Lithium can mildly increase health during ageing but not lifespan in mice.

Autor: Nespital, Tobias¹ (AUTHOR), Neuhaus, Brit¹ (AUTHOR), Mesaros, Andrea¹ (AUTHOR), Pahl, André¹ (AUTHOR), Partridge, Linda^1,2 (AUTHOR) partridge@age.mpg.de

Publikováno v: Aging Cell. Oct2021, Vol. 20 Issue 10, p1-6. 6p.

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Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

Autor: Bolukbasi, Ekin, Khericha, Mobina, Regan, Jennifer C., Ivanov, Dobril K., Adcott, Jennifer, Dyson, Miranda C., Nespital, Tobias, Thornton, Janet M., Alic, Nazif, Partridge, Linda

Publikováno v: Cell Reports
Bolukbasi, E, Khericha, M, Regan, J, Ivanov, D, Adcott, J, Dyson, M C, Nespital, T, Thornton, J M, Alic, N & Partridge, L 2017, ' Intestinal fork head regulates nutrient absorption and promotes longevity ', Cell Reports, vol. 21, no. 3, pp. 641-653 . https://doi.org/10.1016/j.celrep.2017.09.042
Cell Reports, Vol 21, Iss 3, Pp 641-653 (2017)
Cell Rep

Summary Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::30cabd7bca99cce0e6455de67da282e9
http://europepmc.org/articles/PMC5656751

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

Autor: Castillo-Quan, Jorge Ivan, Li, Li, Kinghorn, Kerri J., Ivanov, Dobril K., Tain, Luke S., Slack, Cathy, Kerr, Fiona, Nespital, Tobias, Thornton, Janet, Hardy, John, Bjedov, Ivana, Partridge, Linda

Publikováno v: Cell Reports
Cell Rep
Cell Reports, Vol 15, Iss 3, Pp 638-650 (2016)

Summary The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b0443d2ba860f52a87d98bd7b0668281