Cortical interneurons in schizophrenia – cause or effect?

Autor: Prkačin, Matija Vid, Banovac, Ivan, Petanjek, Zdravko, Hladnik, Ana

Publikováno v: Croatian Medical Journal. 64:110-122

GABAergic cortical interneurons are important components of cortical microcircuits. Their alterations are associated with a number of neurological and psychiatric disorders, and are thought to be especially important in the pathogenesis of schizophre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d839c28420241a53c85d00db7bd2e105
https://doi.org/10.3325/cmj.2023.64.110

Prenatal development of the human entorhinal cortex

Autor: Goran Šimić, Željka Krsnik, Vinka Knezović, Zlatko Kelović, Mathias Lysholt Mathiasen, Alisa Junaković, Milan Radoš, Damir Mulc, Ena Španić, Giulia Quattrocolo, Vanessa Jane Hall, Laszlo Zaborszky, Mario Vukšić, Francisco Olucha Bordonau, Ivica Kostović, Menno P. Witter, Patrick R. Hof

Publikováno v: Journal of Comparative Neurology. 530:2711-2748

Little is known about the development of the human entorhinal cortex (EC), a major hub in a widespread network for learning and memory, spatial navigation, high-order processing of object information, multimodal integration, attention and awareness,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5ea29494e5943e26471bbc362ca0c7
https://doi.org/10.1002/cne.25344

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

Autor: Katarina Stoklund Dittlau, Lisanne Terrie, Pieter Baatsen, Axelle Kerstens, Lim De Swert, Rekin’s Janky, Nikky Corthout, Pegah Masrori, Philip Van Damme, Poul Hyttel, Morten Meyer, Lieven Thorrez, Kristine Freude, Ludo Van Den Bosch

Publikováno v: Stoklund Dittlau, K, Terrie, L, Baatsen, P, Kerstens, A, De Swert, L, Janky, R, Corthout, N, Masrori, P, Van Damme, P, Hyttel, P, Meyer, M, Thorrez, L, Freude, K & Van Den Bosch, L 2023, ' FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms ', Molecular Neurodegeneration, vol. 18, no. 1, 5 . https://doi.org/10.1186/s13024-022-00591-3

Background Astrocytes play a crucial, yet not fully elucidated role in the selective motor neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities, astrocytes provide important neuronal homeostatic support, however this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1a13ae551ab32d6231d22979198152
https://doi.org/10.1186/s13024-022-00591-3

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition

Autor: Laura Mahoney-Sanchez, Hind Bouchaoui, Ibrahim Boussaad, Aurélie Jonneaux, Kelly Timmerman, Olivier Berdeaux, Scott Ayton, Rejko Krüger, James A. Duce, David Devos, Jean-Christophe Devedjian

Publikováno v: Cell Reports
Cell Reports, 2022, 40 (8), pp.111231. ⟨10.1016/j.celrep.2022.111231⟩

International audience; There is a continued unmet need for treatments that can slow Parkinson's disease progression due to the lack of understanding behind the molecular mechanisms underlying neurodegeneration. Since its discovery, ferroptosis has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b27c4e302eadacc48ae4fca29821df5
https://hal.inrae.fr/hal-03813276/file/mahoney-sanchez_2022_vol40_111231_cell_rep.pdf

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

Autor: Carmen Klein Herenbrink, Jonatan Fullerton Støier, William Dalseg Reith, Abeer Dagra, Miguel Alejandro Cuadrado Gregorek, Reto B. Cola, Tommaso Patriarchi, Yulong Li, Lin Tian, Ulrik Gether, Freja Herborg

Publikováno v: Communications Biology, 5
Communications biology, vol 5, iss 1
Klein Herenbrink, C, Støier, J F, Reith, W D, Dagra, A, Gregorek, M A C, Cola, R B, Patriarchi, T, Li, Y, Tian, L, Gether, U & Herborg, F 2022, ' Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors ', Communications Biology, vol. 5, no. 1, 578 . https://doi.org/10.1038/s42003-022-03488-5

Dopamine supports locomotor control and higher brain functions such as motivation and learning. Consistently, dopaminergic dysfunction is involved in a spectrum of neurological and neuropsychiatric diseases. Detailed data on dopamine dynamics is need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78147204309663f47e51d360fd4c77c2
https://hdl.handle.net/20.500.11850/553517