Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity

Autor: Philipp Koch, Christa E. Müller, Julius A. Steinbeck, Ruven Wilkens, Philip D. Gregory, Daniel Poppe, Marion Schneider, Julia Ladewig, Andreas Reik, David Paschon, Allison Tam, Jonas Doerr, Oliver Brüstle

Publikováno v: Stem Cells Translational Medicine

As a powerful regulator of cellular homeostasis and metabolism, adenosine is involved in diverse neurological processes including pain, cognition, and memory. Altered adenosine homeostasis has also been associated with several diseases such as depres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9130ac32fa7926737d8d4cf68800fa
https://doi.org/10.1002/sctm.16-0272

Embryonic Stem Cell‐Derived Mesenchymal Stem Cells (MSCs) Have a Superior Neuroprotective Capacity Over Fetal MSCs in the Hypoxic‐Ischemic Mouse Brain

Autor: Pascale V. Guillot, Filipa Vlahova, Anna Maria Ranzoni, Pierre Gressens, Kate Dowding, Kwan-Leong Hau, Henrik Hagberg, Kate E. Hawkins, Mariya Hristova, Donald Peebles, Michelangelo Corcelli, Avina Hunjan, Paolo De Coppi

Publikováno v: Stem Cells Translational Medicine
Hawkins, K E, Corcelli, M, Dowding, K, Ranzoni, A M, Vlahova, F, Hau, K-L, Hunjan, A, Peebles, D, Gressens, P, Hagberg, H, de Coppi, P, Hristova, M & Guillot, P V 2018, ' Embryonic Stem Cell-Derived Mesenchymal Stem Cells (MSCs) Have a Superior Neuroprotective Capacity Over Fetal MSCs in the Hypoxic-Ischemic Mouse Brain ', Stem cells translational medicine, vol. 7 . https://doi.org/10.1002/sctm.17-0260

Human mesenchymal stem cells (MSCs) have huge potential for regenerative medicine. In particular, the use of pluripotent stem cell-derived mesenchymal stem cells (PSC-MSCs) overcomes the hurdle of replicative senescence associated with the in vitro e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102dfc03b22dc61410f937c3f5d6402
http://europepmc.org/articles/PMC5905231

Concise Review: Extracellular Vesicles Overcoming Limitations of Cell Therapies in Ischemic Stroke

Autor: Bernd Giebel, Dirk M. Hermann, Mathias Bähr, Thorsten R. Doeppner

Publikováno v: Stem Cells Translational Medicine

Despite recent advances in stroke therapy, current therapeutic concepts are still limited. Thus, additional therapeutic strategies are in order. In this sense, the transplantation of stem cells has appeared to be an attractive adjuvant tool to help b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3106abacd8512b2c7e3003599e592a
https://doi.org/10.1002/sctm.17-0081

Immature Midbrain Dopaminergic Neurons Derived from Floor‐Plate Method Improve Cell Transplantation Therapy Efficacy for Parkinson's Disease

Autor: Shaoping Xie, Shunhui Wei, Mei-Chih Liao, Allen Chen, Shaul Reuveny, Steve Oh, Walter Hunziker, Li Zeng, Zhi Dong Zhou, Lifeng Qiu, Eng-King Tan

Publikováno v: Stem Cells Translational Medicine

Recent reports have indicated human embryonic stem cells-derived midbrain dopamine (mDA) neurons as proper cell resources for use in Parkinson's disease (PD) therapy. Nevertheless, no detailed and systematic study has been conducted to identify which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6218b361a3e046fe126dbd90f25ee11f
http://europepmc.org/articles/PMC5689771

Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells

Autor: Andrew, Osborne, Julie, Sanderson, Keith R, Martin

Publikováno v: Stem Cells (Dayton, Ohio)

Optic neuropathies such as glaucoma occur when retinal ganglion cells (RGCs) in the eye are injured. Strong evidence suggests mesenchymal stem cells (MSCs) could be a potential therapy to protect RGCs; however, little is known regarding their effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d5935750fd0cd4be13aab728bbdfb24
https://pubmed.ncbi.nlm.nih.gov/29044808