Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Neurodegenerative Diseases - metabolism"'
Publikováno v:
Scientific Reports. 13(1)
Loss of neurons in chronic neurodegenerative diseases may occur over a period of many years. Once initiated, neuronal cell death is accompanied by distinct phenotypic changes including cell shrinkage, neurite retraction, mitochondrial fragmentation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________83::fc9c3f89188a745d74ea6d03f9a8cc65
https://cris.maastrichtuniversity.nl/en/publications/7f25a50c-cc39-4093-8d34-e2230aa0d042
https://cris.maastrichtuniversity.nl/en/publications/7f25a50c-cc39-4093-8d34-e2230aa0d042
Autor:
Breedge Callaghan, Karen Lester, Brian Lane, Xiaochen Fan, Katarzyna Goljanek-Whysall, David A. Simpson, Carl Sheridan, Colin E. Willoughby
Publikováno v:
Callaghan, B, Lester, K, Lane, B, Fan, X, Goljanek-Whysall, K, Simpson, D A, Sheridan, C & Willoughby, C E 2022, ' Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2 ', Scientific Reports, vol. 12, 9564 . https://doi.org/10.1038/s41598-022-13573-8
Glaucoma is a complex neurodegenerative disease resulting in progressive optic neuropathy and is a leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG) is the predominant form affecting 65.5 million people globally. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c691b7a5a5a1f499b291fbdc0dc9921
https://doi.org/10.21203/rs.3.rs-955522/v1
https://doi.org/10.21203/rs.3.rs-955522/v1
Autor:
Christian Ottmann, Alba Gigante, M. Bartel, J. Briels, Carsten Schmuck, Daniel Hoffmann, Jean-Noël Grad
Publikováno v:
Chemical Communications, ChemComm, 55(1), 111-114. Royal Society of Chemistry
We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321f62f63b901897c5431e36a82bd9e0
https://doi.org/10.1039/c8cc07946c
https://doi.org/10.1039/c8cc07946c
Publikováno v:
Cells, Vol 9, Iss 1590, p 1590 (2020)
Cells
Cells
Non-muscle myosin 2A (NM2A) is a motor cytoskeletal enzyme with crucial importance from the early stages of development until adulthood. Due to its capacity to convert chemical energy into force, NM2A powers the contraction of the actomyosin cytoskel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfb2effb428aed032bf8004e2812d38
https://hdl.handle.net/10216/143490
https://hdl.handle.net/10216/143490
Homocysteine (hcy) is an amino acid that contains sulfur species. In healthy individuals, plasma hcy levels are low. The aim of this study was to investigate the potential neurotoxic effects of hcy and sulfite (sft) molecules alone and in their combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d406bdbb0dfbb609301be0cce3b08fd
Publikováno v:
Nilsson, M, Gjedde, A, Brock, B, Gejl, M & Rungby, J 2018, ' The effects of incretin hormones on cerebral glucose metabolism in health and disease ', Neuropharmacology, vol. 136, no. Pt B, pp. 243-250 . https://doi.org/10.1016/j.neuropharm.2017.12.031
Nilsson, M, Gjedde, A, Brock, B, Gejl, M & Rungby, J 2018, ' The effects of incretin hormones on cerebral glucose metabolism in health and disease ', Neuropharmacology, vol. 136, no. Part B, pp. 243-250 . https://doi.org/10.1016/j.neuropharm.2017.12.031
Nilsson, M, Gjedde, A, Brock, B, Gejl, M & Rungby, J 2018, ' The effects of incretin hormones on cerebral glucose metabolism in health and disease ', Neuropharmacology, vol. 136, no. Part B, pp. 243-250 . https://doi.org/10.1016/j.neuropharm.2017.12.031
Incretin hormones, notably glucagon-like peptide-1 (GLP-1), are gluco-regulatory hormones with pleiotropic effects also in the central nervous system. Apart from a local production of GLP-1, systemic administration of the hormone has been shown to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8075c4042e342e8162afb9e111e500
https://pure.au.dk/portal/da/publications/the-effects-of-incretin-hormones-on-cerebral-glucose-metabolism-in-health-and-disease(58e0611a-9e14-42ab-81ca-660fa606777d).html
https://pure.au.dk/portal/da/publications/the-effects-of-incretin-hormones-on-cerebral-glucose-metabolism-in-health-and-disease(58e0611a-9e14-42ab-81ca-660fa606777d).html
Publikováno v:
Experimental Dermatology
Experimental Dermatology, Wiley, 2018, 27 (8), pp.852-858. ⟨10.1111/exd.13684⟩
Experimental Dermatology, Wiley, 2018, 27 (8), pp.852-858. ⟨10.1111/exd.13684⟩
International audience; Deimination or citrullination is a post-translational modification catalysed by a family of calcium-dependent enzymes called peptidylarginine deiminases (PADs). It corresponds to the transformation of arginine residues within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3daf24eddf486c89abbd25e731b97a9b
https://pubmed.ncbi.nlm.nih.gov/29756256
https://pubmed.ncbi.nlm.nih.gov/29756256
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease; Vol 1802
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2009, 1802 (1), pp.151. ⟨10.1016/j.bbadis.2009.08.001⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2010, 1802 (1), pp.151-61. ⟨10.1016/j.bbadis.2009.08.001⟩
BBA-Biochimica et Biophysica Acta, 2010, 1802 (1), pp.151-61. ⟨10.1016/j.bbadis.2009.08.001⟩
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2009, 1802 (1), pp.151. ⟨10.1016/j.bbadis.2009.08.001⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2010, 1802 (1), pp.151-61. ⟨10.1016/j.bbadis.2009.08.001⟩
BBA-Biochimica et Biophysica Acta, 2010, 1802 (1), pp.151-61. ⟨10.1016/j.bbadis.2009.08.001⟩
International audience; Mitochondrial dysfunctions have been implicated in the cellular processes underlying several neurodegenerative disorders affecting the basal ganglia. These include Huntington's chorea and Parkinson's disease, two highly debili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cff29678effa65637604fb0efb2c08b
Autor:
Rawien Balesar, Paul J. Lucassen, D. P. Noske, J. Wouda, Dick F. Swaab, A. A. Sluiter, Johannes C. Baayen, A.-M. Van Dam, R. W. H. Verwer, C. M. F. Dirven
Publikováno v:
Brain, 130, 3321-3335. Oxford University Press
Verwer, R W H, Sluiter, A A, Balesar, R A, Baayen, J C, Noske, D P, Dirven, C M F, Wouda, J, van Dam, A M, Lucassen, P J & Swaab, D F 2007, ' Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin ', Brain, vol. 130, no. Pt 12, pp. 3321-35 . https://doi.org/10.1093/brain/awm264
Brain, 130(Pt 12), 3321-35. Oxford University Press
Verwer, R W H, Sluiter, A A, Balesar, R A, Baayen, J C, Noske, D P, Dirven, C M F, Wouda, J, van Dam, A M, Lucassen, P J & Swaab, D F 2007, ' Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin ', Brain, vol. 130, no. Pt 12, pp. 3321-35 . https://doi.org/10.1093/brain/awm264
Brain, 130(Pt 12), 3321-35. Oxford University Press
Doublecortin (DCX) is a microtubule-associated protein expressed by migrating neuroblasts and is considered to be a reliable marker of neurogenesis. DCX has been used to study the relation between neurogenesis in adult human brain and neurological an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef2da0b92653d43f403cafc71ac3a6d
https://doi.org/10.1093/brain/awm264
https://doi.org/10.1093/brain/awm264
Autor:
Karl-Heinz Krause
Publikováno v:
Experimental Gerontology, Vol. 42, No 4 (2007) pp. 256-262
Reactive oxygen species (ROS), often also referred to as free radicals, play an important role in aging. It is widely assumed that mitochondria are the predominant source of ROS relevant for the aging process. In this hypothesis article, we suggest t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9421786eceefad5f7bf56789e87dfac9
https://doi.org/10.1016/j.exger.2006.10.011
https://doi.org/10.1016/j.exger.2006.10.011