Výsledky vyhledávání - "Nesbitt D. Brown"

Supplemental putrescine reverses ethanol-associated inhibition of liver regeneration

Autor: Nesbitt D. Brown, Anna Mae Diehl, Suzan Abdo

Publikováno v: Hepatology. 12:633-637

Biosynthesis of the polyamines, putrescine, spermidine and spermine, is required for DNA synthesis and liver regeneration after partial hepatectomy. Chronic ethanol consumption impairs polyamine synthesis during the prereplicative phase after partial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7e83d34a385357957f8fe81f2fa3b1
https://doi.org/10.1002/hep.1840120402

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Stabilization of thymopentin and preservation of its pharmacological properties by 2-hydroxypropyl-beta-cyclodextrin

Autor: Nesbitt D. Brown, Dennis L. Butler, Peter K. Chiang

Publikováno v: The Journal of pharmacy and pharmacology. 45(7)

Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-β-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 × 10−6 m) after fourteen months of storage at room temperature. Thus, in contrast to the ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741df5051150f5f78b52058562f97d62
https://pubmed.ncbi.nlm.nih.gov/8105066

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Synthesis and antimuscarinic activity of 2-[N-(ethyl)-(N-beta-hydroxyethyl)]aminoethyl 2,2-diphenylpropionate, a metabolite of aprophen

Autor: Lawrence R. Phillips, Ruthann M. Smejkal, Haim Leader, Peter K. Chiang, Richard K. Gordon, Nesbitt D. Brown

Publikováno v: Journal of pharmaceutical sciences. 82(6)

The preparation of 2-[N-(ethyl)-(N-beta-hydroxyethyl)]amino-ethyl 2,2-diphenylpropionate (1), a metabolite of aprophen [2-diethylaminoethyl 2,2-diphenylpropionate], is described. Hydrolysis of [2-(2-chloroethyl)ethylamino]ethyl acetate hydrochloride

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ca4dea29f6bee3d8b086ccb5043e6e
https://pubmed.ncbi.nlm.nih.gov/8331525

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Ethanol-associated alterations in the kinetics of putrescine uptake and metabolism by the regenerating liver

Autor: Anna Mae Diehl, Jeffrey S. Smith, Shi Qi Yang, Robert A. Casero, David Raiford, Richard K. Gordon, Nesbitt D. Brown

Publikováno v: Alcoholism, clinical and experimental research. 16(1)

Biosynthesis of the polyamines, putrescine, spermidine, and spermine is required for DNA synthesis and liver regeneration after partial hepatectomy. We have previously reported that chronic ethanol consumption impairs polyamine synthesis and signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27d05aa811d6347067e9ac2119b5cad
https://pubmed.ncbi.nlm.nih.gov/1558302

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Postganglionic Nicotinic Action of Anatoxin-A On Guinea Pig Ileum Antagonized By Thymopentin

Autor: Nesbitt D. Brown, Richard K. Gordon, Bhupendra P. Doctor, J. Katzhendler, Peter K. Chiang

Publikováno v: Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle ISBN: 9781461364832

Anatoxin-a (ANTX) is a bicyclic amine exotoxin produced by the blue green algae Anabaena flos-aquae, and has been found to cause death to livestock and waterfowl via a blockade of neuromuscular transmission and subsequent respiratory paralysis (1, 2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bea626e47f41b60a40cf1120a910463
https://doi.org/10.1007/978-1-4615-3362-7_66

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Isolation and identification of beta-hydroxyethylaprophen: a urinary metabolite of aprophen in rats

Autor: Peter K. Chiang, Haim Leader, Lawrence R. Phillips, Nesbitt D. Brown

Publikováno v: Journal of chromatography. 563(2)

The metabolism of the anticholinergic drug aprophen was studied in rats after oral administration via stomach intubation. β-Hydroxyethylaprophen, a major urinary metabolite of aprophen, was isolated and identified by normal-phase high-performance li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b2233b87a1d0e24f7a80de35e4e841
https://pubmed.ncbi.nlm.nih.gov/2056011

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Effect of ethanol on polyamine synthesis during liver regeneration in rats

Autor: Anna Mae Diehl, Michael R. Wells, Snorri S. Thorgeirsson, Clifford J. Steer, Nesbitt D. Brown

Publikováno v: The Journal of clinical investigation. 85(2)

Ethanol consumption retards the hepatic regenerative response to injury. This may contribute to the pathogenesis of liver injury in alcoholic individuals. The mechanisms responsible for ethanol-associated inhibition of liver regeneration are poorly u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b29d7e4b3996b4da78024897071434d
https://pubmed.ncbi.nlm.nih.gov/2298913

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