Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nestoras, Karathanasis"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1011550 (2024)
Prioritization or ranking of different cell types in a single-cell RNA sequencing (scRNA-seq) framework can be performed in a variety of ways, some of these include: i) obtaining an indication of the proportion of cell types between the different con
Externí odkaz:
https://doaj.org/article/87441d67f9d448bf965ef6b45427b5d8
Autor:
Aitana Neves, Isabel Cuesta, Erik Hjerde, Terje Klemetsen, David Salgado, Jacques van Helden, Nadim Rahman, Nazeefa Fatima, Nestoras Karathanasis, Pawel Zmora, Wolmar Nyberg Åkerström, Sushma Nagaraja Grellscheid, Zahra Waheed, Niklas Blomberg
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
The COVID-19 pandemic has exemplified the importance of interoperable and equitable data sharing for global surveillance and to support research. While many challenges could be overcome, at least in some countries, many hurdles within the organizatio
Externí odkaz:
https://doaj.org/article/d1e899771f6c4e9c99f8298eee7cfd8c
Autor:
Nestoras Karathanasis, Daniel Hwang, Vibol Heng, Rimal Abhimannyu, Phillip Slogoff-Sevilla, Gina Buchel, Victoria Frisbie, Peiyao Li, Dafni Kryoneriti, Isidore Rigoutsos
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010615 (2022)
The "replication crisis" is a methodological problem in which many scientific research findings have been difficult or impossible to replicate. Because the reproducibility of empirical results is an essential aspect of the scientific method, such fai
Externí odkaz:
https://doaj.org/article/40248b4e44854a57ad5531c5516e8273
Autor:
Ewoud Ewing, Lara Kular, Sunjay J. Fernandes, Nestoras Karathanasis, Vincenzo Lagani, Sabrina Ruhrmann, Ioannis Tsamardinos, Jesper Tegner, Fredrik Piehl, David Gomez-Cabrero, Maja Jagodic
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 411-423 (2019)
Background: Multiple Sclerosis (MS) is a chronic inflammatory disease and a leading cause of progressive neurological disability among young adults. DNA methylation, which intersects genes and environment to control cellular functions on a molecular
Externí odkaz:
https://doaj.org/article/5155ed9ade0b48e3b8312ae06be2f0d6
Autor:
Nuria Planell, Vincenzo Lagani, Patricia Sebastian-Leon, Frans van der Kloet, Ewoud Ewing, Nestoras Karathanasis, Arantxa Urdangarin, Imanol Arozarena, Maja Jagodic, Ioannis Tsamardinos, Sonia Tarazona, Ana Conesa, Jesper Tegner, David Gomez-Cabrero
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Technologies for profiling samples using different omics platforms have been at the forefront since the human genome project. Large-scale multi-omics data hold the promise of deciphering different regulatory layers. Yet, while there is a myriad of bi
Externí odkaz:
https://doaj.org/article/99f7643058d144149055b509b7075821
Autor:
Phillipe Loher, Nestoras Karathanasis
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
The development of single-cell sequencing technologies has allowed researchers to gain important new knowledge about the expression profile of genes in thousands of individual cells of a model organism or tissue. A common disadvantage of this technol
Externí odkaz:
https://doaj.org/article/b1abdf6e112f4665abef6044217524e1
Autor:
Nestoras Karathanasis, Eric Londin, Isidore Rigoutsos, Venetia Pliatsika, Paul F. Bray, Phillipe Loher, Aristeidis G. Telonis
Publikováno v:
Bioinformatics
Motivation MicroRNA (miRNA) precursor arms give rise to multiple isoforms simultaneously called ‘isomiRs.’ IsomiRs from the same arm typically differ by a few nucleotides at either their 5′ or 3′ termini or both. In humans, the identities and
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165545 (2016)
The advance of omics technologies has made possible to measure several data modalities on a system of interest. In this work, we illustrate how the Non-Parametric Combination methodology, namely NPC, can be used for simultaneously assessing the assoc
Externí odkaz:
https://doaj.org/article/51a5b702762f48cfb0fce53959f71139
Autor:
Nestoras Karathanasis
MicroRNAs belong to the large family of small non coding RNAs. They regulateprotein synthesis by binding to their mRNA targets causing mRNA degradationor translational repression. A large number of miRNAs have been associated withcancer because they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47ef5305d50396f5060e763b33747a20
https://doi.org/10.12681/eadd/39489
https://doi.org/10.12681/eadd/39489
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126151 (2015)
We address the problem of predicting the position of a miRNA duplex on a microRNA hairpin via the development and application of a novel SVM-based methodology. Our method combines a unique problem representation and an unbiased optimization protocol
Externí odkaz:
https://doaj.org/article/3e195377f5864135bf25e67cc7486ee8