Proteogenomic insights suggest druggable pathways in endometrial carcinoma.

Autor: Dou Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Katsnelson L; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Gritsenko MA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Hu Y; Department of Pathology and Oncology, Johns Hopkins University, Baltimore, MD 21231, USA., Reva B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hong R; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Wang YT; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Kolodziejczak I; International Institute for Molecular Oncology, 20-203 Poznań, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland., Lu RJ; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA., Tsai CF; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Bu W; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Liu W; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Guo X; Division of Gynecologic Oncology, University of South Florida Morsani College of Medicine and Tampa General Hospital Cancer Institute, Tampa, FL 33606, USA., An E; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Arend RC; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL 35249, USA., Bavarva J; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Chen L; Department of Pathology and Oncology, Johns Hopkins University, Baltimore, MD 21231, USA., Chu RK; Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Czekański A; Wroclaw Medical University and Lower Silesian Oncology, Pulmonology and Hematology Center (DCOPIH), Wrocław, Poland., Davoli T; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Demicco EG; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1X5, Canada., DeLair D; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., Devereaux K; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., Dhanasekaran SM; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Dottino P; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Dover B; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL 35249, USA., Fillmore TL; Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Foxall M; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL 35249, USA., Hermann CE; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, NYU Grossman School of Medicine, New York, NY 10016, USA., Hiltke T; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Hostetter G; Van Andel Research Institute, Grand Rapids, MI 49503, USA., Jędryka M; Wroclaw Medical University and Lower Silesian Oncology, Pulmonology and Hematology Center (DCOPIH), Wrocław, Poland., Jewell SD; Van Andel Research Institute, Grand Rapids, MI 49503, USA., Johnson I; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Kahn AG; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA., Ku AT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA., Kumar-Sinha C; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Kurzawa P; Heliodor Swiecicki Clinical Hospital in Poznan ul. Przybyszewskiego 49, 60-355 Poznań, Poland; Poznań University of Medical Sciences, 61-701 Poznań, Poland., Lazar AJ; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lazcano R; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lei JT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Li Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Liao Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Lih TM; Department of Pathology and Oncology, Johns Hopkins University, Baltimore, MD 21231, USA., Lin TT; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Martignetti JA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Masand RP; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Matkowski R; Wroclaw Medical University and Lower Silesian Oncology, Pulmonology and Hematology Center (DCOPIH), Wrocław, Poland., McKerrow W; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Mesri M; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Monroe ME; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Moon J; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Moore RJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Nestor MD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Newton C; Van Andel Research Institute, Grand Rapids, MI 49503, USA., Omelchenko T; The Rockefeller University, New York, NY 10065, USA., Omenn GS; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Payne SH; Department of Biology, Brigham Young University, Provo, UT 84602, USA., Petyuk VA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Robles AI; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Rodriguez H; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Ruggles KV; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Division of Precision Medicine, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Rykunov D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Savage SR; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Schepmoes AA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Shi T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Shi Z; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Tan J; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Taylor M; Department of Biology, Brigham Young University, Provo, UT 84602, USA., Thiagarajan M; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Wang JM; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Weitz KK; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Wen B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Williams CM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Wu Y; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA., Wyczalkowski MA; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA., Yi X; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Zhang X; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA., Zhao R; Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Mutch D; Washington University School of Medicine, Saint Louis, MO 63110, USA., Chinnaiyan AM; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Nesvizhskii AI; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Wang P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Wiznerowicz M; International Institute for Molecular Oncology, 60-203 Poznań, Poland; Heliodor Swiecicki Clinical Hospital in Poznan ul. Przybyszewskiego 49, 60-355 Poznań, Poland; Poznań University of Medical Sciences, 61-701 Poznań, Poland., Ding L; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA., Mani DR; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Zhang H; Department of Pathology and Oncology, Johns Hopkins University, Baltimore, MD 21231, USA., Anderson ML; Division of Gynecologic Oncology, University of South Florida Morsani College of Medicine and Tampa General Hospital Cancer Institute, Tampa, FL 33606, USA. Electronic address: mlander5@usf.edu., Rodland KD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97221, USA. Electronic address: rodland@ohsu.edu., Zhang B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: bing.zhang@bcm.edu., Liu T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA. Electronic address: tao.liu@pnnl.gov., Fenyö D; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: david@fenyolab.org.

Publikováno v: Cancer cell [Cancer Cell] 2023 Sep 11; Vol. 41 (9), pp. 1586-1605.e15. Date of Electronic Publication: 2023 Aug 10.