Zobrazeno 1 - 10
of 2 705
pro vyhledávání: '"Neuronal Loss"'
Autor:
Shahab Ghaderi, Parsa Gholipour, Samaneh Safari, Seyed Mahdi Sadati, Shahla Eyvari Brooshghalan, Rezvan Sohrabi, Khodabakhsh Rashidi, Alireza Komaki, Iraj Salehi, Abdolrahman Sarihi, Mohammad Zarei, Siamak Shahidi, Masome Rashno
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117405- (2024)
Traumatic brain injury (TBI) is a significant contributor to global mortality and disability, and there is still no specific drug available to treat cognitive deficits in survivors. Vanillic acid (VA), a bioactive phenolic compound, has shown protect
Externí odkaz:
https://doaj.org/article/4cb284fe76aa4c6db798117511c1aef2
Autor:
Shahab Ghaderi, Masome Rashno, Shahla Eyvari Brooshghalan, Iraj Salehi, Abdolrahman Sarihi, Siamak Shahidi, Khodabakhsh Rashidi, Rasool Haddadi, Alireza Komaki
Publikováno v:
Journal of Functional Foods, Vol 120, Iss , Pp 106381- (2024)
This study investigated the efficacy of p-coumaric acid (p-CA), a natural phenolic compound, on traumatic brain injury (TBI)-induced spatial cognitive deficits and the possible involved mechanisms. Rats received p-CA (100 mg/kg, orally) 30 min after
Externí odkaz:
https://doaj.org/article/ccbac53ba6e043a8a6615a94bd1f227c
Publikováno v:
Brain Research Bulletin, Vol 214, Iss , Pp 110994- (2024)
Synaptotagmin-7 (SYT7) has been proposed as an innovative therapeutic strategy for treating cognitive impairment, while its contribution to Alzheimer’s disease (AD) alleviation remains unclear. In this study, we investigated the role and potential
Externí odkaz:
https://doaj.org/article/7b950cc6f92348a0ab50b3285fa3967c
Autor:
Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angelo
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 9, Pp 1991-1997 (2024)
Huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditi
Externí odkaz:
https://doaj.org/article/6d3b3d099778440692b6af4e5ac9b1ac
Publikováno v:
Journal of Advanced Research, Vol 54, Iss , Pp 105-118 (2023)
Background: Synaptic dysfunction is a major contributor to Alzheimeŕs disease (AD) pathogenesis in addition to the formation of neuritic β-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. However, how these features
Externí odkaz:
https://doaj.org/article/c8db61961ddf4949b9acbca33d3b4387
Autor:
Manish Moghe, Sang-Soo Kim, Miaoyin Guan, Antonina Rait, Kathleen F. Pirollo, Joe B. Harford, Esther H. Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7539 (2024)
Due to their inhibition of acetylcholinesterase, organophosphates are among the most toxic of chemicals. Pralidoxime (a.k.a 2-PAM) is the only acetylcholinesterase reactivator approved in the U.S., but 2-PAM only poorly traverses the blood–brain ba
Externí odkaz:
https://doaj.org/article/fa479bdacb484acfb87478c121a16f22
Publikováno v:
Translational Neuroscience, Vol 14, Iss 1, Pp 231-55 (2023)
Externí odkaz:
https://doaj.org/article/6434dcdc9e40482e807d18b086dbbf1c
Autor:
Joshua T. Emmerson, Janice C. Malcolm, Sonia Do Carmo, Phuoc Nguyen, Lionel Breuillaud, Julio C. Martinez-Trujillo, A. Claudio Cuello
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106317- (2023)
In tauopathies such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), the microtubule associated protein tau undergoes conformational and posttranslational modifications in a gradual, staged pathological process. While brain atrophy and
Externí odkaz:
https://doaj.org/article/e07b9091546442c8b600434a27f0a058
Autor:
Shirley Jaqueline Szriber, Leonardo Santana Novaes, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Deise Carla Almeida Leite-Dellova
Publikováno v:
Veterinary World, Vol 15, Iss 11, Pp 2543-2550 (2022)
Background and Aim: Cortisol binds to mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) found in the hippocampus. The balanced expression of these receptors is essential to neuronal survival as MR and GR activations have antiapoptotic
Externí odkaz:
https://doaj.org/article/d58d2f980c2745a893800cfda712d843
Autor:
Keke Hao, Huiling Wang, Yuejin Zhang, Xinhui Xie, Huan Huang, Cheng Chen, Shilin Xu, Rui Xu, Chang Shu, Zhongchun Liu, Yuan Zhou, Gavin P. Reynolds, Gaohua Wang
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background Early life stress (ELS) is associated with the development of schizophrenia later in life. The hippocampus develops significantly during childhood and is extremely reactive to stress. In rodent models, ELS can induce neuroinflamma
Externí odkaz:
https://doaj.org/article/88229cde5577413fb2bc848fff2ec95f