Zobrazeno 1 - 10
of 1 218
pro vyhledávání: '"Neuhoff, P."'
Transitioning to a net-zero economy requires a nuanced understanding of homeowners decision-making pathways when considering the adoption of Low Carbon Technologies (LCTs). These LCTs present both personal and collective benefits, with positive perce
Externí odkaz:
http://arxiv.org/abs/2308.10104
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1513-1527 (2024)
Abstract OATP1B facilitates the uptake of xenobiotics into hepatocytes and is a prominent target for drug–drug interactions (DDIs). Reduced systemic exposure of OATP1B substrates has been reported following multiple‐dose rifampicin; one explanati
Externí odkaz:
https://doaj.org/article/5334c41546ee4ed98d6b56aaabccd6a8
Autor:
Liam Curry, Sarah Alrubia, Frederic Y. Bois, Ruth Clayton, Eman El‐Khateeb, Trevor N. Johnson, Muhammad Faisal, Sibylle Neuhoff, Kris Wragg, Amin Rostami‐Hodjegan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1429-1447 (2024)
Abstract The Simcyp Simulator is a software platform widely used in the pharmaceutical industry to conduct stochastic physiologically‐based pharmacokinetic (PBPK) modeling. This approach has the advantage of combining routinely generated in vitro d
Externí odkaz:
https://doaj.org/article/769597f4e2694f17b0ec0f0ede76ea59
Assessment of image quality and impact of deep learning-based software in non-contrast head CT scans
Autor:
Denise Bos, Aydin Demircioğlu, Julia Neuhoff, Johannes Haubold, Sebastian Zensen, Marcel K. Opitz, Marcel A. Drews, Yan Li, Hanna Styczen, Michael Forsting, Kai Nassenstein
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract In this retrospective study, we aimed to assess the objective and subjective image quality of different reconstruction techniques and a deep learning-based software on non-contrast head computed tomography (CT) images. In total, 152 adult he
Externí odkaz:
https://doaj.org/article/ee83d3ee26bf46f1bbc8d5fe19deb44e
Publikováno v:
Frontiers in Surgery, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/f3daf4c0a0d448c2b5d8cbf9099e917c
Autor:
Ariel Robbins, Hazen Hildebolt, Michael Neuhoff, Peter Beshay, Jessica O. Winter, Carlos E. Castro, Ralf Bundschuh, Michael G. Poirier
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Biomolecular systems are dependent on a complex interplay of forces. Modern force spectroscopy techniques provide means of interrogating these forces, but they are not optimized for studies in constrained environments as they require attachm
Externí odkaz:
https://doaj.org/article/9d8b1719f3fd49ac8789b779e7d5820d
Autor:
Andreas Kramer, Santhosh G. Thavarajasingam, Jonathan Neuhoff, Hariharan Subbiah Ponniah, Daniele S. C. Ramsay, Andreas K. Demetriades, Benjamin M. Davies, Ehab Shiban, Florian Ringel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Pyogenic spondylodiscitis presents significant diagnostic and therapeutic challenges. In Germany, a comprehensive understanding of its epidemiology and inpatient management outcomes is limited, hindering the optimisation of therapeutic strat
Externí odkaz:
https://doaj.org/article/eff4c56b0a6e44ce8dc7d3dfe8ba5287
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1284 (2024)
Background/Objectives: Plasma levels of 4β-hydroxycholesterol (4β-OHC), a CYP3A-specific metabolite of cholesterol, are elevated after administration of CYP3A inducers like rifampicin and carbamazepine. To simulate such plasma 4β-OHC increase, we
Externí odkaz:
https://doaj.org/article/196f7ff56933489ebead894d0428330a
Autor:
Santhosh G. Thavarajasingam, Kalyan V. Vemulapalli, Sajeenth Vishnu K., Hariharan Subbiah Ponniah, Alexander Sanchez-Maroto Vogel, Robert Vardanyan, Jonathan Neuhoff, Andreas Kramer, Ehab Shiban, Florian Ringel, Andreas K. Demetriades, Benjamin M. Davies
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-27 (2023)
Abstract Spondylodiscitis is the commonest spine infection, and pyogenic spondylodiscitis is the most common subtype. Whilst antibiotic therapy is the mainstay of treatment, some advocate that early surgery can improve mortality, relapse rates, and l
Externí odkaz:
https://doaj.org/article/67bcf0d4bae34fa2a354c43be23050a2
Autor:
William A. Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D. Guy, Manal F. Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Hepatology Communications, Vol 8, Iss 3 (2024)
Background:. NAFLD is highly prevalent with limited treatment options. Bile acids (BAs) increase in the systemic circulation and liver during NAFLD progression. Changes in plasma membrane localization and zonal distribution of BA transporters can inf
Externí odkaz:
https://doaj.org/article/aac573e3c0734319af4532863a1f9a55