Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

Autor: Brian T. Maybruck, Nethaji Thiyagarajan, Christine B. Doyle, Steven J. Ackerman, Milica Grozdanovic, K. Ravi Acharya, Li Liu, Mark A. Kwatia

Publikováno v: J Allergy Clin Immunol
Grozdanovic, M, Doyle, C, Lu, L, Maybruck, B, Kwatia, M, Thiyagarajan, N, Acharya, R & Ackerman, S 2020, ' Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis ', Journal of Allergy and Clinical Immunology, vol. 146, no. 2, pp. 377-389.e10 . https://doi.org/10.1016/j.jaci.2020.01.013

BackgroundThe human eosinophil Charcot-Leyden Crystal (CLC) protein is a member of the Galectin superfamily and is also known as Galectin-10 (Gal-10). CLC/Gal-10 forms the distinctive hexagonal bipyramidal crystals considered hallmarks of eosinophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93192b0c44ab86a5c41de169872f87b5
https://doi.org/10.1016/j.jaci.2020.01.013

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

Autor: Andrew Potterton, Derek Ogg, Tom D. Bunney, Harshnira Patani, Camilla S.M. Pang, Christine A. Orengo, Nethaji Thiyagarajan, Margaret A. Knowles, Alexander L. Breeze, Sarah V. Williams, Richard A. Norman, Paul Ashford, Jason Breed, Matilda Katan, Mina Edwards, Gary S. Thomson, Christopher R. Phillips

Publikováno v: Oncotarget

Frequent genetic alterations discovered in FGFRs and evidence implicating some as drivers in diverse tumors has been accompanied by rapid progress in targeting FGFRs for anticancer treatments. Wider assessment of the impact of genetic changes on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3614f52b10fad77a5cc91dde49a0051f

Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A

Autor: Bryan D. Smith, K. Ravi Acharya, Nethaji Thiyagarajan, Ronald T. Raines

Publikováno v: FEBS Journal. 278:541-549

Molecular probes are useful for both studying and controlling the functions of enzymes and other proteins. The most useful probes have high affinity for their target, along with small size and resistance to degradation. Here, we report on new surroga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51bf222d0ddf8ffcca71fdeffc96c168
https://doi.org/10.1111/j.1742-4658.2010.07976.x

Crystal structure of α-1,3-galactosyltransferase (α3GT) in a complex with p-nitrophenyl-β-galactoside (pNPβGal)

Autor: K. Ravi Acharya, Tyrone A. Ferns, Percy Tumbale, Haryati Jamaluddin, Keith Brew, Nethaji Thiyagarajan

Publikováno v: Biochemical and Biophysical Research Communications. 385:601-604

The specificities of glycosyltransferases make them useful for the synthesis of biologically active oligosaccharides, but also restrict their range of products. In substrate engineering, substrate promiscuity is enhanced by attaching removable intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09bdd8ff1b4847747229446e4a44cc08
https://doi.org/10.1016/j.bbrc.2009.05.111

First Crystal Structures of Human Carbonic Anhydrase II in Complex with Dual Aromatase−Steroid Sulfatase Inhibitors

Autor: Y.T. Ho, Nethaji Thiyagarajan, K.R. Acharya, Barry V. L. Potter, Matthew D. Lloyd, Atul Purohit, Oliver B. Sutcliffe, Michael J. Reed, L W L Woo

Publikováno v: Biochemistry. 44:6858-6866

Carbonic anhydrase (CA) catalyzes the reversible hydration of carbon dioxide to hydrogen carbonate. The role of CA in maintaining pH balance has made it an attractive drug target for the treatment of cancer, and it has recently been implicated in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500b55ca5d2ceb92367a1e26b214ba48
https://doi.org/10.1021/bi047692e