RGS4 negatively modulates Nociceptin/Orphanin FQ opioid receptor signaling: implication for L-Dopa induced dyskinesia

Autor: Pisanò, C. A., Mercatelli, D., Mazzocchi, M., Brugnoli, A., Morella, I., Fasano, S., Zaveri, N. T., Brambilla, R., O'Keeffe, G. W., Neubig, R. R., Morari, M.

Background and purpose\ud \ud Regulator of G-protein signal 4 (RGS4) is a signal transduction protein that accelerates intrinsic GTPase activity of Gαi/o and Gαq subunits, suppressing GPCR signaling. Here we investigate whether RGS4 modulates nocic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::8addfefcaae3bd765da81a4620c180c6
https://orca.cardiff.ac.uk/id/eprint/145435/1/bph.15730.pdf

The state of GPCR research in 2004

Autor: Bartfai, T., Benovic, J.L., Bockaert, J., Bond, R.A., Bouvier, M., Christopoulos, A., Civelli, O., Devi, L.A., George, S.R., Inui, A., Kobilka, B., Leurs, R., Neubig, R., Pin, J.P., Quirion, R., Roques, B.P., Sakmar, T.P., Seifert, R., Stenkamp, R.E., Strange, P.G.

Publikováno v: Bartfai, T, Benovic, J L, Bockaert, J, Bond, R A, Bouvier, M, Christopoulos, A, Civelli, O, Devi, L A, George, S R, Inui, A, Kobilka, B, Leurs, R, Neubig, R, Pin, J P, Quirion, R, Roques, B P, Sakmar, T P, Seifert, R, Stenkamp, R E & Strange, P G 2004, ' The state of GPCR research in 2004 ', Nature Reviews Drug Discovery, vol. 3, no. 7, pp. 574-626 . https://doi.org/10.1038/nrd1458
Nature Reviews Drug Discovery, 3(7), 574-626. Nature Publishing Group

List of questions G-protein-coupled receptors (GPCRs) comprise the largest single class of cell-surface receptors, and have a history of being excellent therapeutic targets for a number of diseases. Yet several fundamental questions remain regarding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15599174a7f720e8551508d857b37150
https://research.vu.nl/en/publications/5f3edb59-aa3b-4e43-8d42-bbe65a0b6317

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Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors

Autor: Michel, M. C., Regan, J. W., Gerhardt, M. A., Neubig, R. R., Insel, P. A., Motulsky, H. J.

Publikováno v: Molecular pharmacology, 37(1), 65-68. American Society for Pharmacology and Experimental Therapeutics

We have recently demonstrated that the alpha 2-adrenergic radioligand [3H]idazoxan also labels additional sites that do not recognize catecholamines but bind with high affinity several chemically distinct drugs previously assumed to be highly selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::8ad334ae58cc37a5eb29eb921741365d
https://pure.amc.nl/en/publications/nonadrenergic-3hidazoxan-binding-sites-are-physically-distinct-from-alpha-2adrenergic-receptors(732b857d-796e-4898-a72a-26761a5d0fb3).html

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