Zobrazeno 1 - 10
of 1 617
pro vyhledávání: '"Network biology"'
Publikováno v:
The Microbe, Vol 5, Iss , Pp 100175- (2024)
Klebsiella pneumoniae (K. pneumoniae) is a pathogen that has been identified as the leading cause of pneumonia and septicemia worldwide, compounded by its multi-drug resistant nature. Computational and bioinformatics approaches are yet understudied i
Externí odkaz:
https://doaj.org/article/25853154970c469f9974520eb09ce5c1
Autor:
Katharina F. Heil, Anze Zupanic, Chris T. Evelo, Carole Goble, Kristel Van Steen, Tadeja Rezen, Hans V Westerhoff, Rahuman S. Malik Sheriff, Maria Suarez Diez, Henning Hermjakob, Marco Pagni, Damjana Rozman, Barbara Szomolay, Miguel Rocha, Jasper Koehorst, Alexey Kolodkin, Victoria Dominguez Del Angel, David Šafránek, Dirk Fey, Ilja Arts, Rui Benfeitas, Vitor Martins dos Santos, Mihail Anton, Marek Ostaszewski, Ulrike Wittig, John M. Hancock, Brane Leskošek, Katherine Wolstencroft, Martin Golebiewski, Wolfgang Müller, Polonca Ferk, Kristina Gruden, William T. Scott, Elena Domínguez-Romero, Martina Kutmon, Maria I. Klapa, Sébastien Moretti, Pascal Kahlem
Publikováno v:
F1000Research, Vol 11 (2024)
In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Community beli
Externí odkaz:
https://doaj.org/article/231bbdc173f041d7b339528a06d2b5e4
Publikováno v:
Network Biology, Vol 13, Iss 4, Pp 137-154 (2023)
Wolbachia are gram-negative endosymbiotic bacteria residing in the nematode host Brugia malayi that causes lymphatic filariasis in humans. Wolbachia settle in the host environment for their survival, growth and reproduction by maintaining an obligate
Externí odkaz:
https://doaj.org/article/52e6148b99d74a0a9c0287529a0689ad
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8917 (2024)
In the post-COVID-19 era, treatment options for potential SARS-CoV-2 outbreaks remain limited. An increased incidence of central nervous system (CNS) disorders has been observed in long-term COVID-19 patients. Understanding the shared molecular mecha
Externí odkaz:
https://doaj.org/article/98a35d3a77c8453b828fac6886093025
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Background: Understanding how cells and tissues respond to stress factors and perturbations during disease processes is crucial for developing effective prevention, diagnosis, and treatment strategies. Single-cell RNA sequencing (scRNA-seq) enables h
Externí odkaz:
https://doaj.org/article/cd6687efed8844778be82dc12fd002cb
Autor:
Akshayata Naidu, Sajitha Lulu S.
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionEnteric infections are a major cause of under-5 (age) mortality in low/middle-income countries. Although vaccines against these infections have already been licensed, unwavering efforts are required to boost suboptimalefficacy and effecti
Externí odkaz:
https://doaj.org/article/ea6ef85e98a04d8abd70f22d05c18643
Autor:
Danishuddin, Md Azizul Haque, Md. Zubbair Malik, Rakesh Arya, Pooja Singh, Jeong-Sang Lee, Jong-Joo Kim, Keun-Woo Lee, Tae-Sung Jung
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 921 (2024)
Head and neck cancer ranks as the sixth-most common malignancy worldwide, characterized by high mortality and recurrence rates. Research studies indicate that molecular diagnostics play a crucial role in the early detection and prognostic evaluation
Externí odkaz:
https://doaj.org/article/90bec09d0a004b939598bc5eae2b1f0a
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Computational models of cell signaling networks are extremely useful tools for the exploration of underlying system behavior and prediction of response to various perturbations. By representing signaling cascades as executable Boo
Externí odkaz:
https://doaj.org/article/0db139fe0ff24c85bd66b8e9e043e574
Autor:
Layla Hosseini-Gerami, Ixavier Alonzo Higgins, David A. Collier, Emma Laing, David Evans, Howard Broughton, Andreas Bender
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Background Elucidating compound mechanism of action (MoA) is beneficial to drug discovery, but in practice often represents a significant challenge. Causal Reasoning approaches aim to address this situation by inferring dysregulated signalli
Externí odkaz:
https://doaj.org/article/0d25a68bc88b4eda8c60ccb5c1863ac9
Autor:
Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David C. Airey, James Scherschel, Sarubini Kananathan, Brian J. Eastwood, Suchira Bose, David A. Collier, Emma Laing, David Evans, Howard Broughton, Andreas Bender
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background A key histopathological hallmark of Alzheimer’s disease (AD) is the presence of neurofibrillary tangles of aggregated microtubule-associated protein tau in neurons. Anle138b is a small molecule which has previously shown efficac
Externí odkaz:
https://doaj.org/article/5f63ecb9bfa34970acca9a7c9e02d8ec