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LB19. Intramuscular therapeutic immunization targeting RelMtb/MIP-3 induces immune signatures associated with better TB control in vivo compared to

Autor: Karanika, Styliani, Gordy, James, Neupane, Pranita, Markham, Richard, Karakousis, Petros

Publikováno v: Open Forum Infectious Diseases

Background Tuberculosis (TB) is one of the leading causes of death from a single infectious agent worldwide. The lengthy treatment regimen reflects the unique ability of a subpopulation of “persister” bacteria to remain in a nonreplicating state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2504098563aa4f6b32a32282fff9b459
https://doi.org/10.1093/ofid/ofab466.1655

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Pharmacological inhibition of macrophage triglyceride biosynthesis pathways does not improve Mycobacterium tuberculosis control in infected mice.

Autor: Ruelas Castillo J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Guerrini V; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States., Quijada D; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Karanika S; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Neupane P; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Urbanowski ME; The Internal Medicine Residency Program of the National Capital Consortium at Walter Reed National Military Medical Center. Bethesda, MD, United States., Shenkoya B; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD, United States., Harris H; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Garcia A; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Yilma A; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Annunziata H; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Khan R; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States., Gopalakrishnan M; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD, United States., Gennaro ML; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States., Karakousis PC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model.

Autor: Castillo JR; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Neupane P; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Karanika S; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Krug S; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA., Quijada D; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Garcia A; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ayeh S; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yilma A; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Costa DL; Departmento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Fotouhi N; TB Alliance, New York, NY, USA., Serbina N; TB Alliance, New York, NY, USA., Karakousis PC; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 13. Date of Electronic Publication: 2023 Nov 13.