Zobrazeno 1 - 10
of 2 580
pro vyhledávání: '"Neuronal survival"'
Autor:
Qiu-Xia Xiao, Lu-Lu Xue, Ya-Xin Tan, Li-Ren Huangfu, Li Chen, Chen-Yang Zhai, Rui-Fang Ma, Mohammed Al-Hawwas, Hong-Su Zhou, Ting-Hua Wang, Xin-Fu Zhou, Liu-Lin Xiong
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117338- (2024)
A recent study has introduced a recombinant fusion protein, consisting of the extracellular domain (ECD) of p75 and the Fc fragment of human immunoglobulin IgG1 (p75ECD-Fc), as a multifaceted agent within the nervous system. This research aimed to as
Externí odkaz:
https://doaj.org/article/78e7b74fe3aa459cb2f33ac9dde96efe
Autor:
Jinmei Sun, Wei Zhang, Zheng Zachory Wei, Xiaopeng Song, Liu Jian, Feng Jiang, Shuanglin Wang, Haibo Li, Yongbo Zhang, Houzhen Tuo, The CtrLyin Group
Publikováno v:
Chinese Neurosurgical Journal, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms (NMS) such as anxiety, cognitive dysfunction, depression, hyposmia, and sleep dis
Externí odkaz:
https://doaj.org/article/62c6145fbd5140a09449eb1e339b0a38
Autor:
Silmara De Lima, Bruno Siqueira Mietto, Vinicius Toledo Ribas, Victor Tulio Ribeiro-Resende, Alexandre Leite Rodrigues Oliveira, Kevin K. Park
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/a51dbe58e97a4cd1aaa9020209384662
Autor:
Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei, Fang Huang
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract Parkinson’s disease (PD) is mainly characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation mediated by overactivated microglia and astrocytes. NLRC5 (nucleoti
Externí odkaz:
https://doaj.org/article/d737bffdd402413a88282475ecf69a39
Autor:
Jeonghoon Choi, Hiroaki Kii, Justin Nelson, Yoichi Yamazaki, Fumiki Yanagawa, Atsushi Kitajima, Takayuki Uozumi, Yasujiro Kiyota, Dimple Doshi, Kenneth Rhodes, Robert Scannevin, Heather Sadlish, Chee Yeun Chung
Publikováno v:
SLAS Technology, Vol 28, Iss 2, Pp 63-69 (2023)
The development of phenotypic assays with appropriate analyses is an important step in the drug discovery process. Assays using induced pluripotent stem cell (iPSC)-derived human neurons are emerging as powerful tools for drug discovery in neurologic
Externí odkaz:
https://doaj.org/article/718216d2882f4578a15d3fa8eb3f2afb
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Neurotrophin-3 (NT3) is a neuroprotective growth factor that induces the development, maintenance and survival of neurons. This study aims to localize NT3-expressing cells in the adult zebrafish brain and examine the role of NT3 in a ze
Externí odkaz:
https://doaj.org/article/0edfdc6891364135af46fbb6e8fedf78
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1786 (2024)
Stroke results in neuronal cell death, which causes long-term disabilities in adults. Treatment options are limited and rely on a narrow window of opportunity. Apoptosis inhibitors demonstrate efficacy in improving neuronal cell survival in animal mo
Externí odkaz:
https://doaj.org/article/10322d6fd6e442cfbb4651ab5aca8ab3
Autor:
Mirjana Antonijevic, Despoina Charou, Audrey Davis, Thomas Curel, Maria Valcarcel, Isbaal Ramos, Patricia Villacé, Sylvie Claeysen, Patrick Dallemagne, Achille Gravanis, Ioannis Charalampopoulos, Christophe Rochais
Publikováno v:
Molecules, Vol 29, Iss 2, p 515 (2024)
One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal death. Endogenous neurotrophins consist of the major neuroprotective factors, while brain-de
Externí odkaz:
https://doaj.org/article/0068818731ab4fbd88ebde7ede7d77ef
Publikováno v:
Ibrain, Vol 8, Iss 3, Pp 302-313 (2022)
Abstract This study aimed to decipher the effect of glycoprotein nonmetastatic melanoma protein B (GPNMB) on neonatal hypoxic–ischemic encephalopathy (NHIE) and its potential molecular mechanism. The hypoxic–ischemic (HI) model was established in
Externí odkaz:
https://doaj.org/article/d8cae1c4268747c7bab93cedb4bb7bdc
Autor:
Marianna Tassinari, Beatrice Uguagliati, Stefania Trazzi, Camilla Bruna Cerchier, Ottavia Vera Cavina, Nicola Mottolese, Manuela Loi, Giulia Candini, Giorgio Medici, Elisabetta Ciani
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106146- (2023)
Mutations in the CDKL5 gene are the cause of CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental condition characterized by early-onset epilepsy, motor impairment, intellectual disability, and autistic features. A mouse model of CDD
Externí odkaz:
https://doaj.org/article/e4716d25c1e3418cbbfe63ef6ef10df1