Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Neurofibrillary Tangles/pathology"'
Autor:
Judith A. Steen, Dinorah Jean-Gilles, Pieter Beerepoot, Naomi Klickstein, Bradley T. Hyman, Mark B. De Los Santos, Tarun V. Kamath, Renee Moore, Arthur Viode, Aurélien Lathuilière, Lori B. Chibnik, Matthew P. Frosch, Ryan C. Clark, Derek H. Oakley, Alberto Serrano-Pozo, Benjamin D. Moore, Fiona Elwood, Rudolph E. Tanzi, Diana L. Corjuc, Simon Dujardin, Analiese R. Fernandes, Matthew E. Kennedy, Patrick M. Dooley, Bianca T. Corjuc, Kristina Mullin, Caitlin Commins, Kevin Atchison
Publikováno v:
Nat Med
Nature medicine, Vol. 26, No 8 (2020) pp. 1256-1263
Nature medicine, Vol. 26, No 8 (2020) pp. 1256-1263
Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of rates of cognitive decline1. The spread of tau aggregates (neurofibrillary tangles) across the cerebral cortex para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7bb689b9606b3271da239615caaeaa
https://pubmed.ncbi.nlm.nih.gov/33514949
https://pubmed.ncbi.nlm.nih.gov/33514949
Autor:
Alessandra Canuto, Patrick R. Hof, Panteleimon Giannakopoulos, Gabriel Gold, Eniko Veronika Kovari, François Herrmann, Constantin Bouras
Publikováno v:
Acta Neuropathologica, Vol. 106, No 1 (2003) pp. 83-88
Scopus-Elsevier
Scopus-Elsevier
Previous studies reported an association between cortical Lewy body (LB) formation and dementia in Parkinson's disease (PD). However, it is unclear whether cognitive decline in this disorder is related to specific patterns of LB distribution within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6f03b6caa39266e585df60f7de64ed
https://doi.org/10.1007/s00401-003-0705-2
https://doi.org/10.1007/s00401-003-0705-2
Autor:
Nathalie Le Bastard, Sylvie Slaets, Aline Verstraeten, Jean-Jacques Martin, Kristel Sleegers, Jill Luyckx, Christine Van Broeckhoven, Jessie Theuns, Evelyn De Leenheir, Sebastiaan Engelborghs
Publikováno v:
Journal of Alzheimer's disease
A significant proportion of patients with dementia with Lewy bodies (DLB) show Alzheimers disease (AD) pathology like senile plaques and neurofibrillary tangles. Biomarkers in cerebrospinal fluid (CSF), such as amyloid-β1-42 (Aβ1-42), total tau (T-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d1725b09f1356dc63f0714a67b8f1e
https://pubmed.ncbi.nlm.nih.gov/23364139
https://pubmed.ncbi.nlm.nih.gov/23364139
Autor:
Irina Alafuzoff, Thomas Wisniewski, Walter A. Kukull, James B. Leverenz, Juan C. Troncoso, Seth Love, Dietmar Rudolf Thal, David M. A. Mann, Vahram Haroutunian, Thomas G. Beach, Eniko Veronika Kovari, Barbara J. Crain, Thomas J. Montine, Charles Duyckaerts, Takeshi Iwatsubo, Peter Davies, Eileen H. Bigio, John C. Morris, Christine M. Hulette, Ian R. A. Mackenzie, Rudolph J. Castellani, Kurt A. Jellinger, Ann C. McKee, Kelly Del Tredici, Heiko Braak, Randall L. Woltjer, Matthew P. Frosch, Eliezer Masliah, Peter T. Nelson, John Q. Trojanowski, Bradley T. Hyman, Joshua A. Sonnen, Patrick R. Hof, Constantin Bouras, Nigel J. Cairns, Julie A. Schneider, Gregory A. Jicha
Publikováno v:
Journal of Neuropathology and Experimental Neurology, Vol. 71, No 5 (2012) pp. 362-81
Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6f1ef3ab261350c0ad4ec577aacd23
https://archive-ouverte.unige.ch/unige:29901
https://archive-ouverte.unige.ch/unige:29901
Autor:
Panteleimon Giannakopoulos, Eniko Veronika Kovari, Patrick R. Hof, François Herrmann, Constantin Bouras
Publikováno v:
Stroke, vol. 40, no. 3, pp. 983-986
Stroke, Vol. 40, No 3 (2009) pp. 983-6
Stroke, Vol. 40, No 3 (2009) pp. 983-6
Background and Purpose— Most of the neuropathological studies in brain aging were based on the assumption of a symmetrical right–left hemisphere distribution of both Alzheimer disease and vascular pathology. To explore the impact of asymmetrical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad7c6897643aa92130a55e51cd18f45
https://serval.unil.ch/notice/serval:BIB_C16178C68A86
https://serval.unil.ch/notice/serval:BIB_C16178C68A86
Publikováno v:
Brain, Vol. 130, No Pt 11 (2007) pp. 2830-2836
Brain, vol. 130, no. 11, pp. 2830-2836
Brain, vol. 130, no. 11, pp. 2830-2836
To explore the pathological substrates of mixed dementia, we performed a detailed analysis of lacunar and microvascular pathology in 156 autopsied, elderly individuals with various degrees of Alzheimer's disease (AD) pathology. Cognitive status was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3765ba941b24135a1414ce68871ce56b
https://archive-ouverte.unige.ch/unige:28096
https://archive-ouverte.unige.ch/unige:28096
Autor:
Jean-Pierre Brion
Publikováno v:
Journal of Alzheimer's disease, 9 (3 Suppl
Jean-Pierre Brion
Scopus-Elsevier
Jean-Pierre Brion
Scopus-Elsevier
Neurofibrillary tangles are one of the neuropathological hallmark of Alzheimer's disease, described early as part of the pathological criteria of the disease. Ultrastuctural studies in the sixties showed their unusual features but their molecular com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b85d6984afa75ba7ff9f602d1d0264
https://pubmed.ncbi.nlm.nih.gov/16914857
https://pubmed.ncbi.nlm.nih.gov/16914857
Autor:
Eniko Veronika Kovari, Patrick R. Hof, Armin von Gunten, Gabriel Gold, Panteleimon Giannakopoulos, Anouk Imhof, Constantin Bouras
Publikováno v:
Acta Neuropathologica, Vol. 113, No 1 (2007) pp. 1-12
The progressive development of Alzheimer disease (AD)-related lesions, such as neurofibrillary tangles (NFT), amyloid deposits and synaptic loss, and the occurrence of microvascular and small macrovascular pathology within the cerebral cortex are con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675bcdaba32dc9ae6455d8f7828c3957
https://pubmed.ncbi.nlm.nih.gov/17036244
https://pubmed.ncbi.nlm.nih.gov/17036244
Publikováno v:
Neuropathology and Applied Neurobiology, Vol. 30, No 1 (2004) pp. 57-69
The molecular bases of late-onset and sporadic Alzheimer's disease (AD) still have to be unraveled. Among putative candidates for molecular variations in AD, we propose LMO4 protein, a transcription regulator, involved in multiple protein complexes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5c4bdd5ba71e605b89a7fcf1c6115537
https://archive-ouverte.unige.ch/unige:26609
https://archive-ouverte.unige.ch/unige:26609
Autor:
Karelle Leroy, Michèle Authelet, Jean Pierre Brion, Jean-Noël Octave, Simon Lovestone, Gunter Tremp, Nicole Touchet, R Dayanandan, Laurent Pradier, Brian H. Anderton
Publikováno v:
Biochemical Society Symposia (67
Europe PubMed Central
Europe PubMed Central
Neurofibrillary tangles (NFTs) are a characteristic neuropathological lesion of Alzheimer's disease (AD). They are composed of a highly-phosphorylated form of the microtubule-associated protein tau. We are investigating the relationship between NFTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c5b810ae7d9a2502bcd1f569a1bb90
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/63492
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/63492