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Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma.

Autor: Silver DJ; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Roversi GA; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Bithi N; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Wang SZ; Medical Scientist Training Program, Case Western Reserve University, Cleveland, United States of America., Troike KM; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Neumann CK; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Ahuja GK; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Reizes O; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Brown JM; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Hine C; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America., Lathia JD; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, United States of America.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Jul 13. Date of Electronic Publication: 2021 Jul 13.

Obesity-linked suppression of membrane-bound O -acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

Autor: Helsley RN; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States.; Department of Internal Medicine, University of Cincinnati, Cincinnati, United States., Varadharajan V; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Brown AL; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Gromovsky AD; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Schugar RC; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Ramachandiran I; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Fung K; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Kabbany MN; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Banerjee R; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Neumann CK; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Finney C; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Pathak P; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Orabi D; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Osborn LJ; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Massey W; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Zhang R; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Kadam A; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Sansbury BE; Center for Experimental Therapeutics & Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States., Pan C; Department of Medicine, University of California, Los Angeles, Los Angeles, United States.; Department of Microbiology, University of California, Los Angeles, Los Angeles, United States.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, United States., Sacks J; Department of Pathobiology, Cleveland Clinic, Cleveland, United States., Lee RG; Cardiovascular Group, Antisense Drug Discovery, Ionis Pharmaceuticals, Inc, Carlsbad, United States., Crooke RM; Cardiovascular Group, Antisense Drug Discovery, Ionis Pharmaceuticals, Inc, Carlsbad, United States., Graham MJ; Cardiovascular Group, Antisense Drug Discovery, Ionis Pharmaceuticals, Inc, Carlsbad, United States., Lemieux ME; Bioinfo, Plantagenet, Canada., Gogonea V; Department of Chemistry, Cleveland State University, Cleveland, United States., Kirwan JP; Department of Pathobiology, Cleveland Clinic, Cleveland, United States., Allende DS; Department of Anatomical Pathology, Cleveland Clinic, Cleveland, United States., Civelek M; Department of Biomedical Engineering, University of Virginia, Charlottesville, United States., Fox PL; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States., Rudel LL; Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, United States., Lusis AJ; Department of Medicine, University of California, Los Angeles, Los Angeles, United States.; Department of Microbiology, University of California, Los Angeles, Los Angeles, United States.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, United States., Spite M; Center for Experimental Therapeutics & Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States., Brown JM; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States.

Publikováno v: ELife [Elife] 2019 Oct 17; Vol. 8. Date of Electronic Publication: 2019 Oct 17.