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KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Autor: Schumann, G, Liu, C, O'Reilly, P, Gao, H, Song, P, Xu, B, Ruggeri, B, Amin, N, Jia, T, Preis, S, Lepe, MS, Akira, S, Barbieri, C, Baumeister, S, Cauchi, S, Clarke, TK, Enroth, S, Fischer, K, Hällfors, J, Harris, SE, Hieber, S, Hofer, E, Hottenga, JJ, Johansson, Å, Joshi, PK, Kaartinen, N, Laitinen, J, Lemaitre, R, Loukola, A, Luan, J, Lyytikäinen, LP, Mangino, M, Manichaikul, A, Mbarek, H, Milaneschi, Y, Moayyeri, A, Mukamal, K, Nelson, C, Nettleton, J, Partinen, E, Rawal, R, Robino, A, Rose, L, Sala, C, Satoh, T, Schmidt, R, Schraut, K, Scott, R, Smith, AV, Starr, JM, Teumer, A, Trompet, S, Uitterlinden, AG, Venturini, C, Vergnaud, AC, Verweij, N, Vitart, V, Vuckovic, D, Wedenoja, J, Yengo, L, Yu, B, Zhang, W, Zhao, JH, Boomsma, DI, Chambers, J, Chasman, DI, Daniela, T, De Geus, E, Deary, I, Eriksson, JG, Esko, T, Eulenburg, V

Publikováno v: Schumann, G; Liu, C; O'Reilly, P; Gao, H; Song, P; Xu, B; et al.(2016). KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences of the United States of America, 113(50), 14372-14377. doi: 10.1073/pnas.1611243113. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1499q8k6

Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::eb624e2ddf152cff3c38269fd2ab6670
http://www.escholarship.org/uc/item/1499q8k6

Dietary fatty acids: is it time to change the recommendations

Autor: Nettleton, J. A., Lovegrove, J. A., Mensink, R. P., Schwab, U.

Limiting the saturated fatty acid (SAFA) consumption forms the basis of dietary fat recommendations for heart health, despite several meta-analyses demonstrating no link be- tween dietary SAFA and the risk of cardiovascular disease (CVD). Three exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::973ee1b709779d9e31b4395bd7066399
https://centaur.reading.ac.uk/65931/7/446865.pdf

Metabolomics and Incident Hypertension Among Blacks: The Atherosclerosis Risk in Communities Study

Autor: Boerwinkle, E., Mosley, T. H., Alexander, D., Nettleton, J. A., Heiss, G., Yu, B., Zheng, Y.

Development of hypertension is influenced by genes, environmental effects and their interactions, and the human metabolome is a measurable manifestation of gene-environment interaction. We explored the metabolomic antecedents of developing incident h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5f962b115888c8be976f95f2d6b2cc4

Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-analysis

Autor: Kanoni, S, Nettleton, J, Hivert, M, Ye, Z, van Rooij, F, Shungin, D, Sonestedt, E, Ngwa, J, Wojczynski, M, Lemaitre, R, Gustafsson, S, Anderson, J, Tanaka, T, Hindy, G, Saylor, G, Renstrom, F, Bennett, A, van Duijn, C, Florez, J, Fox, C, Hofman, A, Hoogeveen, R, Houston, D, Hu, F, Jacques, P, Johansson, I, Lind, L, Liu, Y, McKeown, N, Ordovas, J, Pankow, J, Sijbrands, E, Syvänen, A, Uitterlinden, A, Yannakoulia, M, Zillikens, M, Wareham, N, Prokopenko, I, Bandinelli, S, Forouhi, N, Cupples, L, Loos, R, Hallmans, G, Dupuis, J, Langenberg, C, Ferrucci, L, Kritchevsky, S, McCarthy, M, Ingelsson, E, Borecki, I, Witteman, J, Orho-Melander, M, Siscovick, D, Meigs, J, Franks, P, Dedoussis, G

Publikováno v: Diabetes, 60(9), 2407-2416. American Diabetes Association Inc.

OBJECTIVE-Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for beta-cell function and glucose homeostasis. We tested the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b7bb47ca390a6a352560dac1fbdfd746
https://pure.eur.nl/en/publications/435a0522-e32b-4e0c-a123-eb23f8bdc546