Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Nesrine, Rahmouni"'
Autor:
Peter Kunach, Jaime Vaquer-Alicea, Matthew S. Smith, Jim Monistrol, Robert Hopewell, Luc Moquin, Joseph Therriault, Cecile Tissot, Nesrine Rahmouni, Gassan Massarweh, Jean-Paul Soucy, Marie-Christine Guiot, Brian K. Shoichet, Pedro Rosa-Neto, Marc I. Diamond, Sarah H. Shahmoradian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Positron Emission Tomography (PET) ligands have advanced Alzheimer’s disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identify AD brain tissue with elevated tau burden, purify filaments, and determine the structu
Externí odkaz:
https://doaj.org/article/5efd6927183340d0a34822a15bd6da61
Autor:
Yi-Ting Wang, Joseph Therriault, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S. Mathotaarachchi, Jenna Stevenson, Firoza Z. Lussier, Andréa L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Females represent approximately 70% of the Alzheimer’s disease (AD) cases and the literature has proposed a connection between the decreased estrogen levels during menopause and an increased AD risk. Previous investigations have
Externí odkaz:
https://doaj.org/article/daf9534a01764ab599de980ae7f154aa
Autor:
Julie Ottoy, Min Su Kang, Jazlynn Xiu Min Tan, Lyndon Boone, Reinder Vos de Wael, Bo-yong Park, Gleb Bezgin, Firoza Z. Lussier, Tharick A. Pascoal, Nesrine Rahmouni, Jenna Stevenson, Jaime Fernandez Arias, Joseph Therriault, Seok-Jun Hong, Bojana Stefanovic, JoAnne McLaurin, Jean-Paul Soucy, Serge Gauthier, Boris C. Bernhardt, Sandra E. Black, Pedro Rosa-Neto, Maged Goubran
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Alzheimer’s disease (AD) is a brain network disorder where pathological proteins accumulate through networks and drive cognitive decline. Yet, the role of network connectivity in facilitating this accumulation remains unclear. Using in-viv
Externí odkaz:
https://doaj.org/article/fde529232e944d638ac5830511c20cef
Autor:
Marcel S. Woo, Joseph Therriault, Erin M. Jonaitis, Rachael Wilson, Rebecca E. Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J. Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J. Betthauser, Firoza Z. Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C. Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Jesse Klostranec, Paolo Vilali, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C. Johnson, Pedro Rosa-Neto
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105413- (2024)
Summary: Background: Blood-based disease staging across the Alzheimer's disease (AD) continuum holds the promise to identify individuals that profit from disease-modifying therapies. We set out to identify Braak V+ (Braak V and/or VI) tau PET-positiv
Externí odkaz:
https://doaj.org/article/fb10423af32b4438978a55cda015eda3
Autor:
Yi-Ting Wang, Nicholas J. Ashton, Stijn Servaes, Johanna Nilsson, Marcel S. Woo, Tharick A. Pascoal, Cécile Tissot, Nesrine Rahmouni, Joseph Therriault, Firoza Lussier, Mira Chamoun, Serge Gauthier, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Andréa L. Benedet
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/892a82c42fb84ac6a6a98d8ee15c62b9
Autor:
Lazaro M. Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K. Karikari, Nicholas J. Ashton, Andréa L. Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C. Kolb, Pedro Rosa-Neto, Yasser Iturria-Medina
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Neuronal dysfunction and cognitive deterioration in Alzheimer’s disease (AD) are likely caused by multiple pathophysiological factors. However, mechanistic evidence in humans remains scarce, requiring improved non-invasive techniques and i
Externí odkaz:
https://doaj.org/article/d1d394702b194a57a434755661c25a8f
Autor:
Wagner S. Brum, Nicholas C. Cullen, Joseph Therriault, Shorena Janelidze, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Andrea L. Benedet, Eduardo R. Zimmer, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Giovanni B. Frisoni, Nicholas J. Ashton, Kaj Blennow, Niklas Mattsson-Carlgren, Pedro Rosa-Neto, Oskar Hansson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Blood-based biomarkers for screening may guide tau positrion emissition tomography (PET) scan referrals to optimize prognostic evaluation in Alzheimer’s disease. Plasma Aβ42/Aβ40, pTau181, pTau217, pTau231, NfL, and GFAP were measured al
Externí odkaz:
https://doaj.org/article/45431c464f6049b581c84b0d07def687
Autor:
Lazaro M. Sanchez-Rodriguez, Ahmed F. Khan, Quadri Adewale, Gleb Bezgin, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Hongxiu Jiang, Xiaoqian Chai, Felix Carbonell, Pedro Rosa-Neto, Yasser Iturria-Medina
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The molecular mechanisms underlying neuronal dysfunction in Alzheimer’s disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ)
Externí odkaz:
https://doaj.org/article/1657c77c5c334d1eb95796dc2572b831
Autor:
Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantif
Externí odkaz:
https://doaj.org/article/b47ea600285b4aea8f46ab3e27b0c3b2
Autor:
Joseph Therriault, Nicholas James Ashton, Ilaria Pola, Gallen Triana-Baltzer, Wagner Scheeren Brum, Guglielmo Di Molfetta, Burak Arslan, Nesrine Rahmouni, Cecile Tissot, Stijn Servaes, Jenna Stevenson, Arthur Cassa Macedo, Tharick Ali Pascoal, Hartmuth Christian Kolb, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea Lessa Benedet
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105046- (2024)
Summary: Background: Blood-based biomarkers of Alzheimer’s disease (AD) have become increasingly important as scalable tools for diagnosis and determining clinical trial eligibility. P-tau217 is the most promising due to its excellent sensitivity a
Externí odkaz:
https://doaj.org/article/fff9d8f2702248738ad2be007babdcd7