The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits

Autor: Nadia Rosenberg, Jean-Yves Chatton, Céline Schmuziger, Haissa de Castro Abrantes, Julien Puyal, Leonardo Restivo, Stefan Offermanns, Anne-Bérengère Rocher, Marc Briquet

Publikováno v: The Journal of neuroscience, vol. 39, no. 23, pp. 4422-4433

The discovery of a G-protein-coupled receptor for lactate named hydroxycarboxylic acid receptor 1 (HCAR1) in neurons has pointed to additional nonmetabolic effects of lactate for regulating neuronal network activity. In this study, we characterized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1ddc0faab920f78a8b98536bd98952
https://serval.unil.ch/resource/serval:BIB_A7DD5C903273.P001/REF.pdf

Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity

Autor: Maxime G. Blanchard, Stephan Kellenberger

Publikováno v: Pflügers Archiv
Pflügers Archiv, vol. 461, no. 1, pp. 123-139

Acid-sensing ion channels (ASICs) are neuronal H+-gated cation channels, and the transient receptor potential vanilloid 1 channel (TRPV1) is a multimodal cation channel activated by low pH, noxious heat, capsaicin, and voltage. ASICs and TRPV1 are bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdddd167662cd1cd1c0487071ce7d027
https://my.unil.ch/serval/document/BIB_9767C2FF9F17.pdf

The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons

Autor: Ryan J. Watts, Jennifer M. MacDonald, Amy E. Sheehan, Marc R. Freeman, Margaret G. Beach, Ermelinda Porpiglia

Publikováno v: MacDonald, J M, Beach, M G, Porpiglia, E, Sheehan, A E, Watts, R J & Freeman, M R 2006, ' The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons ', Neuron, vol. 50, no. 6, pp. 869-81 . https://doi.org/10.1016/j.neuron.2006.04.028

Neuron-glia communication is central to all nervous system responses to trauma, yet neural injury signaling pathways remain poorly understood. Here we explore cellular and molecular aspects of neural injury signaling in Drosophila. We show that trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622427d85061baba0b778bd23013fc93

The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping

Autor: Debiao Zhao, Stephen Pathirana, Mary Bownes

Publikováno v: Pathirana, S, Zhao, D & Bownes, M 2001, ' The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping ', Mechanisms of Development, vol. 109, no. 2, pp. 137-50 . https://doi.org/10.1016/S0925-4773(01)00557-3

The loco gene encodes members of a family of RGS proteins responsible for the negative regulation of G-protein signalling. At least two transcripts of loco are expressed in oogenesis, loco-c2 is observed in the anterior-dorsal follicle cells and is d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e427aa120e138c5c9f9e80280ba5d85
https://doi.org/10.1016/s0925-4773(01)00557-3

Targeting pannexin1 improves seizure outcome

Autor: Anne Charollais, Dorothée Caille, Naman K. Patel, Paolo Meda, Eliana Scemes, Marcelo F. Santiago, Sarah E. Lutz, Jana Velíšková

Publikováno v: PLOS ONE, Vol. 6, No 9 (2011) P. e25178
PLoS ONE
PLoS ONE, Vol 6, Iss 9, p e25178 (2011)
PloS one
PLoS ONE; Vol 6

Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter GABA is one of several causes of seizures. ATP has also been implicated in epilepsy. However, little is known about the mechanisms involved in the release o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1d9067a0c401fd204e0ac3a5c9ca63
https://archive-ouverte.unige.ch/unige:24824