica L. Justinussen, Ivan Bozic, René Lemcke, Yoan Arribat, Francesca Amati, Asli Silahtaroglu, Maxime Juventin, Antoine Adamantidis, Mehdi Tafti, Birgitte R. Kornum
Publikováno v:
Holm, Anja; Possovre, Marie-Laure; Bandarabadi, Mojtaba; Moseholm, Kristine F; Justinussen, Jessica L; Bozic, Ivan; Lemcke, René; Arribat, Yoan; Amati, Francesca; Silahtaroglu, Asli; Juventin, Maxime; Adamantidis, Antoine; Tafti, Mehdi; Kornum, Birgitte R (2022). The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio. Proceedings of the National Academy of Sciences of the United States of America-PNAS, 119(17), e2112225119. National Academy of Sciences NAS 10.1073/pnas.2112225119
Holm, A, Possovre, M-L, Bandarabadi, M, Moseholm, K F, Justinussen, J L, Bozic, I, Lemcke, R, Arribat, Y, Amati, F, Silahtaroglu, A, Juventin, M, Adamantidis, A, Tafti, M & Kornum, B R 2022, ' The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 17, e2112225119, pp. e2112225119 . https://doi.org/10.1073/pnas.2112225119
Holm, A, Possovre, M L, Bandarabadi, M, Moseholm, K F, Justinussen, J L, Bozic, I, Lemcke, R, Arribat, Y, Amati, F, Silahtaroglu, A, Juventin, M, Adamantidis, A, Tafti, M & Kornum, B R 2022, ' The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 17 . https://doi.org/10.1073/pnas.2112225119
Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 17, pp. e2112225119
Holm, A, Possovre, M-L, Bandarabadi, M, Moseholm, K F, Justinussen, J L, Bozic, I, Lemcke, R, Arribat, Y, Amati, F, Silahtaroglu, A, Juventin, M, Adamantidis, A, Tafti, M & Kornum, B R 2022, ' The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 17, e2112225119, pp. e2112225119 . https://doi.org/10.1073/pnas.2112225119
Holm, A, Possovre, M L, Bandarabadi, M, Moseholm, K F, Justinussen, J L, Bozic, I, Lemcke, R, Arribat, Y, Amati, F, Silahtaroglu, A, Juventin, M, Adamantidis, A, Tafti, M & Kornum, B R 2022, ' The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 17 . https://doi.org/10.1073/pnas.2112225119
Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 17, pp. e2112225119
Hypocretin (Hcrt), also known as orexin, neuropeptide signaling stabilizes sleep and wakefulness in all vertebrates. A lack of Hcrt causes the sleep disorder narcolepsy, and increased Hcrt signaling has been speculated to cause insomnia, but while th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5daa4e77ffd8aa8cbc665cd9fc957acc
https://boris.unibe.ch/169463/1/pnas.2112225119.pdf
https://boris.unibe.ch/169463/1/pnas.2112225119.pdf
Autor:
Overeem, Sebastiaan, van Litsenburg, Raphaële R.L., Reading, Paul J., Swaab, Dick F., Buijs, Ruud M., Kreier, Felix
Publikováno v:
The Human Hypothalamus: Neuropsychiatric Disorders ISBN: 9780128199732
The Human Hypothalamus: Neuropsychiatric Disorders, 369-385
STARTPAGE=369;ENDPAGE=385;TITLE=The Human Hypothalamus: Neuropsychiatric Disorders
The Human Hypothalamus: Neuropsychiatric Disorders, 369-385
STARTPAGE=369;ENDPAGE=385;TITLE=The Human Hypothalamus: Neuropsychiatric Disorders
As early as the 1920s, pathological studies of encephalitis lethargica allowed Von Economo to correctly identify hypothalamic damage as crucial for the profound associated sleep-related symptoms that helped define the condition. Only over the last 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6df291ae035319f1d103a07d6e77ef4
https://doi.org/10.1016/b978-0-12-819973-2.00025-3
https://doi.org/10.1016/b978-0-12-819973-2.00025-3
Autor:
Emily Witham, Harkaranveer Ratanpal, Nicole K. Littlejohn, Supriya Srinivasan, Jaleh Mesgarzadeh, Rosalind Hussey, Erik Vanstrum
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 3, p e1007305 (2018)
Hussey, R, Littlejohn, N K, Witham, E, Vanstrum, E, Mesgarzadeh, J, Ratanpal, H & Srinivasan, S 2018, ' Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans ', PLoS Genetics, vol. 14, no. 3, e1007305 . https://doi.org/10.1371/journal.pgen.1007305
PLoS Genetics, Vol 14, Iss 3, p e1007305 (2018)
Hussey, R, Littlejohn, N K, Witham, E, Vanstrum, E, Mesgarzadeh, J, Ratanpal, H & Srinivasan, S 2018, ' Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans ', PLoS Genetics, vol. 14, no. 3, e1007305 . https://doi.org/10.1371/journal.pgen.1007305
The mechanisms by which the sensory environment influences metabolic homeostasis remains poorly understood. In this report, we show that oxygen, a potent environmental signal, is an important regulator of whole body lipid metabolism. C. elegans oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab53a415685e15d5af84d08d59621622
https://doi.org/10.1101/142422
https://doi.org/10.1101/142422
Autor:
Mithula Sivasaravanaparan, Louise Ørum Olesen, Alicia A. Babcock, Elena V. Bouzinova, Bente Finsen, Ove Wiborg, Maurizio Severino, Mark J. West
Publikováno v:
Olesen, L Ø, Sivasaravanaparan, M, Severino, M, Babcock, A A, Bouzinova, E V, West, M J, Wiborg, O & Finsen, B 2017, ' Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP swe /PS1 dE9 transgenic mice : Effect of long-term treatment with paroxetine ', Neurobiology of Disease, vol. 104, pp. 50-60 . https://doi.org/10.1016/j.nbd.2017.04.021
Olesen, L O, Sivasaravanaparan, M, Severino, M, Babcock, A A, Bouzinova, E V, West, M J, Wiborg, O & Finsen, B 2017, ' Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP(swe)/PS1(dE9) transgenic mice : Effect of long-term treatment with paroxetine ', Neurobiology of Disease, vol. 104, pp. 50-60 . https://doi.org/10.1016/j.nbd.2017.04.021
Neurobiology of Disease, Vol 104, Iss, Pp 50-60 (2017)
Olesen, L O, Sivasaravanaparan, M, Severino, M, Babcock, A A, Bouzinova, E V, West, M J, Wiborg, O & Finsen, B 2017, ' Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP(swe)/PS1(dE9) transgenic mice : Effect of long-term treatment with paroxetine ', Neurobiology of Disease, vol. 104, pp. 50-60 . https://doi.org/10.1016/j.nbd.2017.04.021
Neurobiology of Disease, Vol 104, Iss, Pp 50-60 (2017)
Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8f25716018be6de0012dd443cd518b
https://portal.findresearcher.sdu.dk/da/publications/58bd56a7-b25c-42b8-b573-c6bafef6973a
https://portal.findresearcher.sdu.dk/da/publications/58bd56a7-b25c-42b8-b573-c6bafef6973a
Autor:
Delhanty, P.J.D, van der Lely, A.J
Obesity is an epidemic problem not limited to Western society, but also in emerging industrial nations with large populations, especially in Asia. The connection between the gut and the brain is probably one of the most promising therapeutic targets
Autor:
Rawien Balesar, Paul J. Lucassen, D. P. Noske, J. Wouda, Dick F. Swaab, A. A. Sluiter, Johannes C. Baayen, A.-M. Van Dam, R. W. H. Verwer, C. M. F. Dirven
Publikováno v:
Brain, 130, 3321-3335. Oxford University Press
Verwer, R W H, Sluiter, A A, Balesar, R A, Baayen, J C, Noske, D P, Dirven, C M F, Wouda, J, van Dam, A M, Lucassen, P J & Swaab, D F 2007, ' Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin ', Brain, vol. 130, no. Pt 12, pp. 3321-35 . https://doi.org/10.1093/brain/awm264
Brain, 130(Pt 12), 3321-35. Oxford University Press
Verwer, R W H, Sluiter, A A, Balesar, R A, Baayen, J C, Noske, D P, Dirven, C M F, Wouda, J, van Dam, A M, Lucassen, P J & Swaab, D F 2007, ' Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin ', Brain, vol. 130, no. Pt 12, pp. 3321-35 . https://doi.org/10.1093/brain/awm264
Brain, 130(Pt 12), 3321-35. Oxford University Press
Doublecortin (DCX) is a microtubule-associated protein expressed by migrating neuroblasts and is considered to be a reliable marker of neurogenesis. DCX has been used to study the relation between neurogenesis in adult human brain and neurological an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef2da0b92653d43f403cafc71ac3a6d
https://doi.org/10.1093/brain/awm264
https://doi.org/10.1093/brain/awm264
Autor:
Carine Monnier, Oualid Sbai, Philippe Rondard, Jean-Pierre Hardelin, Catherine Dodé, Jean-Philippe Pin
Publikováno v:
FASEB Journal
FASEB Journal, 2014, 28 (8), pp.3734--44. ⟨10.1096/fj.13-243402⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2014, 28 (8), pp.3734--44. ⟨10.1096/fj.13-243402⟩
FASEB Journal, 2014, 28 (8), pp.3734--44. ⟨10.1096/fj.13-243402⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2014, 28 (8), pp.3734--44. ⟨10.1096/fj.13-243402⟩
International audience; Various missense mutations in the gene coding for prokineticin receptor 2 (PROKR2), a G-protein-coupled receptor, have been identified in patients with Kallmann syndrome. However, the functional consequences of these mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca195fe525c5c70ea28fe411f6c8420
https://pubmed.ncbi.nlm.nih.gov/24830383
https://pubmed.ncbi.nlm.nih.gov/24830383
Autor:
Danièle Machard, Benoît Saint-Mleux, Laurence Bayer, Mauro Serafin, Emmanuel Eggermann, Michel Muhlethaler, Barbara E. Jones
Publikováno v:
Neuroscience, Vol. 108, No 2 (2001) pp. 177-181
The orexins (orexin A and B, also known as hypocretin 1 and 2) are two recently identified neuropeptides (de Lecea et al., 1998; Sakurai et al., 1998) which are importantly implicated in the control of wakefulness (for reviews see Hungs and Mignot, 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4a418544ac4b93b5ffca1ee33a92d6
https://doi.org/10.1016/s0306-4522(01)00512-7
https://doi.org/10.1016/s0306-4522(01)00512-7