Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Neurogenin-2"'
Publikováno v:
Cancer Biology & Medicine, Vol 18, Iss 3, Pp 860-874 (2021)
Objective: Glioblastoma (GBM) is the most prevalent and aggressive adult primary cancer in the central nervous system. Therapeutic approaches for GBM treatment are under intense investigation, including the use of emerging immunotherapies. Here, we p
Externí odkaz:
https://doaj.org/article/303bb03bd996492f9a4845a1811d0bfc
Publikováno v:
Cancer Biology & Medicine
Cancer Biology & Medicine, Vol 18, Iss 3, Pp 860-874 (2021)
Cancer Biology & Medicine, Vol 18, Iss 3, Pp 860-874 (2021)
Glioblastoma (GBM) is the most prevalent and aggressive adult primary cancer in the central nervous system (CNS). Therapeutic approaches for glioblastoma are under intense investigation, such as the emerging immunotherapy, but so far only marginal pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bdb7f492b79dcf6841b8fed8285628
http://europepmc.org/articles/PMC8330525
http://europepmc.org/articles/PMC8330525
Publikováno v:
Stem Cell Reports
Summary Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly reproducible differentiation of mature and functional neurons. Exog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bf7d67c04d8714593365188d750920
https://doi.org/10.1016/j.stemcr.2021.11.015
https://doi.org/10.1016/j.stemcr.2021.11.015
Autor:
CHALIL, LEON
Using a genetic disorder and patient samples, the work in this thesis provides novel insights into the underlying causes of brain and nerve disorders. Patients with this disorder are missing a large amount of genetic material, and can develop disorde
Externí odkaz:
http://hdl.handle.net/11375/30493
Autor:
Michael F. Wells, James Nemesh, Sulagna Ghosh, Jana M. Mitchell, Max R. Salick, Curtis J. Mello, Daniel Meyer, Olli Pietilainen, Federica Piccioni, Ellen J. Guss, Kavya Raghunathan, Matthew Tegtmeyer, Derek Hawes, Anna Neumann, Kathleen A. Worringer, Daniel Ho, Sravya Kommineni, Karrie Chan, Brant K. Peterson, Joseph J. Raymond, John T. Gold, Marco T. Siekmann, Emanuela Zuccaro, Ralda Nehme, Ajamete Kaykas, Kevin Eggan, Steven A. McCarroll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdde615d08b61500d6ebedf50ae67f53
https://hdl.handle.net/11577/3483040
https://hdl.handle.net/11577/3483040
Autor:
Yu Zhao, Jinling Wang, Jiwei Du, Baixiang Li, Xingchun Gou, Jiannan Liu, Lichao Hou, Hanfei Sang, Bin Deng
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Neurogenin-2 (Ngn2) is a basic helix-loop-helix (bHLH) transcription factor that contributes to the identification and specification of neuronal fate during neurogenesis. In our previous study, we found that Ngn2 plays an important role in alleviatin
Externí odkaz:
https://doaj.org/article/a994f2aea505496985533c240876d24d
Akademický článek
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Autor:
Mai Har Sham, Martin Cheung, Jialin Hong, Jessica Aijia Liu, Andrew Tai, Kathryn S.E. Cheah, May Pui Lai Cheung, Chi Wai Cheung
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The neuron–glial lineage segregation of NC progenitors forming the DRG is essential for peripheral nervous system development. However, hierarchical transcriptional control does not explain how this lineage bifurcation occurs. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b439227c030512a78261d3b652e608c
http://europepmc.org/articles/PMC7049171
http://europepmc.org/articles/PMC7049171
Autor:
Daniel M. Fass, Roberta L. Beauchamp, Steven P. Angus, Chialin Cheng, Kenneth S. Kosik, Timothy J. Stuhlmiller, Bradford C. Dickerson, Bruce L. Miller, Debasis Patnaik, Danielle A. Feldman, Jared I Richardson, Stephen J. Haggarty, Hailey Olafson, Surya A. Reis, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Eric T. Wang, Sally Temple, Emily T Adams, M. Catarina Silva
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons ultimately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648e69bd4afba94c17b3f3502a46e0b7
http://europepmc.org/articles/PMC8382845
http://europepmc.org/articles/PMC8382845
Autor:
Li-Hsin Chang, Yu-Jie Huang, Hung-Chih Kuo, Chun-Lien Chih, I-Hui Lee, Wan-Ci Chen, Shiang-Suo Huang, Yi Hsuan Lee
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor activated by environmental agonists and dietary tryptophan metabolites for the immune response and cell cycle regulation. Emerging evidence suggests that AHR ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771baa9fac620f22f9132fc43caa75c1
http://link.springer.com/article/10.1186/s12974-019-1572-7
http://link.springer.com/article/10.1186/s12974-019-1572-7