Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nestor Mas Gomez"'
Autor:
Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya, Prema Velusamy, Matthew Sayre, Alvaro Garcia, Nestor Mas Gomez, Dianne Langford
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-16 (2020)
Abstract Background Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain metabolism. Among neurodegenerative disorders, people living with human immunodeficiency virus (HIV) and Alzheimer’s diseas
Externí odkaz:
https://doaj.org/article/99de0527c9a34e6fb3e56d5a445214bf
Autor:
Puttipong Sripinun, Wennan Lu, Sophia P. Clark, Aurora Cenaj, Farraj Albalawi, Assraa Hassan Jassim, Claire H. Mitchell, Nestor Mas Gomez, Huen-Yee Tso, Keith E. Campagno
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Background The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0acf9e3c6f3774a9db9abc5bf079f62
http://europepmc.org/articles/PMC8454080
http://europepmc.org/articles/PMC8454080
Autor:
Yi-Ping Li, Shuting Yang, Ziqing Li, Merry Jo Oursler, Alyssa Gilmore, Claire H. Mitchell, Shuying Yang, Tongjun Liu, Chuanyun Fu, Nestor Mas Gomez, Jormay Lim
Publikováno v:
Journal of Bone and Mineral Research. 34:752-764
Bone homeostasis intimately relies on the balance between osteoblasts (OBs) and osteoclasts (OCs). Our previous studies have revealed that regulator of G protein signaling protein 12 (Rgs12), the largest protein in the Rgs super family, is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56af66a05eee4fcb2ae0395672c3fa0
https://doi.org/10.1002/jbmr.3645
https://doi.org/10.1002/jbmr.3645
Autor:
Aurora Cenaj, Wennan Lu, Huen-Yee Tso, Keith E. Campagno, Claire H. Mitchell, Sripinun Puttipong, Sophia P. Clark, Farraj Albalawi, Assraa Hassan Jassim, Nestor Mas Gomez
Background: The endogenous signals leading to microglial activation represent central components of neuroinflammatory cascades. Given ATP release accompanies mechanical strain to neural tissue, and the P2X7R for ATP is expressed on microglial cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ccfea9c231840d693904e16afc97fd
https://doi.org/10.21203/rs.3.rs-424697/v1
https://doi.org/10.21203/rs.3.rs-424697/v1
Autor:
Dianne Langford, Prema Velusamy, Santhanam Shanmughapriya, Alvaro Garcia, Matthew Sayre, Nestor Mas Gomez, Kalimuthusamy Natarajaseenivasan
Publikováno v:
Translational Neurodegeneration
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-16 (2020)
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-16 (2020)
Background Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain metabolism. Among neurodegenerative disorders, people living with human immunodeficiency virus (HIV) and Alzheimer’s disease (AD) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bd3519f16593c9d68618d520f7ce15
http://europepmc.org/articles/PMC7397656
http://europepmc.org/articles/PMC7397656
Autor:
Edward T. Lally, Anuradha Dhingra, Alexander Giannakakis, Nestor Mas Gomez, Kathleen Boesze-Battaglia, Roland Benz, Syed A Fahim, Nataliya Balashova, Claire H. Mitchell, Jinery Lora
Publikováno v:
Pathogens, Vol 9, Iss 2, p 74 (2020)
Pathogens
Volume 9
Issue 2
Pathogens
Volume 9
Issue 2
Leukotoxin (LtxA), from oral pathogen Aggregatibacter actinomycetemcomitans, is a secreted membrane-damaging protein. LtxA is internalized by &beta
2 integrin LFA-1 (CD11a/CD18)-expressing leukocytes and ultimately causes cell death
however
2 integrin LFA-1 (CD11a/CD18)-expressing leukocytes and ultimately causes cell death
however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb81a2040d907ce0c3edfe454d42d2af
https://www.mdpi.com/2076-0817/9/2/74
https://www.mdpi.com/2076-0817/9/2/74
Autor:
Sriganesh Ramachandra Rao, Claire H. Mitchell, Janet R. Sparrow, Nestor Mas Gomez, Ueda Keiko, Bruce A. Pfeffer, Lara A. Skelton, Aryn M. Rowsam, Steven J. Fliesler
Publikováno v:
Autophagy. 14:1796-1817
Treatment of rats with the cholesterol pathway inhibitor AY9944 produces an animal model of Smith-Lemli-Opitz syndrome (SLOS), an autosomal recessive disease caused by defective cholesterol synthesis. This SLOS rat model undergoes progressive and irr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9810111a2246a1e00ad3ca456ea64ad5
https://doi.org/10.1080/15548627.2018.1490851
https://doi.org/10.1080/15548627.2018.1490851
Autor:
Keith E. Campagno, Kirill Kiselyov, Claire H. Mitchell, Susan A. Slaugenhaupt, Jason C. Lim, Steven J. Fliesler, Wennan Lu, Yulia Grishchuk, Bruce A. Pfeffer, Nestor Mas Gomez
Publikováno v:
The FASEB Journal. 32:782-794
The transient receptor potential cation channel mucolipin 1 (TRPML1) channel is a conduit for lysosomal calcium efflux, and channel activity may be affected by lysosomal contents. The lysosomes of retinal pigmented epithelial (RPE) cells are particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ca6e2020616ead2bafb398f71dbe3a
https://doi.org/10.1096/fj.201700220rr
https://doi.org/10.1096/fj.201700220rr
Autor:
Edward T. Lally, Nataliya Balashova, Syed A Fahim, Kathleen Boesze-Battaglia, Anuradha Dhingra, Nestor Mas Gomez, Roland Benz, Alexander Giannakakis, Claire H. Mitchell
Leukotoxin (LtxA) from oral pathogenAggregatibacter actinomycetemcomitansis a secreted membrane-damaging protein. LtxA is internalized by β2 integrin LFA-1 (CD11a/CD18) expressing leukocytes and ultimately causes cell death; however toxin localizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b04be12d09726c8d3e33bcd45083bc7
Autor:
Keith E. Campagno, Puttipong Sripinun, Lily P. See, Jiaqi Li, Wennan Lu, Assraa Hassan Jassim, Néstor Más Gómez, Claire H. Mitchell
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8784 (2024)
This study asked whether the P2X7 receptor was necessary and sufficient to trigger astrocyte polarization into neuroinflammatory activation states. Intravitreal injection of agonist BzATP increased gene expression of pan-astrocyte activation markers
Externí odkaz:
https://doaj.org/article/d87353b3622f4c7096287b0345388166