Zobrazeno 1 - 10
of 1 713
pro vyhledávání: '"Neurexin"'
Autor:
Longsheng Xu, Shang Zheng, Liping Chen, Lei Yang, Shuyao Zhang, Beibei Liu, Kangli Shen, Qinli Feng, Qinghe Zhou, Ming Yao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102200- (2024)
Cancer-induced bone pain (CIBP) significantly impacts the quality of life and survival of patients with advanced cancer. Despite the established role of neurexins in synaptic structure and function, their involvement in sensory processing during inju
Externí odkaz:
https://doaj.org/article/f185a962fe494e708e7e91ccb0c177ec
Autor:
Johannes Brockhaus, Iris Kahl, Mohiuddin Ahmad, Daniele Repetto, Carsten Reissner, Markus Missler
Publikováno v:
Cells, Vol 13, Iss 11, p 981 (2024)
Presynaptic Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) is a key signal for synaptic vesicle release. Synaptic neurexins can partially determine the strength of transmission by regulating VGCCs. However, it is unknown whether neurexins mo
Externí odkaz:
https://doaj.org/article/aa43ca8fab874f8fa14b7d6695f9303a
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Postmortem studies in schizophrenia consistently show reduced dendritic spines in the cerebral cortex but the mechanistic underpinnings of these deficits remain unknown. Recent genome-wide association studies and exome sequencing
Externí odkaz:
https://doaj.org/article/c0d3e77eda4647b98bb37616b0ddb413
Autor:
Artemis Koumoundourou, Märt Rannap, Elodie De Bruyckere, Sigrun Nestel, Carsten Reissner, Alexei V Egorov, Pengtao Liu, Markus Missler, Bernd Heimrich, Andreas Draguhn, Stefan Britsch
Publikováno v:
eLife, Vol 12 (2024)
The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and functional i
Externí odkaz:
https://doaj.org/article/0a92cb2e40194094ae4c489313d0590f
Autor:
Gan Guangming, Chen Mei, Yu Qinfeng, Gao Xiang, Zhang Chenchen, Sheng Qingyuan, Xie Wei, Geng Junhua
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The Drosophila larval neuromuscular junction (NMJ) is a well-known model system and is often used to study synapse development. Here, we show synaptic degeneration at NMJ boutons, primarily based on transmission electron microscopy (TEM) studies. Whe
Externí odkaz:
https://doaj.org/article/a8f5b76d063f43cc93f5832c0c4f337e
Autor:
Xing Liu, Fuzhou Hua, Danying Yang, Yue Lin, Lieliang Zhang, Jun Ying, Hongguang Sheng, Xifeng Wang
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Neuroligins are postsynaptic cell adhesion molecules that are relevant to many neurodevelopmental disorders. They are differentially enriched at the postsynapse and interact with their presynaptic ligands, neurexins, whose differential bindi
Externí odkaz:
https://doaj.org/article/3bc30383c1f94703b713b3560c83baf2
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
A variety of proteins can be encoded by a single gene via the differential splicing of exons. In neurons this form of alternative splicing can be controlled by activity-dependent calcium signaling, leading to the properties of proteins being altered,
Externí odkaz:
https://doaj.org/article/0df61864ff4b4171b46db4e31cfd2de2
Publikováno v:
Water Biology and Security, Vol 2, Iss 3, Pp 100186- (2023)
As a copper (Cu) transport ATPase, ATP7A plays an important role in maintaining Cu homeostasis in the body, but the developmental and physiological roles of atp7a in zebrafish embryogenesis are rarely studied. In this study, normal morphological phen
Externí odkaz:
https://doaj.org/article/85ff397da3244429802cbffe13676f7b
Autor:
Amy Cheung, Kotaro Konno, Yuka Imamura, Aya Matsui, Manabu Abe, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Masahiko Watanabe, Kensuke Futai
Publikováno v:
eLife, Vol 12 (2023)
Extensive serotonin (5-hydroxytryptamine, 5-HT) innervation throughout the brain corroborates 5-HT’s modulatory role in numerous cognitive activities. Volume transmission is the major mode for 5-HT transmission but mechanisms underlying 5-HT signal
Externí odkaz:
https://doaj.org/article/4868a911a672491985c4f12c4908558e
Autor:
Sahar Avazzadeh, Leo R. Quinlan, Jamie Reilly, Katya McDonagh, Amirhossein Jalali, Yanqin Wang, Veronica McInerney, Janusz Krawczyk, Yicheng Ding, Jacqueline Fitzgerald, Matthew O’Sullivan, Eva B. Forman, Sally A. Lynch, Sean Ennis, Niamh Feerick, Richard Reilly, Weidong Li, Xu Shen, Guangming Yang, Yin Lu, Hilde Peeters, Peter Dockery, Timothy O’Brien, Sanbing Shen, Louise Gallagher
Publikováno v:
BMC Neuroscience, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, and the latter is associated with excessive neuron
Externí odkaz:
https://doaj.org/article/8c2eb31274174d058bbfb6103c3a9172