Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Neuron fate specification"'
Publikováno v:
DNA and Cell Biology. 39:2143-2153
The role of secreted exosomes during dopaminergic (DA) neuron differentiation is still unknown. To investigate the roles of exosomes in DA neuron fate specification, we profiled exosomal microRNAs ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0986de72ad93518d09dac2ef7606cd
https://doi.org/10.1089/dna.2020.5931
https://doi.org/10.1089/dna.2020.5931
Publikováno v:
Gene. 738
Cytoplasmic polyadenylation element binding proteins (CPEBs) are widely conserved proteins that regulate the length of poly(A) tails in the cytoplasm, regulate translation, and regulate mRNA transport. While CPEBs are best known for regulating matern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ce1db2e60af35f80171593ffd900e3
https://pubmed.ncbi.nlm.nih.gov/32057929
https://pubmed.ncbi.nlm.nih.gov/32057929
Autor:
H. Isaac Chen, Hao Wu, Lisa A. Briand, Zhexing Wen, Ahmet Hoke, Guo Li Ming, Kenong Su, Shiying Li, John A. Wolf, Ethan M. Goldberg, Lu Lu, Sooyoung Huh, R. Christopher Pierce, Phuong T.T. Nguyen, Hongjun Song, Xuyu Qian, Andre U. Deutschmann, Yijing Su, Sarshan R. Pather, Christopher D. Adam, Sarah E. Swinford-Jackson, Fadi Jacob, Xiaosong Gu
Publikováno v:
Cell Stem Cell
Human brain organoids provide unique platforms for modeling development and diseases by recapitulating the architecture of the embryonic brain. However, current organoid methods are limited by interior hypoxia and cell death due to insufficient surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ad40b4596623a647d4a6b491bf297f
https://doi.org/10.1016/j.stem.2020.02.002
https://doi.org/10.1016/j.stem.2020.02.002
Autor:
Susumu Miyamoto, Toshiyuki Ohtsuka, Masanori Goto, Masato Hojo, Masashi Kitagawa, Aya Kita, Mitsushige Ando, Ryoichiro Kageyama
Publikováno v:
Brain Research. 1625:206-217
The pituitary gland is a critical endocrine organ regulating diverse physiological functions, including homeostasis, metabolism, reproduction, and growth. It is composed of two distinct entities: the adenohypophysis, including the anterior and interm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6c6e9446483793fa3d470493f0ad7d
https://doi.org/10.1016/j.brainres.2015.08.045
https://doi.org/10.1016/j.brainres.2015.08.045
Akademický článek
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Autor:
Daniel H. Geschwind, Jennifer K. Lowe, Benjamin J. Blencowe, Manuel Irimia, Jerry Huang, Luis de la Torre Ubieta, Virpi Leppa, Steve Horvath, Neelroop N. Parikshak, Michael J. Gandal, Vivek Swarup, Gokul Ramaswami, T. Grant Belgard, Christopher Hartl
Publikováno v:
Nature, vol 540, iss 7633
Nature
Nature
Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions are profoundly heterogeneous but may converge on common pathways that are not yet well understood(1–3). Here, through post-mortem genome-wide transcripto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14277f161e347d3dcafe975abe60276f
https://escholarship.org/uc/item/8m81p43x
https://escholarship.org/uc/item/8m81p43x
Autor:
Judit Kuechler, Mark A. Ungless, Ines Jaeger, I-Cheng Chen, Charles Arber, Thulasi Naveenan, Diana Pritzsche, Jessica R. Risner-Janiczek, Meng Li
Publikováno v:
Development; Vol 138
Effective induction of midbrain-specific dopamine (mDA) neurons from stem cells is fundamental for realizing their potential in biomedical applications relevant to Parkinson’s disease. During early development, the Otx2-positive neural tissues are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5867acc9fca67e90fc74f4adbffdb6
https://doi.org/10.1242/dev.066746
https://doi.org/10.1242/dev.066746
Autor:
Suewei Lin, Tzumin Lee
Publikováno v:
Developmental Dynamics. 241:57-68
Generating diverse neurons in the central nervous system involves three major steps. First, heterogeneous neural progenitors are specified by positional cues at early embryonic stages. Second, neural progenitors sequentially produce neurons or interm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340179f39674d345ea160adeddfeb000
https://doi.org/10.1002/dvdy.22739
https://doi.org/10.1002/dvdy.22739
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 7, p e1006884 (2017)
PLoS Genetics, Vol 13, Iss 7, p e1006884 (2017)
In terrestrial vertebrates such as birds and mammals, neurotrophin receptor expression is considered fundamental for the specification of distinct somatosensory neuron types where TrkA, TrkB and TrkC specify nociceptors, mechanoceptors and propriocep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789c9259a94f57492ef508c531c4338a
https://doi.org/10.1371/journal.pgen.1006884
https://doi.org/10.1371/journal.pgen.1006884
Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14382 (2010)
PLoS ONE
PLoS ONE
Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive functions, extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles within neocortex and hippocampus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4b6214837b1545066b606aaf022cb7
https://doi.org/10.1371/journal.pone.0014382
https://doi.org/10.1371/journal.pone.0014382