Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Neta Uritsky"'
Publikováno v:
Angewandte Chemie. 128:1712-1716
General-base catalysis in serine proteases still poses mechanistic challenges despite decades of research. Whether proton transfer from the catalytic Ser to His and nucleophilic attack on the substrate are concerted or stepwise is still under debate,
Publikováno v:
Journal of chemical theory and computation. 8(11)
Rhomboid proteases are a ubiquitous family of intramembrane serine proteases in prokaryotic and eukaryotic organisms that cleave membrane proteins in their transmembrane region. Their catalytic activity is centered at a His-Ser catalytic dyad. We app
Publikováno v:
Journal of Chemical Information and Modeling. 50:2256-2265
We introduce an enzyme mechanism-based method, EMBM, aimed at rational design of chemical sites, CS, of reaction coordinate analog inhibitors. The energy of valence reorganization of CS, caused by the formation of the enzyme-inhibitor covalent comple
Autor:
Neta Uritsky, Olga Viskind, Hanoch Senderowitz, Shlomo Sasson, Ella Meltzer-Mats, Lily Pasternak, Gali Babai-Shani, Arie Gruzman, Jürgen Eckel, Erol Cerasi, Tamar Getter
Publikováno v:
Journal of medicinal chemistry. 56(13)
Adenosine 5'-monophosphate activated protein kinase (AMPK) has emerged as a major potential target for novel antidiabetic drugs. We studied the structure of 2-chloro-5-((Z)-((E)-5-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-4-oxothiazolidin
In the first catalytic step in serine proteases, the attacking Ser nucleophile forms an unstable covalent anionic tetrahedral complex, TC(O-), with the carbonyl group of the substrate (Fig. 1a).[1] In the case of reaction coordinate analog inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfed83a477e1ef51622a64d38027ed6
https://europepmc.org/articles/PMC3088911/
https://europepmc.org/articles/PMC3088911/
Autor:
Tamar Traube, Subramaniam Vijayakumar, Michal Hirsch, Neta Uritsky, Michael Shokhen, Amnon Albeck
Publikováno v:
Journal of Chemical Information & Modeling; Dec2010, Vol. 50 Issue 12, p2256-2265, 10p