Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Netra Joshi"'
Autor:
Netra, Joshi, Julia, Löffler, Karolina, Szczesna, Tyler, Do, Minh, Vu, Jared, Cobb, Huy, Ngo, John, Nguyen, Vincenzo, Carbone, Deborah, Bergmann, Elizabeth, Shin, Tobias, Hartmann, Damien, Gruson
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM). 61:e13-e16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e9a5420d68a93f4fe86a7649924e50
https://doi.org/10.1515/cclm-2022-0638
https://doi.org/10.1515/cclm-2022-0638
Autor:
Theodore R. Holman, Eng H. Lo, Netra Joshi, Ganesha Rai, Qiangli Zhang, Adam Yasgar, Joo Eun Jung, David J. Maloney, Giovanni Diaz, Anton Simeonov, Victor Kenyon, Yu Liu, Klaus van Leyen, Ajit Jadhav, Lena Schultz, Steve Perry
Publikováno v:
Journal of Medicinal Chemistry
A key challenge facing drug discovery today is variability of the drug target between species, such as with 12/15-lipoxygenase (12/15-LOX), which contributes to ischemic brain injury, but its human and rodent isozymes have different inhibitor specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6871470b28bd1089cd22e8e97f25befc
http://europepmc.org/articles/PMC4033661
http://europepmc.org/articles/PMC4033661
Autor:
David J. Maloney, Anton Simeonov, Adam Yasgar, Giovanni Diaz, Edward H. Kerns, J. Brian Jameson, Diane K. Luci, Michael Holinstat, Theodore R. Holman, David A. Taylor-Fishwick, Kate Markham, Norine Kuhn, Ajit Jadhav, Netra Joshi, Steve Perry, Jennifer Yeung, Lena Schultz, Auric Kantz, Jerry L. Nadler
Publikováno v:
Journal of Medicinal Chemistry. 57:495-506
Human lipoxygenases (LOXs) are a family of iron-containing enzymes which catalyze the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c4fd14e69701df88d10c11b0ace0fb
https://doi.org/10.1021/jm4016476
https://doi.org/10.1021/jm4016476
Autor:
Klaus van Leyen, Eng H. Lo, Anton Pekcec, Joseph L. Witztum, Hulya Karatas, Theodore R. Holman, Rajiv R. Ratan, Stefanie Pallast, N. A. Smirnova, Netra Joshi, Kazim Yigitkanli, Irina G. Gazaryan, Emiri T. Mandeville, Joan Montaner
Publikováno v:
Annals of Neurology. 73:129-135
Targeting newly identified damage pathways in the ischemic brain can help to circumvent the currently severe limitations of acute stroke therapy. Here we show that the activity of 12/15-lipoxygenase was increased in the ischemic mouse brain, and 12/1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53d70ad2b0df8cf0e6fe6382645bca2
https://doi.org/10.1002/ana.23734
https://doi.org/10.1002/ana.23734
Autor:
Michael Holinstat, David A. Taylor-Fishwick, David J. Maloney, J. Brian Jameson, Jerry L. Nadler, William Leister, Michelle Armstrong, Ganesha Rai, Theodore R. Holman, Netra Joshi, James M. Bougie, Ajit Jadhav, Lena Schultz, Steve Perry, Anton Simeonov, Victor Kenyon
Publikováno v:
Journal of Medicinal Chemistry. 54:5485-5497
We report the discovery of novel small molecule inhibitors of platelet type 12-human lipoxygenase, which display nanomolar activity against the purified enzyme, using a quantitative high throughput screen (qHTS) on a library of 153,607 compounds. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ab251943bb740fe0c989bc51cb7ad1
https://doi.org/10.1021/jm2005089
https://doi.org/10.1021/jm2005089
Lipoxygenases, important enzymes in inflammation, can regulate their substrate specificity by allosteric interactions with its own hydroperoxide products. In the current work, addition of both 13-(S) hydroxy-9Z,11E-octadecadienoic acid (13-(S)-HODE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360894b0e2b1779b161f5d14d06cebb8
https://europepmc.org/articles/PMC3866584/
https://europepmc.org/articles/PMC3866584/
Autor:
Kazim Yigitkanli, Anton Pekcec, Stefanie Pallast, Emiri Mandeville, Netra Joshi, Natalya Smirnova, Irina G Gazaryan, Rajiv R Ratan, Joseph L Witztum, Theodore R Holman, Eng H Lo, Klaus Van Leyen
Publikováno v:
Stroke. 43
Background and Purpose - Acute phase stroke treatment options are currently very limited. We have previously demonstrated 12/15-lipoxygenase (12/15-LOX) to initiate an apoptotic cell death cascade, contributing to neuronal cell death, but also vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec94dd92be94c006ab510afc6c3f0fc7
https://doi.org/10.1161/str.43.suppl_1.a3494
https://doi.org/10.1161/str.43.suppl_1.a3494