Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Neurological Disorders/Multiple Sclerosis and Related Disorders"'
1
The epidemiology of multiple sclerosis in Scotland: inferences from hospital admissions
Autor: George C. Ebers, Ryan McLaughlin, Adam E. Handel, Anastasia Fries, Sreeram V. Ramagopalan, Lynne Jarvis
Publikováno v: PLoS ONE, Vol 6, Iss 1, p e14606 (2011)
PLoS ONE
Background Multiple sclerosis (MS) is a neurological disorder with a highly characteristic disease distribution. Prevalence and incidence in general increase with increasing distance from the equator. Similarly the female to male sex ratio increases
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca843f0a186580959c3c03e42493ed08
http://europepmc.org/articles/PMC3029296?pdf=render
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2
Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO)
Autor: Kazuo Suzuki, Bruce J. Brew, Osamu Takikawa, Rosanne M. Taylor, F. Lamoury, David W. Walker, Juliana Croitoru-Lamoury, Michael Caristo
Publikováno v: PLoS ONE, Vol 6, Iss 2, p e14698 (2011)
PLoS ONE
The kynurenine pathway (KP) of tryptophan metabolism is linked to antimicrobial activity and modulation of immune responses but its role in stem cell biology is unknown. We show that human and mouse mesenchymal and neural stem cells (MSCs and NSCs) e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d18bc817618fb357b0af4080e2531b
http://europepmc.org/articles/PMC3040184?pdf=render
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3
Real Time Imaging of Human Progenitor Neurogenesis
Autor: Jarett C. Thelen, Aaron D. Nelson, Jeffrey R. Grinager, Clive N. Svendsen, Thomas Keenan
Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13187 (2010)
Human neural progenitors are increasingly being employed in drug screens and emerging cell therapies targeted towards neurological disorders where neurogenesis is thought to play a key role including developmental disorders, Alzheimer's disease, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd41912b0afaecee3cfd2f7a37876cc
http://europepmc.org/articles/PMC2951355
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4
Evaluation of Soluble Junctional Adhesion Molecule-A as a Biomarker of Human Brain Endothelial Barrier Breakdown
Autor: Najbauer, Joseph, Haarmann, Axel, Deiß, Annika, Prochaska, Jürgen, Foerch, Christian, Weksler, Babette, Romero, Ignacio, Couraud, Pierre-Olivier, Stoll, Guido, Rieckmann, Peter, Buttmann, Mathias
Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13568 (2010)
Background: An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation in no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dd7a8eac2efd49bf5d8c9e8b473a2d
http://europepmc.org/articles/PMC2958838
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5
A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis
Autor: Brian D. Tait, Bruce V. Taylor, James S. Wiley, Melanie Bahlo, Graeme J. Stewart, Kaushal S. Gandhi, Jim Stankovich, Patrick Danoy, Michael D. Varney, Simon J. Foote, Justin P. Rubio, Trevor J. Kilpatrick, Matthew A. Brown, Jac Charlesworth, David R. Booth, Sharon R. Browning, Robert Heard, Helmut Butzkueven, Laura J. Johnson, Judith Field
Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13454 (2010)
We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we identified seven SNPs that we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f933a154a205e62fad90baeacf2bc4e6
http://europepmc.org/articles/PMC2964313
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6
Delayed Onset of Experimental Autoimmune Encephalomyelitis in Olig1 Deficient Mice
Autor: Yoshinori Mitamura, Hiroshi Yoshida, Kazuhiko Namekata, Xiaoli Guo, Yoh Matsumoto, Takayuki Harada, Chikako Harada
Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e744 (2010)
BACKGROUND: Olig1 is a basic helix-loop-helix (bHLH) transcription factor that is essential for oligodendrogenesis and efficient remyelination. However, its role in neurodegenerative disorders has not been well-elucidated. METHODOLOGY/PRINCIPAL FINDI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e8695dba3a388e66a57d39cb8b1516
http://europepmc.org/articles/PMC2947525
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7
Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model
Autor: Hao-jie Lin, Stephen W. Coons, Jun-xiang Yin, Fu-Dong Shi, Jiong Shi, Ru-lan Liu, Chong-bo Zhao, Sandra Kuniyoshi, Jiang-long Tu
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12400 (2010)
PLoS ONE
Background Experimental autoimmune encephalomyelitis (EAE) models are important vehicles for studying the effect of infectious elements such as Pertussis toxin (PTx) on disease processes related to acute demyelinating encephalomyelitis (ADEM) or mult
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7a888482d0b49dd5cc47f76e71a2d4
http://europepmc.org/articles/PMC2928301?pdf=render
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8
PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER
Autor: Paul M. Epstein, William Housley, Stefan Brocke, Barbara E. Kream, Michael P. DeNinno, Michelle Marie Claffey, Robert B. Clark, S Z Ben-Sasson, Amanda G. Vang, Hongli Dong
Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12011 (2010)
Background Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5327d40fbf5af416e0c523b275c0789
http://europepmc.org/articles/PMC2918507
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9
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
Autor: Moses Rodriguez, Chandra Deb, Christopher L. German, Reghann G. LaFrance-Corey, Anthony J. Windebank, Charles L. Howe, William F. Schmalstieg, Brian M. Sauer, Huan Wang
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12478 (2010)
PLoS ONE
Background The objective of this study was to test the hypothesis that CD8+ T cells directly mediate motor disability and axon injury in the demyelinated central nervous system. We have previously observed that genetic deletion of the CD8+ T cell eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5563f0a3a6fe7f882243eb5bfb9fbf52
http://europepmc.org/articles/PMC2930011?pdf=render
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10
HDL interfere with the binding of T cell microparticles to human monocytes to inhibit pro-inflammatory cytokine production
Autor: Valery Combes, Karim J. Brandt, Dorothée Faille, Rakel Carpintero, Lyssia Gruaz, Danielle Burger, Georges E. Grau, Anna Scanu
Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11869 (2010)
PLOS ONE, Vol. 5, No 7 (2010) P. e11869
PLoS ONE
BackgroundDirect cellular contact with stimulated T cells is a potent mechanism that induces cytokine production in human monocytes in the absence of an infectious agent. This mechanism is likely to be relevant to T cell-mediated inflammatory disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b623fe6679596d393a407d4851da03
https://hdl.handle.net/10453/41491
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